Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Laura J V, Piddock"'
Autor:
Biljana Kakaraskoska Boceska, Tuba Vilken, Basil Britto Xavier, Tomislav Kostyanev, Qiang Lin, Christine Lammens, Sally Ellis, Seamus O’Brien, Renata Maria Augusto da Costa, Aislinn Cook, Neal Russell, Julia Bielicki, Amy Riddell, Wolfgang Stohr, Ann Sarah Walker, Eitan Naaman Berezin, Emmanuel Roilides, Maia De Luca, Lorenza Romani, Daynia Ballot, Angela Dramowski, Jeannette Wadula, Sorasak Lochindarat, Suppawat Boonkasidecha, Flavia Namiiro, Hoang Thi Bich Ngoc, Minh Dien Tran, Tim R. Cressey, Kanchana Preedisripipat, James A. Berkley, Robert Musyimi, Charalampos Zarras, Trusha Nana, Andrew Whitelaw, Cely Barreto da Silva, Prenika Jaglal, Willy Ssengooba, Samir K. Saha, Mohammad Shahidul Islam, Marisa Marcia Mussi-Pinhata, Cristina Gardonyi Carvalheiro, Laura J. V. Piddock, Paul T. Heath, Surbhi Malhotra-Kumar, Michael Sharland, Youri Glupczynski, Herman Goossens
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Gram-negative bacteria (GNB) are a major cause of neonatal sepsis in low- and middle-income countries (LMICs). Although the World Health Organization (WHO) reports that over 80% of these sepsis deaths could be prevented through improved trea
Externí odkaz:
https://doaj.org/article/96086d94019d4d67999839b0ced29734
Autor:
Isaac, Weldon, Susan, Rogers Van Katwyk, Gian Luca, Burci, Dr, Giur, Thana C, de Campos, Mark, Eccleston-Turner, Helen R, Fryer, Alberto, Giubilini, Thomas, Hale, Mark, Harrison, Stephanie, Johnson, Claas, Kirchhelle, Kelley, Lee, Kathleen, Liddell, Marc, Mendelson, Gorik, Ooms, James, Orbinski, Laura J V, Piddock, John-Arne, Røttingen, Julian, Savulescu, Andrew C, Singer, A M, Viens, Clare, Wenham, Mary E, Wiktorowicz, Shehla, Zaidi, Steven J, Hoffman
Publikováno v:
American journal of public health. 112(4)
Autor:
Alessia Savoldi, Elena Carrara, Laura J. V. Piddock, Francois Franceschi, Sally Ellis, Margherita Chiamenti, Damiano Bragantini, Elda Righi, Evelina Tacconelli
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Effective treatment of sepsis due to carbapenem-resistant Gram-negative bacteria (CR-GNB) remains a challenge for clinicians worldwide. In recent years, the combination of antibiotics has become the preferred treatment strategy fo
Externí odkaz:
https://doaj.org/article/58c0b235e9024a74af9db72548085ad1
Autor:
Eamonn Reading, Zainab Ahdash, Chiara Fais, Vito Ricci, Xuan Wang-Kan, Elizabeth Grimsey, Jack Stone, Giuliano Malloci, Andy M. Lau, Heather Findlay, Albert Konijnenberg, Paula J. Booth, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock, Argyris Politis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
AcrB is a prototypical resistance–nodulation–division (RND) bacterial transporter, conferring resistance to a variety of antibiotics. HDX-MS and other, complementary approaches offer insight into AcrB structural dynamics and suggest the molecular
Externí odkaz:
https://doaj.org/article/f67d2dabeba6419d899fd8c49aa914be
Autor:
Xuan Wang-Kan, Giovanny Rodríguez-Blanco, Andrew D. Southam, Catherine L. Winder, Warwick B. Dunn, Alasdair Ivens, Laura J. V. Piddock
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Multidrug-resistant Gram-negative bacteria pose a global threat to human health. The AcrB efflux pump confers inherent and evolved drug resistance to EnterobacteralesEscherichia coliSalmonella enterica
Externí odkaz:
https://doaj.org/article/986045510b894ff9937b9ecb4c487418
Autor:
Jessica M A Blair, Pauline Siasat, Helen E McNeil, Abigail Colclough, Vito Ricci, Amelia J Lawler, Hind Abdalaal, Michelle M C Buckner, Alison Baylay, Stephen J Busby, Laura J V Piddock
Publikováno v:
Journal of Antimicrobial Chemotherapy. 78:133-140
Background Resistance nodulation division (RND) family efflux pumps, including the major pump AcrAB-TolC, are important mediators of intrinsic and evolved antibiotic resistance. Expression of these pumps is carefully controlled by a network of regula
Autor:
Robert L. Marshall, Georgina S. Lloyd, Amelia J. Lawler, Sarah J. Element, Jaswant Kaur, Maria Laura Ciusa, Vito Ricci, Andreas Tschumi, Holger Kühne, Luke J. Alderwick, Laura J. V. Piddock
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Active efflux of antibiotics preventing their accumulation to toxic intracellular concentrations contributes to clinically relevant multidrug resistance. Inhibition of active efflux potentiates antibiotic activity, indicating that efflux inh
Externí odkaz:
https://doaj.org/article/2629c888b070459bbab02735e914fc43
Autor:
Elizabeth M. Grimsey, Chiara Fais, Robert L. Marshall, Vito Ricci, Maria Laura Ciusa, Jack W. Stone, Alasdair Ivens, Giuliano Malloci, Paolo Ruggerone, Attilio V. Vargiu, Laura J. V. Piddock
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance. Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics. Chlorpromazine and amitriptyline have been show
Externí odkaz:
https://doaj.org/article/c0b86e8c528248f1b64fee868c1d93ae
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Group D and group B Salmonella enterica serovars differ in their susceptibility to colistin with the former frequently intrinsically resistant (MIC > 2 μg/ml); however, the mechanism has not been described. Here, we show that the O-antigen
Externí odkaz:
https://doaj.org/article/a5408f768a5543cfb08dcda81aaf3e3b
Autor:
Michelle M. C. Buckner, M. Laura Ciusa, Richard W. Meek, Alice R. Moorey, Gregory E. McCallum, Emma L. Prentice, Jeremy P. Reid, Luke J. Alderwick, Alessandro Di Maio, Laura J. V. Piddock
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Antimicrobial-resistant (AMR) infections pose a serious risk to human and animal health. A major factor contributing to this global crisis is the sharing of resistance genes between different bacteria via plasmids. The WHO lists Enterobacter
Externí odkaz:
https://doaj.org/article/877cafc750ec47c2b401c0945918e09f