Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Laura Jeffrey"'
Autor:
Michael Doumit, Roxanne Strachan, Raynuka Lazarus, Peter Middleton, Ruth Dentice, Jessica Marouvo, Laura Jeffrey, Hiran Selvadurai, Sheila Sivam, Verity Pacey, Adam Jaffe, Kelly Gray
Publikováno v:
Health Services Insights, Vol 16 (2023)
Background: Standard of care recommend that patients with cystic fibrosis (CF) require screening investigations to assess for complications. Changing models of care due to the COVID19 pandemic may have impacted completion of recommended screening. Ob
Externí odkaz:
https://doaj.org/article/6e8d6593b3704b7bb8b0e49f37bd53a9
Publikováno v:
Enzyme and Microbial Technology. 78:74-83
Thermostability has been considered as a requirement in the starch processing industry to maintain high catalytic activity of pullulanase under high temperatures. Four data driven rational design methods (B-FITTER, proline theory, PoPMuSiC-2.1, and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c045eb294cba4fed074738fc48a0ecc8
https://doi.org/10.1016/j.enzmictec.2015.06.013
https://doi.org/10.1016/j.enzmictec.2015.06.013
Autor:
Feng Peng, Yang Sun, Laura Jeffrey, Zhonghu Bai, Brian McNeil, Linda M. Harvey, Yankun Yang, Wei Zhang, Xiuxia Liu
Publikováno v:
Critical Reviews in Biotechnology. 36:652-664
Corynebacterium glutamicum (C. glutamicum) is a highly promising alternative prokaryotic host for recombinant protein expression, as it possesses several significant advantages over Escherichia coli (E. coli), the currently leading bacterial protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69177e6fdaec078392f9b255d869b49c
https://doi.org/10.3109/07388551.2015.1004519
https://doi.org/10.3109/07388551.2015.1004519
Autor:
Robert Smith, Jamie Young, David Kirkland, Paul L. Carmichael, Stefan Pfuhler, Laura Jeffrey, Katie Smith, Paul Fowler
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 767:28-36
We have demonstrated previously that the seemingly high rate of “false” or “misleading” positive results from in vitro micronucleus assays (MNvit) was greater when rodent derived cell lines and certain toxicity measures, such as relative cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d09653b377560a6e600db8e389efb8
https://doi.org/10.1016/j.mrgentox.2014.03.001
https://doi.org/10.1016/j.mrgentox.2014.03.001
Autor:
Robert Smith, Laura Jeffrey, Paul Fowler, Paul L. Carmichael, Katie Smith, David Kirkland, Jamie Young, Stefan Pfuhler
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 747:104-117
In a previous publication, Fowler et al. [4] demonstrated that the seemingly high rate of false or misleading positive results obtained in in vitro cytogenesis assays for genotoxicity - when compared with in vivo genotoxicity or rodent carcinogenicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb82948b9c1796cf1c8064598343070
https://doi.org/10.1016/j.mrgentox.2012.04.013
https://doi.org/10.1016/j.mrgentox.2012.04.013
Autor:
Paul L. Carmichael, Katie Smith, Laura Jeffrey, Jamie Young, Paul Fowler, Stefan Pfuhler, David Kirkland
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 742:11-25
Current in vitro mammalian cell genotoxicity assays show a high rate of positive results, many of which are misleading when compared with in vivo genotoxicity or rodent carcinogenicity data. P53-deficiency in many of the rodent cell lines may be a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::451700dfa05b43f74c00a2cd549fb6a8
https://doi.org/10.1016/j.mrgentox.2011.10.014
https://doi.org/10.1016/j.mrgentox.2011.10.014
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 702:175-180
The following genotoxic chemicals were tested in the in vitro micronucleus assay, at Covance Laboratories, Harrogate, UK in the Chinese hamster lung cell line CHL. Etoposide (a topoisomerase inhibitor), colchicine (an aneugen), mitomycin C (a DNA cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15ef0322148e06348a62aa56b74cb56
https://doi.org/10.1016/j.mrgentox.2010.02.018
https://doi.org/10.1016/j.mrgentox.2010.02.018
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 702:171-174
The following genotoxic chemicals were tested in the in vitro micronucleus assay, at Covance Laboratories, Harrogate, UK in the human lymphoblastoid cell line TK6. Cadmium chloride (an inorganic carcinogen), benzo[a]pyrene (a polycyclic aromatic hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a236ac8769a9c6eabc0b0d10e3fef314
https://doi.org/10.1016/j.mrgentox.2010.02.016
https://doi.org/10.1016/j.mrgentox.2010.02.016
Autor:
Debbie Wood, Laura Jeffrey, David Kirkland, Karen Jenner, James Whitwell, Jamie Young, Sarah Allars, Paul Fowler, Katie Smith, Melvyn Lloyd
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 702:237-247
The reference genotoxic agents 2-aminoanthracene (a metabolism dependent weak clastogen), 5-fluorouracil (a nucleoside analogue, characterised by a steep dose response profile), colchicine (an aneugen that inhibits tubulin polymerisation), benzo[a]py
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec4e581f4d66a2844d06be9405d1a8a
https://doi.org/10.1016/j.mrgentox.2010.05.004
https://doi.org/10.1016/j.mrgentox.2010.05.004
Autor:
Paul Fowler, Karen Jenner, Jamie Young, Sarah Allars, Debbie Wood, James Whitwell, Melvyn Lloyd, David Kirkland, Laura Jeffrey, Katie Smith
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 702:230-236
The reference genotoxic agents 5-fluorouracil (a nucleoside analogue, characterised by a steep dose response profile), colchicine (an aneugen that inhibits tubulin polymerisation), benzo[a]pyrene (a polycyclic aromatic hydrocarbon requiring metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::917680d7a64852472cbf29f8bbfcef9b
https://doi.org/10.1016/j.mrgentox.2010.04.022
https://doi.org/10.1016/j.mrgentox.2010.04.022