Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Laura J. A. Hardwick"'
Autor:
Laura J. A. Hardwick, Anna Philpott
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
The use of the Xenopus model system has provided diverse contributions to cancer research, not least because of the striking parallels between tumour pathogenesis and early embryo development. Cell cycle regulation, signalling pathways, and cell beha
Externí odkaz:
https://doaj.org/article/782930d5a8e94996a327f373736ee9cf
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 5, Pp 429-441 (2015)
Neuroblastoma (NB), although rare, accounts for 15% of all paediatric cancer mortality. Unusual among cancers, NBs lack a consistent set of gene mutations and, excluding large-scale chromosomal rearrangements, the genome seems to be largely intact. I
Externí odkaz:
https://doaj.org/article/1d58570c9f084c67bb43b76944016fa0
Autor:
Laura J A, Hardwick, Anna, Philpott
Publikováno v:
Cold Spring Harbor protocols. 2019(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87be9a5efede369991c4a76339ff46cf
https://pubmed.ncbi.nlm.nih.gov/31138717
https://pubmed.ncbi.nlm.nih.gov/31138717
Autor:
Laura J A, Hardwick, Anna, Philpott
Publikováno v:
Cold Spring Harbor protocols. 2019(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a070b28ef45778a7dc04093616d9db9f
https://pubmed.ncbi.nlm.nih.gov/31138716
https://pubmed.ncbi.nlm.nih.gov/31138716
Publikováno v:
Biochemical and Biophysical Research Communications
The superfamily of basic-Helix-Loop-Helix (bHLH) transcription factors influence cell fate in all three embryonic germ layers, and the tissue-specific class II factors have received prominent attention for their potent ability to direct differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f5b04c797d18ca91c99b9e9fda16508
https://pubmed.ncbi.nlm.nih.gov/30773262
https://pubmed.ncbi.nlm.nih.gov/30773262
Autor:
Laura J A, Hardwick, Anna, Philpott
Publikováno v:
Biochemical and Biophysical Research Communications
The processes of cell proliferation and differentiation are intimately linked during embryogenesis, and the superfamily of (basic) Helix-Loop-Helix (bHLH) transcription factors play critical roles in these events. For example, neuronal differentiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22fd04dcb971e1376c7fc21c31569d2a
https://pubmed.ncbi.nlm.nih.gov/30600182
https://pubmed.ncbi.nlm.nih.gov/30600182
Autor:
Laura J A, Hardwick, Anna, Philpott
Publikováno v:
Wellcome Open Research
The proneural basic-helix-loop-helix (bHLH) transcription factor Ascl1 is a master regulator of neurogenesis in both central and peripheral nervous systems in vivo, and is a central driver of neuronal reprogramming in vitro. Over the last three decad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4367b5e515bf9f31af7ef6b575aac28
https://pubmed.ncbi.nlm.nih.gov/30363793
https://pubmed.ncbi.nlm.nih.gov/30363793
Autor:
Laura J A, Hardwick, Anna, Philpott
Publikováno v:
Developmental Biology
One of the most striking features of the Xenopus system is the versatility in providing a unique range of both in vitro and in vivo models that are rapid, accessible and easily manipulated. Here we present an overview of the diverse contribution that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62a3be793eae7d0a8f88e90986099d59
https://pubmed.ncbi.nlm.nih.gov/25704511
https://pubmed.ncbi.nlm.nih.gov/25704511
Publikováno v:
Disease Models & Mechanisms
Neuroblastoma (NB), although rare, accounts for 15% of all paediatric cancer mortality. Unusual among cancers, NBs lack a consistent set of gene mutations and, excluding large-scale chromosomal rearrangements, the genome seems to be largely intact. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32c3aba351e74c85d42cb5508002de2b
https://pubmed.ncbi.nlm.nih.gov/25786414
https://pubmed.ncbi.nlm.nih.gov/25786414
Publikováno v:
Biochemical and Biophysical Research Communications
Highlights • Although closely related, Ngn2 is rapidly degraded whereas NeuroD is stable. • NeuroD is ubiquitylated but not degraded. • The N-terminal domain of NeuroD confers stability. • Conserved bHLHs of Ngn2 and NeuroD promote instabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d268d72245208f2a97368fcf9a6445e
https://pubmed.ncbi.nlm.nih.gov/24998442
https://pubmed.ncbi.nlm.nih.gov/24998442