Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Laura J Corbin"'
Autor:
Naveed Sattar, Kaitlin H Wade, Dimitri J Pournaras, Nicholas J Timpson, Madeleine L Smith, Lucy J Goudswaard, Laura J Corbin
Publikováno v:
BMJ Medicine, Vol 3, Iss 1 (2024)
Associations between obesity and health are unequivocal and coupled with a substantial body of evidence suggesting that associations are likely causal. These associations and the supporting causal evidence are useful, but hide both the inadequacies o
Externí odkaz:
https://doaj.org/article/545b6bc4f080412296f2f3e270f12e00
Autor:
Kaitlin H Wade, Si Fang, Nicholas J Timpson, Laura J Corbin, Nancy McBride, Thomas Battram, Matthew A Lee, Charlie Hatcher, Wenxin Wan, Luke A McGuinness
Publikováno v:
Wellcome Open Research, Vol 7 (2023)
Mendelian randomization (MR) is increasingly used for generating estimates of the causal impact of exposures on outcomes. Evidence suggests a causal role of excess adipose tissue (adiposity) on many health outcomes. However, this body of work has not
Externí odkaz:
https://doaj.org/article/00574839a43c4f4087f8c36434469457
Autor:
Florence Guida, Vanessa Y Tan, Laura J Corbin, Karl Smith-Byrne, Karine Alcala, Claudia Langenberg, Isobel D Stewart, Adam S Butterworth, Praveen Surendran, David Achaintre, Jerzy Adamski, Pilar Amiano, Manuela M Bergmann, Caroline J Bull, Christina C Dahm, Audrey Gicquiau, Graham G Giles, Marc J Gunter, Toomas Haller, Arnulf Langhammer, Tricia L Larose, Börje Ljungberg, Andres Metspalu, Roger L Milne, David C Muller, Therese H Nøst, Elin Pettersen Sørgjerd, Cornelia Prehn, Elio Riboli, Sabina Rinaldi, Joseph A Rothwell, Augustin Scalbert, Julie A Schmidt, Gianluca Severi, Sabina Sieri, Roel Vermeulen, Emma E Vincent, Melanie Waldenberger, Nicholas J Timpson, Mattias Johansson
Publikováno v:
PLoS Medicine, Vol 18, Iss 9, p e1003786 (2021)
BackgroundExcess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study, we sought to identify circulat
Externí odkaz:
https://doaj.org/article/e11457db8ee54250ba74852b65231bb7
Autor:
Fernando Riveros-McKay, Vanisha Mistry, Rebecca Bounds, Audrey Hendricks, Julia M Keogh, Hannah Thomas, Elana Henning, Laura J Corbin, Understanding Society Scientific Group, Stephen O'Rahilly, Eleftheria Zeggini, Eleanor Wheeler, Inês Barroso, I Sadaf Farooqi
Publikováno v:
PLoS Genetics, Vol 15, Iss 1, p e1007603 (2019)
The variation in weight within a shared environment is largely attributable to genetic factors. Whilst many genes/loci confer susceptibility to obesity, little is known about the genetic architecture of healthy thinness. Here, we characterise the her
Externí odkaz:
https://doaj.org/article/1f09bb21172049b28970beeed6bbd21e
Autor:
K. Alaine Broadaway, Xianyong Yin, Alice Williamson, Victoria A. Parsons, Emma P. Wilson, Anne H. Moxley, Swarooparani Vadlamudi, Arushi Varshney, Anne U. Jackson, Vasudha Ahuja, Stefan R. Bornstein, Laura J. Corbin, Graciela E. Delgado, Om P. Dwivedi, Lilian Fernandes Silva, Timothy M. Frayling, Harald Grallert, Stefan Gustafsson, Liisa Hakaste, Ulf Hammar, Christian Herder, Sandra Herrmann, Kurt Højlund, David A. Hughes, Marcus E. Kleber, Cecilia M. Lindgren, Ching-Ti Liu, Jian’an Luan, Anni Malmberg, Angela P. Moissl, Andrew P. Morris, Nikolaos Perakakis, Annette Peters, John R. Petrie, Michael Roden, Peter E.H. Schwarz, Sapna Sharma, Angela Silveira, Rona J. Strawbridge, Tiinamaija Tuomi, Andrew R. Wood, Peitao Wu, Björn Zethelius, Damiano Baldassarre, Johan G. Eriksson, Tove Fall, Jose C. Florez, Andreas Fritsche, Bruna Gigante, Anders Hamsten, Eero Kajantie, Markku Laakso, Jari Lahti, Deborah A. Lawlor, Lars Lind, Winfried März, James B. Meigs, Johan Sundström, Nicholas J. Timpson, Robert Wagner, Mark Walker, Nicholas J. Wareham, Hugh Watkins, Inês Barroso, Stephen O’Rahilly, Niels Grarup, Stephen CJ. Parker, Michael Boehnke, Claudia Langenberg, Eleanor Wheeler, Karen L. Mohlke
Publikováno v:
et al. 2023, ' Loci for insulin processing and secretion provide insight into type 2 diabetes risk ', American Journal of Human Genetics, vol. 110, no. 2, pp. 284-299 . https://doi.org/10.1016/j.ajhg.2023.01.002
Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin secretory capacity in the setting of insulin resistance. W
