Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Laura Jeacock"'
Publikováno v:
eLife, Vol 7 (2018)
Protein abundance differs from a few to millions of copies per cell. Trypanosoma brucei presents an excellent model for studies on codon bias and differential gene expression because transcription is broadly unregulated and uniform across the genome.
Externí odkaz:
https://doaj.org/article/79e9ebb5253f460ebae2af929051bfef
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006307 (2017)
Aquaglyceroporins (AQPs) transport water and glycerol and play important roles in drug-uptake in pathogenic trypanosomatids. For example, AQP2 in the human-infectious African trypanosome, Trypanosoma brucei gambiense, is responsible for melarsoprol a
Externí odkaz:
https://doaj.org/article/3a00db504e65484d9c721ae4a0b49749
Publikováno v:
PLoS Pathogens, Vol 12, Iss 2, p e1005436 (2016)
The chemotherapeutic arsenal against human African trypanosomiasis, sleeping sickness, is limited and can cause severe, often fatal, side effects. One of the classic and most widely used drugs is pentamidine, an aromatic diamidine compound introduced
Externí odkaz:
https://doaj.org/article/a8171a65f1ec4de58b28e81dc3c20717
Autor:
Alasdair Smith, Richard J. Wall, Stephen Patterson, Tim Rowan, Eva Rico Vidal, Laste Stojanovski, Margaret Huggett, Shahienaz E. Hampton, Michael G. Thomas, Victoriano Corpas Lopez, Kirsten Gillingwater, Jeff Duke, Grant Napier, Rose Peter, Hervé S. Vitouley, Justin R. Harrison, Rachel Milne, Laura Jeacock, Nicola Baker, Susan H. Davis, Frederick Simeons, Jennifer Riley, David Horn, Reto Brun, Fabio Zuccotto, Michael J Witty, Susan Wyllie, Kevin D. Read, Ian H. Gilbert
Publikováno v:
Journal of medicinal chemistry. 65(7)
African animal trypanosomiasis or nagana, caused principally by infection of the protozoan parasites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacc947c0ce396c65efecec5afe51f2c
https://pubmed.ncbi.nlm.nih.gov/35303411
https://pubmed.ncbi.nlm.nih.gov/35303411
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
The Cas9 endonuclease can be programmed by guide RNA to introduce sequence-specific breaks in genomic DNA. Thus, Cas9-based approaches present a range of novel options for genome manipulation and precision editing. African trypanosomes are parasites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c2532bf4d1cdb5367b728555b86094a5
http://link.springer.com/article/10.1038/s41598-018-26303-w
http://link.springer.com/article/10.1038/s41598-018-26303-w
Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 12, Iss 2, p e1005436 (2016)
PLoS Pathogens, Vol 12, Iss 2, p e1005436 (2016)
The chemotherapeutic arsenal against human African trypanosomiasis, sleeping sickness, is limited and can cause severe, often fatal, side effects. One of the classic and most widely used drugs is pentamidine, an aromatic diamidine compound introduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a4b8d2dd4f52fbfe58f77302d4dcc7
http://europepmc.org/articles/PMC4734766
http://europepmc.org/articles/PMC4734766
Autor:
Rick M. Maizels, Frederick van Deursen, Keith R. Matthews, Laura Jeacock, Eleanor M. Barnwell, Alvaro Acosta-Serrano, Katherine A. Smith
Publikováno v:
Barnwell, E M, van Deursen, F J, Jeacock, L, Smith, K A, Maizels, R M, Acosta-Serrano, A & Matthews, K 2010, ' Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms ', Journal of Cell Science, vol. 123, no. 19, pp. 3401-11 . https://doi.org/10.1242/jcs.068684
Trypanosomes evade host immunity by exchanging variant surface glycoprotein (VSG) coats. VSG genes are transcribed from telomeric expression sites, which contain a diverse family of expression-site-associated genes (ESAGs). We have discovered that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6928f99c912f630e42be6c4bfcc857f
https://doi.org/10.1242/jcs.068684
https://doi.org/10.1242/jcs.068684