Zobrazeno 1 - 10 of 30 pro vyhledávání: '"Laura J Cobb"'
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Akademický článek
Humanin: a novel central regulator of peripheral insulin action.
Autor: Radhika H Muzumdar, Derek M Huffman, Gil Atzmon, Christoph Buettner, Laura J Cobb, Sigal Fishman, Temuri Budagov, Lingguang Cui, Francine H Einstein, Aruna Poduval, David Hwang, Nir Barzilai, Pinchas Cohen
Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6334 (2009)
Decline in insulin action is a metabolic feature of aging and is involved in the development of age-related diseases including Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD). A novel mitochondria-associated peptide, Humanin (HN), has a
Externí odkaz: https://doaj.org/article/3f99404b30f64a889176582ce9cc202c
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Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers
Autor: Carmel Ashur, Derek M. Huffman, Richard G. Wong, Radhika Muzumdar, Pinchas Cohen, Jialin Xiao, Hemal H. Mehta, Nir Barzilai, Laura J. Cobb, Junxiang Wan, Hiromi Nakamura, Changhan Lee, Qinglei Gao, Kelvin Yen
Publikováno v: Aging (Albany NY)
Mitochondria are key players in aging and in the pathogenesis of age-related diseases. Recent mitochondrial transcriptome analyses revealed the existence of multiple small mRNAs transcribed from mitochondrial DNA (mtDNA). Humanin (HN), a peptide enco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8166bf9f9d477694d76ba03a3adf3061
https://doi.org/10.18632/aging.100943
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6
The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis
Autor: Ronald S. Swerdloff, Yue Jia, Laura J. Cobb, Christina Wang, Kuk-Wha Lee, Pinchas Cohen, Yanhe Lue
Publikováno v: Andrology. 1:651-659
Summary We have previously demonstrated that the mitochondria-derived cytoprotective peptide humanin (HN), when administered intratesticularly to rats, rescues germ cells from apoptosis secondary to testicular stress of hormonal deprivation induced b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c827ad3f768a3a2e43dc5cfc68a230
https://doi.org/10.1111/j.2047-2927.2013.00091.x
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7
Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress
Autor: Yun K. Oh, Amir Lerman, Richard E. Pagano, Andreas S. Schroeder, Laura J. Cobb, Pinchas Cohen, Lilach O. Lerman, Adi R. Bachar, Lea Scheffer, Hiromi Nakamura
Publikováno v: Cardiovascular Research. 88:360-366
Humanin (HN) is a 24-amino acid peptide that has been shown to have an anti-apoptotic function against neuronal cell death caused by Alzheimer's disease. Increased oxidative stress, one of the major factors contributing to this cell death, also plays
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6f2c8b907bb8512649845649379214
https://doi.org/10.1093/cvr/cvq191
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The neurosurvival factor Humanin inhibits β-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice
Autor: Valdislava Paharkova-Vatchkova, Michael Hakimi, Kuk-Wha Lee, Laura J. Cobb, Pinchas Cohen, Patricia Park, Phuong T. Hoang
Publikováno v: Metabolism. 59:343-349
Pancreatic beta-cell apoptosis is important in the pathogenesis and potential treatment of type 1 diabetes mellitus. We investigated whether Humanin, a recently described survival factor for neurons, could improve the survival of beta-cells and delay
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65c353f51d418c21d49f0ccdd3d9eac
https://doi.org/10.1016/j.metabol.2009.08.001
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IGF‐independent effects of insulin‐like growth factor binding protein‐5 (Igfbp5) in vivo
Autor: Laura J. Cobb, Dervis A. Salih, Gyanendra Tripathi, Anja C. Drozd, Ruth A. Cosgrove, Jennifer M. Pell
Publikováno v: The FASEB Journal. 23:2616-2626
IGF activity is regulated tightly by a family of IGF binding proteins (IGFBPs). IGFBP-5 is the most conserved of these and is up-regulated significantly during differentiation of several key lineages and in some cancers. The function of IGFBP-5 in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18059dd8c98c655192468f184436d57f
https://doi.org/10.1096/fj.08-114124
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Phosphorylation by DNA-Dependent Protein Kinase Is Critical for Apoptosis Induction by Insulin-Like Growth Factor Binding Protein-3
Autor: Laura J. Cobb, Pinchas Cohen, Kuk-Wha Lee, Bingrong Liu
Publikováno v: Cancer Research. 66:10878-10884
Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) promotes apoptosis of cancer cells by both IGF-dependent and IGF-independent mechanisms. In vitro phosphorylation of IGFBP-3 by DNA-dependent protein kinase (DNA-PK) has been reported but w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813e17e4603071e5f3871bee33a7055c
https://doi.org/10.1158/0008-5472.can-06-0585
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