Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Laura J. Norton"'
Autor:
Alexander J. Knights, Emily J. Vohralik, Peter J. Houweling, Elizabeth S. Stout, Laura J. Norton, Stephanie J. Alexopoulos, Jinfen. J. Yik, Hanapi Mat Jusoh, Ellen M. Olzomer, Kim S. Bell-Anderson, Kathryn N. North, Kyle L. Hoehn, Merlin Crossley, Kate G. R. Quinlan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Immune cells are important regulators of adipose tissue function, including adaptive thermogenesis. Here the authors show that mice with Krüppel-like factor 3 (KLF3) deficiency in bone marrow-derived cells have increased adipose tissue beiging which
Externí odkaz:
https://doaj.org/article/c3cf746046c44c4288224f72b4e3c524
Autor:
Laura J. Norton, Samantha Hallal, Elizabeth S. Stout, Alister P. W. Funnell, Richard C. M. Pearson, Merlin Crossley, Kate G. R. Quinlan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The Krüppel-like factor (KLF) family of transcription factors play critical roles in haematopoiesis. KLF1, the founding member of the family, has been implicated in the control of both erythropoiesis and megakaryopoiesis. Here we describe a
Externí odkaz:
https://doaj.org/article/a37d4ae2beb44fd8a42326855e39b724
KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells
Autor:
Laura J. Norton, Alister P.W. Funnell, Jon Burdach, Beeke Wienert, Ryo Kurita, Yukio Nakamura, Sjaak Philipsen, Richard C.M. Pearson, Kate G.R. Quinlan, Merlin Crossley
Publikováno v:
Blood Advances, Vol 1, Iss 11, Pp 685-692 (2017)
Abstract: Genes encoding the human β-like hemoglobin proteins undergo a developmental switch from fetal γ-globin to adult β-globin expression around the time of birth. β-hemoglobinopathies, such as sickle-cell disease and β-thalassemia, result f
Externí odkaz:
https://doaj.org/article/127389a1449942409be43fa25db88e07
Publikováno v:
International Journal of Cell Biology, Vol 2011 (2011)
Haemoglobinopathies such as thalassaemia and sickle cell disease present a major health burden. Currently, the main forms of treatment for these diseases are packed red blood cell transfusions and the administration of drugs which act to nonspecifica
Externí odkaz:
https://doaj.org/article/bc1456c5e68640488a5ed89db7907bd5
Autor:
Adriano G. Rossi, Florian Wollweber, Marta Canel, Johanna Lilja, Barry McCormick, Leo M. Carlin, Jennifer M Felton, Takehiko Sasaki, Melina Michael, Sonja Vermeren, Laura J. Norton, Anne Astier, Helen E. Craig, Ian Dransfield, Ingeborg Hers, Johanna Ivaska, Julia Y. Chu, Matilda Toivakka
Publikováno v:
The Journal of Immunology Author Choice
McCormick, B, Craig, H E, Chu, J Y, Carlin, L M, Canel, M, Wollweber, F, Toivakka, M, Michael, M, Astier, A L, Norton, L, Lilja, J, Felton, J M, Sasaki, T, Ivaska, J, Hers, I, Dransfield, I, Rossi, A G & Vermeren, S 2019, ' A negative feedback loop regulates integrin inactivation and promotes neutrophil recruitment to inflammatory sites ', Journal of Immunology, vol. 203, no. 9 . https://doi.org/10.4049/jimmunol.1900443
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2019, 203 (6), pp.1579-1588. ⟨10.4049/jimmunol.1900443⟩
McCormick, B, Craig, H E, Chu, J Y, Carlin, L M, Canel, M, Wollweber, F, Toivakka, M, Michael, M, Astier, A L, Norton, L, Lilja, J, Felton, J M, Sasaki, T, Ivaska, J, Hers, I, Dransfield, I, Rossi, A G & Vermeren, S 2019, ' A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites ', Journal of Immunology, vol. 203, no. 6, pp. 1579-1588 . https://doi.org/10.4049/jimmunol.1900443
McCormick, B, Craig, H E, Chu, J Y, Carlin, L M, Canel, M, Wollweber, F, Toivakka, M, Michael, M, Astier, A L, Norton, L, Lilja, J, Felton, J M, Sasaki, T, Ivaska, J, Hers, I, Dransfield, I, Rossi, A G & Vermeren, S 2019, ' A negative feedback loop regulates integrin inactivation and promotes neutrophil recruitment to inflammatory sites ', Journal of Immunology, vol. 203, no. 9 . https://doi.org/10.4049/jimmunol.1900443
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2019, 203 (6), pp.1579-1588. ⟨10.4049/jimmunol.1900443⟩
McCormick, B, Craig, H E, Chu, J Y, Carlin, L M, Canel, M, Wollweber, F, Toivakka, M, Michael, M, Astier, A L, Norton, L, Lilja, J, Felton, J M, Sasaki, T, Ivaska, J, Hers, I, Dransfield, I, Rossi, A G & Vermeren, S 2019, ' A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites ', Journal of Immunology, vol. 203, no. 6, pp. 1579-1588 . https://doi.org/10.4049/jimmunol.1900443
Key Points A negative feedback loop, integrin–PI3K–ARAP3–integrin, controls integrin inactivation. Integrin inactivation promotes neutrophil transendothelial migration and recruitment.
Neutrophils are abundant circulating leukocytes that a
Neutrophils are abundant circulating leukocytes that a
Autor:
Kate G. R. Quinlan, Jinfen J. Yik, Alexander J. Knights, Hanapi Mat Jusoh, Peter J. Houweling, Kyle L. Hoehn, Laura J. Norton, Ellen M. Olzomer, Elizabeth S. Stout, Merlin Crossley, Kathryn N. North, Stephanie J. Alexopoulos, Emily J. Vohralik, Kim S. Bell-Anderson
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely und
Autor:
Merlin Crossley, Gamran S. Green, Kate G. R. Quinlan, Emily J. Vohralik, Alexander J. Knights, Lu Yang, Manan Shah, Elizabeth S. Stout, Laura J. Norton
Publikováno v:
J Biol Chem
Bacterial products such as lipopolysaccharides (or endotoxin) cause systemic inflammation, resulting in a substantial global health burden. The onset, progression, and resolution of the inflammatory response to endotoxin are usually tightly controlle
Autor:
Alister P. W. Funnell, Manan Shah, Richard C. M. Pearson, Laura J. Norton, Yukio Nakamura, Gabriella E. Martyn, Merlin Crossley, Jon Burdach, Lu Yang, Kate G. R. Quinlan, Beeke Wienert, Ryo Kurita
Publikováno v:
Nature Genetics. 50:498-503
β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia result from mutations in the adult HBB (β-globin) gene. Reactivating the developmentally silenced fetal HBG1 and HBG2 (γ-globin) genes is a therapeutic goal for treating SCD
Autor:
Alister P. W. Funnell, Laura J. Norton, Samantha Hallal, Richard C. M. Pearson, Kate G. R. Quinlan, Merlin Crossley, Elizabeth S. Stout
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
The Krüppel-like factor (KLF) family of transcription factors play critical roles in haematopoiesis. KLF1, the founding member of the family, has been implicated in the control of both erythropoiesis and megakaryopoiesis. Here we describe a novel sy