Autor:
Matthew A Lee, Charlie Hatcher, Luke A McGuinness, Nancy McBride, Thomas Battram, Wenxin Wan, Si Fang, Kaitlin H Wade, Laura J Corbin, Nicholas J Timpson
Publikováno v:
Lee, M, Hatcher, C A, McGuinness, L, Mcbride, N S, Battram, T M, Wan, W, Fang, S, Wade, K H, Corbin, L J & Timpson, N J 2022, ' Systematic review and meta-analyses : What has the application of Mendelian randomization told us about the causal effect of adiposity on health outcomes? ', Wellcome Open Research, vol. 7, no. 308 . https://doi.org/10.12688/wellcomeopenres.18657.1
Mendelian randomization (MR) is increasingly used for generating estimates of the causal impact of exposures on outcomes. Evidence suggests a causal role of excess adipose tissue (adiposity) on many health outcomes. However, this body of work has not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c56f91827c946bab7323a74975db48
https://research-information.bris.ac.uk/en/publications/2ea7a686-d396-484e-88b4-a3d47e13f0ed
https://research-information.bris.ac.uk/en/publications/2ea7a686-d396-484e-88b4-a3d47e13f0ed
Autor:
Neil J. Goulding, Lucy J. Goudswaard, David A. Hughes, Laura J. Corbin, Alix Groom, Susan Ring, Nicholas J. Timpson, Abigail Fraser, Kate Northstone, Matthew Suderman
Publikováno v:
Goulding, N J, Goudswaard, L, Hughes, D A, Corbin, L J, Groom, A, Ring, S M, Timpson, N J, Fraser, A, Northstone, K & Suderman, M J 2022, ' Inflammation proteomics datasets in the ALSPAC cohort ', Wellcome Open Research . https://doi.org/10.12688/wellcomeopenres.18482.1
Proteomics is the identification, detection and quantification of proteins within a biological sample. The complete set of proteins expressed by an organism is known as the proteome. The availability of new high-throughput proteomic technologies, suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62c53a38217e35b3d563c9c23c8fe54
https://research-information.bris.ac.uk/en/publications/0d7b2861-a741-42ef-bf7c-ae1216147019
https://research-information.bris.ac.uk/en/publications/0d7b2861-a741-42ef-bf7c-ae1216147019
Autor:
Laura J. Corbin, Jessica Pope, Jacqueline Sanson, Douglas F. Antczak, Donald Miller, Raheleh Sadeghi, Samantha A. Brooks
Publikováno v:
Genes, Vol 11, Iss 6, p 606 (2020)
Novel coat colour phenotypes often emerge during domestication, and there is strong evidence of genetic selection for the two main genes that control base coat colour in horses—ASIP and MC1R. These genes direct the type of pigment produced, red phe
Externí odkaz:
https://doaj.org/article/e6eb140425514397a9061ac8ea72c7f6
Autor:
Lucy J. Goudswaard, Laura J. Corbin, Kate L. Burley, Andrew Mumford, Parsa Akbari, Nicole Soranzo, Adam S. Butterworth, Nicholas A. Watkins, Dimitri J. Pournaras, Jessica Harris, Nicholas J. Timpson, Ingeborg Hers
Publikováno v:
Goudswaard, L J, Corbin, L J, Burley, K L, Mumford, A, Akbari, P, Soranzo, N, Butterworth, A S, Watkins, N A, Pournaras, D J, Harris, J, Timpson, N J & Hers, I 2022, ' Higher body mass index raises immature platelet count : potential contribution to obesity-related thrombosis ', Platelets, vol. 33, no. 6, pp. 869-878 . https://doi.org/10.1080/09537104.2021.2003317
Higher body mass index (BMI) is a risk factor for thrombosis. Platelets are essential for hemostasis but contribute to thrombosis when activated pathologically. We hypothesized that higher BMI leads to changes in platelet characteristics, thereby inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::984f78e877db1b5adb10fd5c506f292a
https://www.repository.cam.ac.uk/handle/1810/332820
https://www.repository.cam.ac.uk/handle/1810/332820
Autor:
Laura J. Corbin, David A. Hughes, Caroline J. Bull, Emma E. Vincent, Madeleine L. Smith, Alex McConnachie, Claudia-Martina Messow, Paul Welsh, Roy Taylor, Michael E. J. Lean, Naveed Sattar, Nicholas J. Timpson
Use of high-throughput metabolomics technologies in a variety of study designs has demonstrated a strong and consistent metabolomic signature of overweight and type 2 diabetes. However, the extent to which these metabolomic patterns can be recovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac6bb1b3b9414984878a5d87e4405ca1
https://doi.org/10.1101/2022.07.15.22277671
https://doi.org/10.1101/2022.07.15.22277671