Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Laura J. Le"'
Publikováno v:
Journal of Statistics and Data Science Education, Vol 31, Iss 3, Pp 286-294 (2023)
AbstractWe present a unique and innovative course, Biostatistical Literacy, developed at the University of Minnesota. The course is aimed at public health graduate students and health sciences professionals. Its goal is to develop students’ ability
Externí odkaz:
https://doaj.org/article/7dde93ba1e174f2aa8e8fa4ab4ad02b1
Autor:
Özkan İş, Xue Wang, Joseph S. Reddy, Yuhao Min, Elanur Yilmaz, Prabesh Bhattarai, Tulsi Patel, Jeremiah Bergman, Zachary Quicksall, Michael G. Heckman, Frederick Q. Tutor-New, Birsen Can Demirdogen, Launia White, Shunsuke Koga, Vincent Krause, Yasuteru Inoue, Takahisa Kanekiyo, Mehmet Ilyas Cosacak, Nastasia Nelson, Annie J. Lee, Badri Vardarajan, Richard Mayeux, Naomi Kouri, Kaancan Deniz, Troy Carnwath, Stephanie R. Oatman, Laura J. Lewis-Tuffin, Thuy Nguyen, for the Alzheimer’s Disease Neuroimaging Initiative, Minerva M. Carrasquillo, Jonathan Graff-Radford, Ronald C. Petersen, Clifford R. Jr Jack, Kejal Kantarci, Melissa E. Murray, Kwangsik Nho, Andrew J. Saykin, Dennis W. Dickson, Caghan Kizil, Mariet Allen, Nilüfer Ertekin-Taner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract To uncover molecular changes underlying blood-brain-barrier dysfunction in Alzheimer’s disease, we performed single nucleus RNA sequencing in 24 Alzheimer’s disease and control brains and focused on vascular and astrocyte clusters as mai
Externí odkaz:
https://doaj.org/article/0f4d86fabcd9496f8761615d7234bc5b
Autor:
Wei-Siang Liau, Qiongyi Zhao, Adekunle Bademosi, Rachel S. Gormal, Hao Gong, Paul R. Marshall, Ambika Periyakaruppiah, Sachithrani U. Madugalle, Esmi L. Zajaczkowski, Laura J. Leighton, Haobin Ren, Mason Musgrove, Joshua Davies, Simone Rauch, Chuan He, Bryan C. Dickinson, Xiang Li, Wei Wei, Frédéric A. Meunier, Sandra M. Fernández-Moya, Michael A. Kiebler, Balakumar Srinivasan, Sourav Banerjee, Michael Clark, Robert C. Spitale, Timothy W. Bredy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules that are involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are localized to the synapse; however, a direct role for t
Externí odkaz:
https://doaj.org/article/988e064ab265447988a0b34da83e4592
Autor:
Jing Zhao, Tadafumi C. Ikezu, Wenyan Lu, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis-Tuffin, Yuka A. Martens, Yingxue Ren, Yiyang Zhu, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Background The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear. The apoE protein is a major lipid carrier in the brain transporting li
Externí odkaz:
https://doaj.org/article/8961c4038dba4cdca8459cc85838feef
Autor:
Wan-Hsin Lin, Ryan W. Feathers, Lisa M. Cooper, Laura J. Lewis-Tuffin, Jiaxiang Chen, Jann N. Sarkaria, Panos Z. Anastasiadis
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Glioblastomas (GBM) are aggressive tumors that lack effective treatments. Here, we show that the Rho family guanine nucleotide exchange factor Syx promotes GBM cell growth both in vitro and in orthotopic xenografts derived from patients with GBM. Gro
Externí odkaz:
https://doaj.org/article/88293167408845f6a8a970ef58fbb1c5
Autor:
Muhammad Moid Khalid Khan, Subodh C. Deshmukh, Kanthan Theivendran, Laura J. Leslie, Sarah Junaid
Publikováno v:
IEEE Access, Vol 9, Pp 7021-7032 (2021)
Migration of an implanted prosthesis due to aseptic loosening is difficult to detect without regular imaging. In this paper, a low-cost, non-radiographic, robust diagnostic technique is presented, which can detect the migration of the humeral compone
Externí odkaz:
https://doaj.org/article/c2052c9dc1e243ed92fa423143502240
In the face of U.S. military superiority, potential adversaries have begun to turn to asymmetrical means as a way to counter that capability. Our adversaries understand that U.S.-led coalitions will dominate the battlespace, if given the opportunity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fea2165eb8f6d523f0a089ca227be75a
https://doi.org/10.21236/ada446158
https://doi.org/10.21236/ada446158
Autor:
Wei Wei, Qiongyi Zhao, Ziqi Wang, Wei-Siang Liau, Dean Basic, Haobin Ren, Paul R. Marshall, Esmi L. Zajaczkowski, Laura J. Leighton, Sachithrani U. Madugalle, Mason Musgrove, Ambika Periyakaruppiah, Jichun Shi, Jianjian Zhang, John S. Mattick, Timothy R. Mercer, Robert C. Spitale, Xiang Li, Timothy W. Bredy
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110546- (2022)
Summary: Here, we used RNA capture-seq to identify a large population of lncRNAs that are expressed in the infralimbic prefrontal cortex of adult male mice in response to fear-related learning. Combining these data with cell-type-specific ATAC-seq on
Externí odkaz:
https://doaj.org/article/780e722429aa497c8ef62de662ee166e
Autor:
Dah-eun Chloe Chung, Yari Carlomagno, Casey N. Cook, Karen Jansen-West, Lillian Daughrity, Laura J. Lewis-Tuffin, Monica Castanedes-Casey, Michael DeTure, Dennis W. Dickson, Leonard Petrucelli
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-12 (2019)
Abstract Tauopathies are neurodegenerative disorders characterized by aggregation of microtubule associated tau protein in neurons and glia. They are clinically and pathologically heterogeneous depending on the isoform of tau protein that accumulates
Externí odkaz:
https://doaj.org/article/76089d87ed404a068675109efa344743
Autor:
Laura J. Lee Kemp
Publikováno v:
Belphégor, Vol 15, Iss 2 (2017)
Films set during or immediately after the Spanish Civil War have a long tradition in Spain, one which spans the entire spectrum of filmic genres, from propaganda to musicals to art-house. This genre has not abated since the turn of the century, it ha
Externí odkaz:
https://doaj.org/article/25b31d0b49f84e6e9e2059db03d06690