Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Laura J. Gay"'
Autor:
Michal Marek Hoppe, Patrick Jaynes, Fan Shuangyi, Yanfen Peng, Shruti Sridhar, Phuong Mai Hoang, Clementine Xin Liu, Sanjay De Mel, Limei Poon, Esther Hian Li Chan, Joanne Lee, Choon Kiat Ong, Tiffany Tang, Soon Thye Lim, Chandramouli Nagarajan, Nicholas F. Grigoropoulos, Soo-Yong Tan, Susan Swee-Shan Hue, Sheng-Tsung Chang, Shih-Sung Chuang, Shaoying Li, Joseph D. Khoury, Hyungwon Choi, Carl Harris, Alessia Bottos, Laura J. Gay, Hendrik F.P. Runge, Ilias Moutsopoulos, Irina Mohorianu, Daniel J. Hodson, Pedro Farinha, Anja Mottok, David W. Scott, Jason J. Pitt, Jinmiao Chen, Gayatri Kumar, Kasthuri Kannan, Wee Joo Chng, Yen Lin Chee, Siok-Bian Ng, Claudio Tripodo, Anand D. Jeyasekharan
Publikováno v:
Cancer Discovery. 13:1144-1163
Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if combinations of oncogenes in cellular subpopulations within a cancer influence clinical outcomes. Using quantitative multispectral imaging of the prognostically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab2f4b4f328881ed500c6ebd12169c1
https://doi.org/10.1158/2159-8290.cd-22-0998
https://doi.org/10.1158/2159-8290.cd-22-0998
Autor:
Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe
Supplementary methods. Supplementary Figure 1. Phenotyping of B-cells in non-malignant tissues. A, Quantitation of marker positivity across ten tonsil and two reactive lymph node samples (rLN). Analysis is spatially resolved between the GC and extra-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1384ca4754d093f025ce1a0291e89e
https://doi.org/10.1158/2159-8290.22758717.v1
https://doi.org/10.1158/2159-8290.22758717.v1
Data from Patterns of Oncogene Coexpression at Single-Cell Resolution Influence Survival in Lymphoma
Autor:
Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe
Cancers often overexpress multiple clinically relevant oncogenes, but it is not known if combinations of oncogenes in cellular subpopulations within a cancer influence clinical outcomes. Using quantitative multispectral imaging of the prognostically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ce1b219efa31d7bf84a26b29d07845
https://doi.org/10.1158/2159-8290.c.6605362.v2
https://doi.org/10.1158/2159-8290.c.6605362.v2
Autor:
Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe
Quantitative single-cell analysis of MYC, BCL2, and BCL6 protein expression in B cells in nonmalignant tissues and diffuse large B-cell lymphoma. A, Schematic workflow of a quantitative digital pathology experiment. B, Spectrally unmixed multiplexed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edec01ecde3920ad644e2b75f7b45d5
https://doi.org/10.1158/2159-8290.22758738.v1
https://doi.org/10.1158/2159-8290.22758738.v1
Autor:
Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe
Transcriptomic analysis of M+2+6− high cases and potential role of CCND2. A, Correlation of observed M+2+6− percentage extent in the BCA cohort with the cell-of-origin (COO) DLBCL90-COO signature. Bonferroni corrected Kruskal–Wallis test for AB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb1210be63082ca37f36878b6dff1be
https://doi.org/10.1158/2159-8290.22758723
https://doi.org/10.1158/2159-8290.22758723
Autor:
Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe
Multivariate analysis of continuous M+2+6− percentage extent at 5% increments as a predictor of OS in the NUH, SGH, and MDA cohorts of DLBCL (Cox proportional hazards model)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b307777b77b384a807f96c86c3ec51
https://doi.org/10.1158/2159-8290.22758711.v1
https://doi.org/10.1158/2159-8290.22758711.v1
Autor:
Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris III, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe
Supplementary table 1. Per-patient mfIHC MYC, BCL2 and BCL6 single oncogene and subpopulation scores for normal tonsil tissue and reactive lymph node tissue. Supplementary table 2. Per-patient mfIHC MYC, BCL2 and BCL6 single oncogene and subpopulatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff9a247008cdaa68fe7a25b087809ad
https://doi.org/10.1158/2159-8290.22758714
https://doi.org/10.1158/2159-8290.22758714
Autor:
Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe
MYC, BCL2, and BCL6 protein coexpression in DLBCL can be inferred from individual marker data. A, Schematic of possible relationships between expression of three oncogenes in a population of cells. The distribution of these oncogenes can either refle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6694892f196e5834d91b4148e365eee4
https://doi.org/10.1158/2159-8290.22758732.v1
https://doi.org/10.1158/2159-8290.22758732.v1
Autor:
Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe
Validation of prognostic significance of the M+2+6− subpopulation metric in gene-expression datasets. A, Distribution of single oncogene positivity in DLBCL cohorts as assessed by mfIHC (see Supplementary Fig. S9A and S9B). B, Impact of subpopulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb63581f5ecbf61615fc7943128a009
https://doi.org/10.1158/2159-8290.22758729
https://doi.org/10.1158/2159-8290.22758729
Autor:
Anand D. Jeyasekharan, Claudio Tripodo, Siok-Bian Ng, Yen Lin Chee, Wee Joo Chng, Kasthuri Kannan, Gayatri Kumar, Jinmiao Chen, Jason J. Pitt, David W. Scott, Anja Mottok, Pedro Farinha, Daniel J. Hodson, Irina Mohorianu, Ilias Moutsopoulos, Hendrik F.P. Runge, Laura J. Gay, Alessia Bottos, Carl Harris, Hyungwon Choi, Joseph D. Khoury, Shaoying Li, Shih-Sung Chuang, Sheng-Tsung Chang, Susan Swee-Shan Hue, Soo-Yong Tan, Nicholas F. Grigoropoulos, Chandramouli Nagarajan, Soon Thye Lim, Tiffany Tang, Choon Kiat Ong, Joanne Lee, Esther Hian Li Chan, Limei Poon, Sanjay De Mel, Clementine Xin Liu, Phuong Mai Hoang, Shruti Sridhar, Yanfen Peng, Fan Shuangyi, Patrick Jaynes, Michal Marek Hoppe
Prognostic significance of subpopulations after R-CHOP therapy. A, Pooled univariate Cox PH model analysis for MYC, BCL2, and BCL6 single oncogene and subpopulations percentage extent as predictors of OS across multiple DLBCL cohorts. Percentage exte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f448b9d1c8cd0cc357aa6da6444477
https://doi.org/10.1158/2159-8290.22758735.v1
https://doi.org/10.1158/2159-8290.22758735.v1