Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Laura J H Milgram"'
Autor:
Mary E. Teresi, Mark R. Weatherly, Kathleen A. Hilliard, Janice L. Launspach, Richard C. Ahrens, Moira L. Aitken, Nael A. McCarty, Warren E. Regelmann, Michael W. Konstan, Thomas A. Standaert, Cynthia Tuthill, Thomas J. Kelley, Laura J H Milgram
Publikováno v:
Pediatric Pulmonology. 33:90-98
CPX (8-cyclopentyl-1,3-dipropylxanthine) is a novel compound currently under development as a potential treatment for cystic fibrosis (CF). The drug has been shown to increase chloride efflux and CFTR trafficking in vitro in CF airway cells. This pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12130711e73722ebdaa259e39458813f
https://doi.org/10.1002/ppul.10041
https://doi.org/10.1002/ppul.10041
Autor:
Kathleen A. Hilliard, Moira L. Aitken, Michael W. Konstan, Mary E. Teresi, Mark R. Weatherly, Richard C. Ahrens, Thomas A. Standaert, Laura J H Milgram, Thomas J. Kelley, Nael A. McCarty, Janice L. Launspach, Seung-Ho Han
Publikováno v:
Pediatric Pulmonology. 33:142-150
One of the goals of current research in cystic fibrosis (CF) is to develop treatments that correct or compensate for defects in function of the cystic fibrosis transmembrane regulator (CFTR) gene. The use of outcome measures that assess CFTR function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c73f89b764845ad020ff4e09f1e4215
https://doi.org/10.1002/ppul.10043
https://doi.org/10.1002/ppul.10043
Autor:
Laura J H Milgram
Publikováno v:
Annals of the American Thoracic Society. 11(6)
The United States Food and Drug Administration recently considered a policy to transfer inhaled short-acting bronchodilators to over-the-counter status if conditions of safe use can be established. The American Thoracic Society filed a comment in opp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f08de8493fb5ddeaec0117ee445422e
https://pubmed.ncbi.nlm.nih.gov/24964175
https://pubmed.ncbi.nlm.nih.gov/24964175
Publikováno v:
Proceedings of the National Academy of Sciences. 94:2604-2608
The gene causing cystic fibrosis (CF) encodes the CF transmembrane conductance regulator (CFTR), a cAMP-regulated chloride channel. Mutations in this gene result in reduced transepithelial chloride permeability across tissues affected in CF. Conseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46209874b05a38f89961cd5db265b180
https://doi.org/10.1073/pnas.94.6.2604
https://doi.org/10.1073/pnas.94.6.2604
Autor:
Lisa LaVange, Jean M. Engels, Bruce C. Marshall, Amy E. Schaberg, George Z. Retsch-Bogart, Bonnie W. Ramsey, Cori L. Daines, Judy Williams, Jo Ann Gorden, Pamela L. Zeitlin, Carlos Milla, Ronald L. Gibson, Dave Mathews, Robin R. Deterding, Laura J H Milgram
Publikováno v:
Pediatric pulmonology. 39(4)
Denufosol tetrasodium (INS37217) is a selective P2Y(2) agonist that stimulates ciliary beat frequency and Cl(-) secretion in normal and cystic fibrosis (CF) airway epithelia, and is being investigated as an inhaled treatment for CF. The Cl(-) secreto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b761bd07a9f1ccb0fa9a33cc50bf77a2
https://pubmed.ncbi.nlm.nih.gov/15704203
https://pubmed.ncbi.nlm.nih.gov/15704203
Autor:
Carla Foy, Peadar G. Noone, Pierre Yves Berclaz, Michael W. Konstan, Louis J. Boitano, Julia Emerson, Thomas A. Standaert, Michael R Knowles, Keith Hammond, Lois Brass, Pamela L. Zeitlin, Zoe Davies, Laura J H Milgram, Janice Hunter
Publikováno v:
Pediatric pulmonology. 37(5)
Patients with cystic fibrosis (CF) can be discriminated from healthy subjects by measurement of the nasal potential difference, which has become a useful outcome measure for therapies directed toward correcting defective electrolyte transport in CF.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a57a21f070ccca364709c19661e3424
https://pubmed.ncbi.nlm.nih.gov/15095320
https://pubmed.ncbi.nlm.nih.gov/15095320
A multicenter study of the effect of solution temperature on nasal potential difference measurements
Autor:
Carla Foy, Michael P. Boyle, Michael R. Knowles, Thomas A. Standaert, Laura J H Milgram, Marie Diener-West, Pamela L. Zeitlin
Publikováno v:
Chest. 124(2)
Nasal potential difference (PD) measurement quantifies the abnormal sodium and chloride transport that is characteristic of cystic fibrosis (CF) and has gained acceptance as both a diagnostic tool and outcome measure for new CF therapies. Because sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c077c26648ddf57618c2dc2ff19d1985
https://pubmed.ncbi.nlm.nih.gov/12907532
https://pubmed.ncbi.nlm.nih.gov/12907532
Autor:
Don Kellerman, Peadar G. Noone, Ronald L. Gibson, Pamela L. Zeitlin, W. Craig Johnson, Jean Mundahl, David M. Rodman, Bonnie W. Ramsey, Moira L. Aitken, Michael P. Boyle, Michael W. Konstan, Laura J H Milgram, Judy Williams-Warren, Mark Dovey, George Retsch-Bogort, Robert W. Wilmott, Nicole Hamblett, Frank J. Accurso
Publikováno v:
Pediatric pulmonology. 32(2)
Cystic fibrosis (CF) is characterized by defective cystic fibrosis transmembrane regulator (CFTR) expression and function, associated with abnormal ion transport and mucociliary clearance, and clinical lung disease. Triphosphate nucleotides such as u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5661cbdffcd73aa67543eddb91dc6c
https://pubmed.ncbi.nlm.nih.gov/11477729
https://pubmed.ncbi.nlm.nih.gov/11477729
Autor:
Jennifer M. Payne, Osman Muhammad, Mark J. Cooper, Tomasz Kowalczyk, Robert C. Moen, Assem G. Ziady, Pamela B. Davis, Michael W. Konstan, Kathleen A. Hilliard, Susannah L. Hyatt, Jeffrey S. Wagener, Laura J H Milgram, Tamara L. Fink, Christopher R. Gedeon, Sharon M. Oette, Robert C. Stern
Publikováno v:
Human Gene Therapy. :041210060115001
A double-blind, dose escalation gene transfer trial was conducted in subjects with cystic fibrosis (CF), among whom placebo (saline) or compacted DNA was superfused onto the inferior turbinate of the right or left nostril. The vector consisted of sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163da19c488ae8dc47dc63065166475f
https://doi.org/10.1089/hum.2004.15.ft-2
https://doi.org/10.1089/hum.2004.15.ft-2