Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Laura Jimbu"'
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 121 (2024)
MicroRNAs (miRNAs) are short, non-coding ribonucleic acids (RNAs) associated with gene expression regulation. Since the discovery of the first miRNA in 1993, thousands of miRNAs have been studied and they have been associated not only with physiologi
Externí odkaz:
https://doaj.org/article/75fe2685e4ae45fc8671797b993fe463
Autor:
Alexandra Neaga, Cristina Bagacean, Adrian Tempescul, Laura Jimbu, Oana Mesaros, Cristina Blag, Ciprian Tomuleasa, Corina Bocsan, Mihaela Gaman, Mihnea Zdrenghea
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Acute myeloid leukemia (AML) is an aggressive myeloid malignancy with poor outcomes despite very intensive therapeutic approaches. For the majority of patients which are unfit and treated less intensively, the prognosis is even worse. There has been
Externí odkaz:
https://doaj.org/article/b0e9cdf50e144470bb9730ce10192e86
Autor:
Claudia Banescu, Florin Tripon, Anca S. Bojan, Adrian P. Trifa, Carmen Muntean, George Andrei Crauciuc, Alina Boglis, Marcela Candea, Erzsebet Lazar, Laura Jimbu, Mihaela Iancu
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 3, p 409 (2022)
Toll-like receptors (TLRs) have an important role in innate immunity, and single nucleotide polymorphisms (SNPs) of TLR genes influence the risk of developing hematological malignancies. We aimed to evaluate the effect of TLR2 (rs5743708), TLR4 (rs11
Externí odkaz:
https://doaj.org/article/975392ff2d4a4382a77028b096a34c51
Autor:
Laura Jimbu, Oana Mesaros, Alexandra Neaga, Ana Maria Nanut, Ciprian Tomuleasa, Delia Dima, Corina Bocsan, Mihnea Zdrenghea
Publikováno v:
Pharmaceuticals, Vol 14, Iss 11, p 1105 (2021)
Tumor cells promote the suppression of host anti-tumor type 1 T cell responses by various mechanisms, including the upregulation of surface inhibitory molecules such as programmed death ligand (PD-L)-1, and the production of immunosuppressive cytokin
Externí odkaz:
https://doaj.org/article/30fd7aa677ee4ac38f6d8cd9ed008ba7
Autor:
Alexandra Neaga, Laura Jimbu, Oana Mesaros, Madalina Bota, Diana Lazar, Simona Cainap, Cristina Blag, Mihnea Zdrenghea
Publikováno v:
Cancers, Vol 13, Iss 15, p 3886 (2021)
It is a new and exciting time for acute lymphoblastic leukemia (ALL). While nearly 50 years ago, only one in nine children with ALL survived with chemotherapy, nowadays nearly 90% of children have a chance of long-term survival. Adults with ALL, as w
Externí odkaz:
https://doaj.org/article/52e0c45925014b099d217ef2fef29be0
Autor:
Laura Jimbu, Oana Mesaros, Cristian Popescu, Alexandra Neaga, Iulia Berceanu, Delia Dima, Mihaela Gaman, Mihnea Zdrenghea
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 288 (2021)
Checkpoint inhibitors were a major breakthrough in the field of oncology. In September 2014, based on the KEYNOTE-001 study, the Food and Drug Administration (FDA) approved pembrolizumab, a programmed cell death protein 1 (PD-1) inhibitor, for advanc
Externí odkaz:
https://doaj.org/article/cf5a7b9e25d74c549f0e51647a4e2050
Autor:
Oana Mesaros, Laura Jimbu, Alexandra Neaga, Cristian Popescu, Iulia Berceanu, Ciprian Tomuleasa, Bogdan Fetica, Mihnea Zdrenghea
Publikováno v:
Biomedicines, Vol 8, Iss 11, p 516 (2020)
Macrophages are terminally differentiated innate immune cells. Through their activation, they can be polarized towards the pro-inflammatory M1 type or the wound healing-associated, anti-inflammatory M2 type macrophages. In the tumor microenvironment
Externí odkaz:
https://doaj.org/article/b68edf339dd943d5bf673ed0841dfa5a
Autor:
Florin Tripon, Mihaela Iancu, Adrian Trifa, George Andrei Crauciuc, Alina Boglis, Beata Balla, Adriana Cosma, Delia Dima, Marcela Candea, Erzsebet Lazar, Laura Jimbu, Claudia Banescu
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 6, p 1672 (2020)
This study aimed to explore the associations between the TP53 rs1042522 (TP53 Arg72Pro), MDM2 rs2279744 (MDM2 309T>G), rs3730485 (MDM2 del1518), MDM4 rs4245739 (MDM4 34091 C>A) variants and odds of developing acute myeloid leukemia (AML) in a cohort
Externí odkaz:
https://doaj.org/article/20251366b6264963b7418cbeca2f4a68
Are Community Acquired Respiratory Viral Infections an Underestimated Burden in Hematology Patients?
Autor:
Cristian-Marian Popescu, Aurora Livia Ursache, Gavriela Feketea, Corina Bocsan, Laura Jimbu, Oana Mesaros, Michael Edwards, Hongwei Wang, Iulia Berceanu, Alexandra Neaga, Mihnea Zdrenghea
Publikováno v:
Microorganisms, Vol 7, Iss 11, p 521 (2019)
Despite a plethora of studies demonstrating significant morbidity and mortality due to community-acquired respiratory viral (CRV) infections in intensively treated hematology patients, and despite the availability of evidence-based guidelines for the
Externí odkaz:
https://doaj.org/article/af8e1e8ef880448d84a191dde900cd7c
Autor:
Mihnea Zdrenghea, Alexandra Neaga, Simona Cainap, Madalina Bota, Laura Jimbu, Oana Mesaros, Diana Lazar, Cristina Blag
Publikováno v:
Cancers
Cancers, Vol 13, Iss 3886, p 3886 (2021)
Cancers, Vol 13, Iss 3886, p 3886 (2021)
Simple Summary Around 90% of children diagnosed with acute lymphoblastic leukemia are long-term survivors due to the efforts made in the last decades to tailor the chemotherapy protocols, which is not the case for the adult population. This literatur