Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Laura J. Leighton"'
Autor:
Wei-Siang Liau, Qiongyi Zhao, Adekunle Bademosi, Rachel S. Gormal, Hao Gong, Paul R. Marshall, Ambika Periyakaruppiah, Sachithrani U. Madugalle, Esmi L. Zajaczkowski, Laura J. Leighton, Haobin Ren, Mason Musgrove, Joshua Davies, Simone Rauch, Chuan He, Bryan C. Dickinson, Xiang Li, Wei Wei, Frédéric A. Meunier, Sandra M. Fernández-Moya, Michael A. Kiebler, Balakumar Srinivasan, Sourav Banerjee, Michael Clark, Robert C. Spitale, Timothy W. Bredy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules that are involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are localized to the synapse; however, a direct role for t
Externí odkaz:
https://doaj.org/article/988e064ab265447988a0b34da83e4592
Autor:
Wei Wei, Qiongyi Zhao, Ziqi Wang, Wei-Siang Liau, Dean Basic, Haobin Ren, Paul R. Marshall, Esmi L. Zajaczkowski, Laura J. Leighton, Sachithrani U. Madugalle, Mason Musgrove, Ambika Periyakaruppiah, Jichun Shi, Jianjian Zhang, John S. Mattick, Timothy R. Mercer, Robert C. Spitale, Xiang Li, Timothy W. Bredy
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110546- (2022)
Summary: Here, we used RNA capture-seq to identify a large population of lncRNAs that are expressed in the infralimbic prefrontal cortex of adult male mice in response to fear-related learning. Combining these data with cell-type-specific ATAC-seq on
Externí odkaz:
https://doaj.org/article/780e722429aa497c8ef62de662ee166e
Autor:
Laura J. Leighton, Timothy W. Bredy
Publikováno v:
Non-Coding RNA, Vol 4, Iss 2, p 15 (2018)
Small non-coding RNAs are essential for transcription, translation and gene regulation in all cell types, but are particularly important in neurons, with known roles in neurodevelopment, neuroplasticity and neurological disease. Many small non-coding
Externí odkaz:
https://doaj.org/article/6277c6300092476092a75ad3c40563e6
Autor:
Paul R. Marshall, Qiongyi Zhao, Joshua Davies, Wei-Siang Liau, Yujin Lee, Dean Basic, Ambika Periyakaruppiah, Esmi L. Zajaczkowski, Laura J. Leighton, Sachithrani U. Madugalle, Mason Musgrove, Marcin Kielar, Hao Gong, Haobin Ren, Lech Kaczmarczyk, Walker S. Jackson, Alon Chen, Robert C. Spitale, Timothy W. Bredy
The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here we report that DNA G-quadruplex (G4-DNA) accumulates in neurons in an experience-dependent manner, and that this is required for the transient silencing an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c92f219ce356988d031421b1512a44d4
https://doi.org/10.1101/2023.01.09.523337
https://doi.org/10.1101/2023.01.09.523337
Autor:
Sachithrani U. Madugalle, Wei-Siang Liau, Qiongyi Zhao, Xiang Li, Hao Gong, Paul R. Marshall, Ambika Periyakaruppiah, Esmi L. Zajackowski, Laura J. Leighton, Haobin Ren, Mason Musgrove, Joshua Davies, Simone Rauch, Chuan He, Bryan C. Dickinson, Lee Fletcher, Barbora Fulopova, Stephen R. Williams, Robert C. Spitale, Timothy W. Bredy
SummaryThe RNA modification N6-methyladenosine (m6A) is critically involved in the regulation of gene activity underlying experience-dependent plasticity, and is necessary for the functional interplay between RNA and RNA binding proteins (RBPs) in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da48fb87699dfd061793e8594f370990
https://doi.org/10.1101/2022.06.07.495230
https://doi.org/10.1101/2022.06.07.495230
Autor:
