Výsledky vyhledávání - "Laura J.P. Latimer"

Maternal vaccination with a novel chimeric glycoprotein formulated with a polymer-based adjuvant provides protection from human parainfluenza virus type 3 in newborn lambs

Autor: S. van Drunen Littel-van den Hurk, Ravendra Garg, Andrew A. Potter, Susantha Gomis, Laura J.P. Latimer, Volker Gerdts

Publikováno v: Antiviral Research. 162:54-60

Human parainfluenza virus 3 (PIV3) and respiratory syncytial virus (RSV) are major causative agents of serious respiratory tract illness in newborns and infants. Maternal vaccination could be a promising approach to provide immediate protection again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3a27db51150cd33f6cd9a43af1d90e
https://doi.org/10.1016/j.antiviral.2018.12.010

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Vaccination with a human parainfluenza virus type 3 chimeric FHN glycoprotein formulated with a combination adjuvant induces protective immunity

Autor: S. van Drunen Littel-van den Hurk, Volker Gerdts, Andrew A. Potter, Ravendra Garg, Robert Brownlie, Laura J.P. Latimer

Publikováno v: Vaccine. 35:7139-7146

Human parainfluenza virus type 3 (PIV3) is a major cause of lower respiratory disease i.e. bronchitis, bronchiolitis or pneumonia, in infants and young children. Presently there is no licensed vaccine against PIV3. To produce an effective subunit vac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40c4a4f4131ba7042aff48b638f9eca
https://doi.org/10.1016/j.vaccine.2017.10.095

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Intranasal immunization with a single dose of the fusion protein formulated with a combination adjuvant induces long-term protective immunity against respiratory syncytial virus

Autor: Volker Gerdts, Ravendra Garg, Andrew A. Potter, S. van Drunen Littel-van den Hurk, Laura J.P. Latimer

Publikováno v: Human Vaccines & Immunotherapeutics

Respiratory syncytial virus (RSV) is the most common cause of respiratory tract infections in both children and elderly people. In this study we evaluated the short- and long-term protective efficacy of a single intranasal (IN) immunization with a RS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a51b008092b228d6492d1367b98e0a8
http://europepmc.org/articles/PMC5718833

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Maternal immunization with respiratory syncytial virus fusion protein formulated with a novel combination adjuvant provides protection from RSV in newborn lambs

Autor: Ravendra Garg, Y. Wang, Volker Gerdts, Elemir Simko, S. van Drunen Littel-van den Hurk, Andrew A. Potter, Laura J.P. Latimer

Publikováno v: Vaccine. 34:261-269

Respiratory syncytial virus (RSV) is the causative agent of serious upper and lower respiratory tract infections in newborns and infants. Protection from RSV is crucial for neonates, and maternal immunization is one approach that holds promise for pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fdf12773e06b28157e4eed117af345
https://doi.org/10.1016/j.vaccine.2015.11.029

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A chimeric glycoprotein formulated with a combination adjuvant induces protective immunity against both human respiratory syncytial virus and parainfluenza virus type 3

Autor: Laura J.P. Latimer, Robert Brownlie, Andrew A. Potter, Volker Gerdts, S. van Drunen Littel-van den Hurk, Ravendra Garg

Publikováno v: Antiviral research. 158

Human respiratory syncytial virus (RSV) and parainfluenza virus type 3 (PIV3) are major causes of serious lower respiratory tract disease in infants. Currently there is no licensed vaccine against RSV or PIV3. To make an effective bivalent subunit va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1b841ea5a731f3a5aeb833b2579cf6
https://pubmed.ncbi.nlm.nih.gov/30071204

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Vaccination with the RSV fusion protein formulated with a combination adjuvant induces long-lasting protective immunity

Autor: Volker Gerdts, S. van Drunen Littel-van den Hurk, Andrew A. Potter, Laura J.P. Latimer, Ravendra Garg

Publikováno v: Journal of General Virology. 95:1043-1054

Respiratory syncytial virus (RSV) is one of the primary causative agents of upper and lower respiratory tract infections in young children, in particular infants. Recently, we reported the protective efficacy of a RSV vaccine formulation consisting o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b9ffb5ed732df4256b350084a061b2
https://doi.org/10.1099/vir.0.062570-0

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The respiratory syncytial virus fusion protein formulated with a novel combination adjuvant induces balanced immune responses in lambs with maternal antibodies

Autor: Volker Gerdts, Ravendra Garg, S. van Drunen Littel-van den Hurk, Laura J.P. Latimer, Andrew A. Potter

Publikováno v: Vaccine. 33(11)

Respiratory syncytial virus (RSV) causes severe respiratory illness in infants. There are no licensed vaccines to prevent RSV infection. The neonate receives short-term protection from maternally derived antibodies, which, however, can also interfere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0e615b2fdf94127af057b340b341ca
https://pubmed.ncbi.nlm.nih.gov/25637860

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Immunogenicity of a bovine herpesvirus 1 glycoprotein D DNA vaccine complexed with bovine neutrophil beta-defensin 3

Autor: Ethel Atanley, Sam K. Attah-Poku, Jennifer Kovacs-Nolan, Lorne A. Babiuk, Laura J.P. Latimer, Sarah Mackenzie-Dyck, Sylvia van Drunen Littel-van den Hurk

Publikováno v: Clinical and vaccine immunology : CVI. 22(1)

Protective efficacy against bovine herpesvirus 1 (BoHV-1) has been demonstrated to be induced by a plasmid encoding bovine neutrophil beta-defensin 3 (BNBD3) as a fusion construct with truncated glycoprotein D (tgD). However, in spite of the increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7601e99a2e288d9e8095dd0db069c9
https://pubmed.ncbi.nlm.nih.gov/25378352

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Priming by DNA immunization augments T-cell responses induced by modified live bovine herpesvirus vaccine

Autor: B. I. Loehr, Reno Pontarollo, Robert Rankin, Laura J.P. Latimer, S. van Drunen Littel-van den Hurk, Lorne A. Babiuk, P. Willson

Publikováno v: Journal of General Virology. 82:3035-3043

DNA vaccines have several advantages over conventional vaccines. One of the most important characteristics is the presentation of antigen via both MHC class I and class II receptors. Although this generally results in strong T-cell responses, antibod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c664d2296dc07bcd247720cb6589cfd
https://doi.org/10.1099/0022-1317-82-12-3035

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Induction of mucosal immunity and protection by intranasal immunization with a respiratory syncytial virus subunit vaccine formulation

Autor: Andrew A. Potter, Ravendra Garg, Elemir Simko, S. van Drunen Littel-van den Hurk, Volker Gerdts, Laura J.P. Latimer

Publikováno v: The Journal of general virology. 95(Pt 2)

The majority of infections, including those caused by respiratory syncytial virus (RSV), occur at mucosal surfaces. As no RSV vaccine is available our goal is to produce an effective subunit vaccine with an adjuvant suitable for mucosal delivery and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c89f15eec03d85ac089b693468e993
https://pubmed.ncbi.nlm.nih.gov/24136365

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