Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Laura J Klesse"'
Autor:
Jingwei Huang, Donghan M. Yang, Ruichen Rong, Kuroush Nezafati, Colin Treager, Zhikai Chi, Shidan Wang, Xian Cheng, Yujia Guo, Laura J. Klesse, Guanghua Xiao, Eric D. Peterson, Xiaowei Zhan, Yang Xie
Publikováno v:
npj Digital Medicine, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Existing natural language processing (NLP) methods to convert free-text clinical notes into structured data often require problem-specific annotations and model training. This study aims to evaluate ChatGPT’s capacity to extract informatio
Externí odkaz:
https://doaj.org/article/e549ab435ab1449ba0936dca3ae52846
Autor:
Funan He, Abhik M. Bandyopadhyay, Laura J. Klesse, Anna Rogojina, Sang H. Chun, Erin Butler, Taylor Hartshorne, Trevor Holland, Dawn Garcia, Korri Weldon, Luz-Nereida Perez Prado, Anne-Marie Langevin, Allison C. Grimes, Aaron Sugalski, Shafqat Shah, Chatchawin Assanasen, Zhao Lai, Yi Zou, Dias Kurmashev, Lin Xu, Yang Xie, Yidong Chen, Xiaojing Wang, Gail E. Tomlinson, Stephen X. Skapek, Peter J. Houghton, Raushan T. Kurmasheva, Siyuan Zheng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Subcutaneous patient-derived xenografts (PDXs) are an important tool for childhood cancer research. Here, we describe a resource of 68 early passage PDXs established from 65 pediatric solid tumor patients. Through genomic profiling of paired
Externí odkaz:
https://doaj.org/article/7acada1d5c1a4ea691eda4a7f049f2e0
Autor:
Anna Rogojina, Laura J. Klesse, Erin Butler, Jiwoong Kim, He Zhang, Xue Xiao, Lei Guo, Qinbo Zhou, Taylor Hartshorne, Dawn Garcia, Korri Weldon, Trevor Holland, Abhik Bandyopadhyay, Luz Perez Prado, Shidan Wang, Donghan M. Yang, Anne-Marie Langevan, Yi Zou, Allison C. Grimes, Chatchawin Assanasen, Vinod Gidvani-Diaz, Siyuan Zheng, Zhao Lai, Yidong Chen, Yang Xie, Gail E. Tomlinson, Stephen X. Skapek, Raushan T. Kurmasheva, Peter J. Houghton, Lin Xu
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108171- (2023)
Summary: Patient-derived xenografts (PDX) remain valuable models for understanding the biology and for developing novel therapeutics. To expand current PDX models of childhood leukemia, we have developed new PDX models from Hispanic patients, a subgr
Externí odkaz:
https://doaj.org/article/22cacf03f3b04f17bc8080bce501067f
Autor:
Ferzana A. Hossain, BS, Hector J. Marquez, MD, Daniel L. Veltkamp, MD, Sophia Q. Xie, MD, Laura J. Klesse, MD, PhD, Charles F. Timmons, MD, PhD, Cory M. Pfeifer, MD, MS
Publikováno v:
Radiology Case Reports, Vol 15, Iss 3, Pp 186-189 (2020)
Leptomeningeal melanocytosis is a rare cause of seizure in the pediatric population. Shown here is a case of this disease in a 9-year-old male who presented with seizures and minor trauma. Imaging showed progression of leptomeningeal enhancement in t
Externí odkaz:
https://doaj.org/article/915a0b41f83b45468db0dd62457dc314
Publikováno v:
JID Innovations, Vol 1, Iss 3, Pp 100044- (2021)
Neurofibromatosis type 1 (NF1) is one of the most common neurocutaneous genetic disorders, presenting with different cutaneous features such as café-au-lait macules, intertriginous skin freckling, and neurofibromas. Although most of the disease mani
Externí odkaz:
https://doaj.org/article/1be544bfce7040a89934faf5cdaf43df
Autor:
Peter M K de Blank, Andrea M Gross, Srivandana Akshintala, Jaishri O Blakeley, Gideon Bollag, Ashley Cannon, Eva Dombi, Jason Fangusaro, Bruce D Gelb, Darren Hargrave, AeRang Kim, Laura J Klesse, Mignon Loh, Staci Martin, Christopher Moertel, Roger Packer, Jonathan M Payne, Katherine A Rauen, Jonathan J Rios, Nathan Robison, Elizabeth K Schorry, Kevin Shannon, David A Stevenson, Elliot Stieglitz, Nicole J Ullrich, Karin S Walsh, Brian D Weiss, Pamela L Wolters, Kaleb Yohay, Marielle E Yohe, Brigitte C Widemann, Michael J Fisher
Publikováno v:
Neuro Oncol
Neuro-Oncology, vol 24, iss 11
Neuro-Oncology, vol 24, iss 11
The wide variety of clinical manifestations of the genetic syndrome neurofibromatosis type 1 (NF1) are driven by overactivation of the RAS pathway. Mitogen-activated protein kinase kinase inhibitors (MEKi) block downstream targets of RAS. The recent
Autor:
Peter L. Stavinoha, Cody Solesbee, Susan M. Swearer, Steven Svoboda, Laura J. Klesse, Alice Ann Holland
Publikováno v:
Children, Vol 8, Iss 2, p 145 (2021)
Neurofibromatosis type 1 (NF1) is an autosomal disorder associated with numerous physical stigmata. Children with NF1 are at known risk for attention-deficit/hyperactivity disorder (ADHD), academic struggles, and significant social difficulties and a
Externí odkaz:
https://doaj.org/article/c4e25d7486714707adf9db53dcff26d4
Autor:
Daniel C Bowers, Veena Rajaram, Matthias A Karajannis, Sharon L Gardner, Jack Meng-Fen Su, Patricia Baxter, Sonia Partap, Laura J Klesse
Publikováno v:
Neuro-Oncology Advances. 5
BackgroundPreclinical studies have suggested that mTOR pathway signaling may be a potential therapeutic target for childhood ependymoma.MethodsA phase II clinical trial (ClinicalTrials.gov identifier: NCT02155920) of single-agent everolimus was perfo
Autor:
Alyx B. Porter, Macarena I. de la Fuente, Sadhana Jackson, Erin M. Dunbar, Ekokobe Fonkem, Akanksha Sharma, Terri S. Armstrong, Na Tosha Gatson, Shawn L. Hervey-Jumper, Elizabeth Vera, Laura J. Klesse, Yazmin Odia, Alvina Acquaye, Alissa A. Thomas, Ugonma Chukwueke, Sandra Camelo-Piragua, Tamra E. Werbowetski-Ogilvie
Publikováno v:
Neuro Oncol
Background Neuro-oncology has grown tremendously since 2010, marked by increasing society membership, specialized clinical expertise, and new journals. Yet, modest improvement in racial/ethnic diversity amongst clinical trial participants, researcher
Autor:
Jineta Banerjee, Jan M. Friedman, Laura J. Klesse, Kaleb H. Yohay, Justin T. Jordan, Scott R. Plotkin, Robert J. Allaway, Jaishri O. Blakeley
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics.
People with pre-existing conditions may be more susceptible to severe COVID-19 when infected by SARS-CoV-2. The relative risk and severity of SARS-CoV-2 infection in people with rare diseases such as neurofibromatosis type 1 (NF1), neurofibromatosis