Laura J. Leighton, Qiongyi Zhao, Paul R. Marshall, Sachithrani U. Madugalle, Angelo H. C. Chan, Mason R. B. Musgrove, Haobin Ren, Ambika Periyakaruppiah, Janette Edson, Wei Wei, Xiang Li, Robert C. Spitale, Timothy W. Bredy
C/D box small nucleolar RNAs (snoRNAs) comprise a class of small noncoding RNAs with important regulatory effects on cellular RNA function. Although it is well established that snoRNAs coordinate the post-transcriptional modification of pre-ribosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57644c8d27df38b8f78ff2329039ffb6
https://doi.org/10.1101/2022.05.09.491263
https://doi.org/10.1101/2022.05.09.491263
Autor:
Wei-Siang Liau, Qiongyi Zhao, Adekunle Bademosi, Rachel Gormal, Hao Gong, Paul R. Marshall, Ambika Periyakaruppiah, Sachithrani U. Madugalle, Esmi L. Zajackowski, Laura J. Leighton, Haobin Ren, Mason Musgrove, Joshua Davies, Simone Rauch, Chuan He, Bryan C. Dickinson, Xiang Li, Wei Wei, Frédéric A. Meunier, Sandra M. Fernandez Moya, Michael A. Kiebler, Bharath Srinivasan, Sourav Banerjee, Michael Clark, Robert C. Spitale, Timothy W. Bredy
SummaryLong noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are expressed at the synapse; however, a direct role for their activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eaf72765a02621455c60964b096ed74
https://doi.org/10.1101/2022.03.30.486308
https://doi.org/10.1101/2022.03.30.486308
Autor:
Sachithrani U. Madugalle, Ziqi Wang, Wei-Siang Liau, Esmi L. Zajaczkowski, Jichun Shi, John S. Mattick, Qiongyi Zhao, Laura J. Leighton, Tim R. Mercer, Haobin Ren, Paul R. Marshall, Xiang Li, Timothy W. Bredy, Wei Wei, Jianjian Zhang, Dean Basic, Mason Musgrove, Ambika Periyakaruppiah
Long-noncoding RNA (lncRNA) comprise a new class of genes that have been assigned key roles in development and disease. Many lncRNAs are specifically transcribed in the brain where they regulate the expression of protein-coding genes that underpin ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd63861dc1d377b513296ac130a389a0
https://doi.org/10.1101/2021.08.01.454607
https://doi.org/10.1101/2021.08.01.454607
Autor:
Thiago Wendt Viola, Ziqi Wang, Cathrine Broberg Vågbø, Christophe Magnan, Xiang Li, Sachithrani U. Madugalle, Jiayu Yin, Magnar Bjørås, Robert C. Spitale, Wei Wei, Esmi L. Zajaczkowski, Pierre Baldi, Qiongyi Zhao, Luis Eduardo Wearick-Silva, Rodrigo Grassi-Oliveira, Ke Ke, Laura J. Leighton, Timothy W. Bredy, Quan Lin, Paul R. Marshall, Sarah Nainar, Michael R. Emami
Publikováno v:
Nature neuroscience
DNA modification is known to regulate experience-dependent gene expression. However, beyond cytosine methylation and its oxidated derivatives, very little is known about the functional importance of chemical modifications on other nucleobases in the
Autor:
Paul R. Marshall, Laura J. Leighton, Qiongyi Zhao, Xia Li, Dean Basic, Timothy W. Bredy, Carl R. Walkley, Zhonghua Wang, Sachithrani U. Madugalle, Jiayu Yin, Wei Wei, Malathi A, Wei-Siang Liau, Esmi L. Zajaczkowski
RNA modification has recently emerged as an important mechanism underlying gene diversity linked to behavioral regulation. The conversion of adenosine to inosine by the ADAR family of enzymes is a particularly important RNA modification as it impacts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c4a1424b3eb7e7bbf05cc8ccac8aaa
https://doi.org/10.1101/641209
https://doi.org/10.1101/641209