Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Laura J Byrnes"'
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51628 (2012)
Endocytosis is a fundamental process in signaling and membrane trafficking. The formation of vesicles at the plasma membrane is mediated by the G protein dynamin that catalyzes the final fission step, the actin cytoskeleton, and proteins that sense o
Externí odkaz:
https://doaj.org/article/37eea684699b4e77b6e482680a75cb2b
Autor:
Qi Wang, Laura J Byrnes, Bo Shui, Ute F Röhrig, Avtar Singh, Dmitriy M Chudakov, Sergey Lukyanov, Warren R Zipfel, Michael I Kotlikoff, Holger Sondermann
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23513 (2011)
Fluorescent proteins that can switch between distinct colors have contributed significantly to modern biomedical imaging technologies and molecular cell biology. Here we report the identification and biochemical analysis of a green-shifted red fluore
Externí odkaz:
https://doaj.org/article/eaf6abd054c74006af0981c4e88e0a13
Autor:
Bo Shui, Qi Wang, Frank Lee, Laura J Byrnes, Dmitry M Chudakov, Sergey A Lukyanov, Holger Sondermann, Michael I Kotlikoff
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20505 (2011)
Circular permutation of fluorescent proteins provides a substrate for the design of molecular sensors. Here we describe a systematic exploration of permutation sites for mCherry and mKate using a tandem fusion template approach. Circular permutants r
Externí odkaz:
https://doaj.org/article/45cf4ea31123419a808dec7e166a6924
Autor:
Allyn T. Londregan, Karlygash Aitmakhanova, James Bennett, Laura J. Byrnes, Daniel P. Canterbury, Xiayun Cheng, Thomas Christott, Jennifer Clemens, Steven B. Coffey, João M. Dias, Matthew S. Dowling, Gillian Farnie, Oleg Fedorov, Kimberly F. Fennell, Vicki Gamble, Carina Gileadi, Charline Giroud, Michael R. Harris, Brett D. Hollingshead, Kilian Huber, Magdalena Korczynska, Kimberly Lapham, Paula M. Loria, Arjun Narayanan, Dafydd R. Owen, Brigitt Raux, Parag V. Sahasrabudhe, Roger B. Ruggeri, Laura Díaz Sáez, Ingrid A. Stock, Benjamin A. Thuma, Andy Tsai, Alison E. Varghese
Publikováno v:
Journal of medicinal chemistry.
A series of small-molecule YEATS4 binders have been discovered as part of an ongoing research effort to generate high-quality probe molecules for emerging and/or challenging epigenetic targets. Analogues such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f200505c5effa14e470509072c0e10b
https://pubmed.ncbi.nlm.nih.gov/36562986
https://pubmed.ncbi.nlm.nih.gov/36562986
Publikováno v:
The Journal of cell biology. 220(11)
Atlastin (ATL) GTPases catalyze homotypic membrane fusion of the peripheral endoplasmic reticulum (ER). GTP-hydrolysis–driven conformational changes and membrane tethering are prerequisites for proper membrane fusion. However, the molecular basis f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df8ba557daafec9f4be0831573da0bc
https://pubmed.ncbi.nlm.nih.gov/34546351
https://pubmed.ncbi.nlm.nih.gov/34546351
Autor:
Kathleen A. Farley, Parag Sahasrabudhe, Manjinder S. Lall, Justin Bellenger, Bruce Allen Lefker, Xidong Feng, Timothy L. Foley, Scott L. Hultgren, Dominik K. Kölmel, Jinqiao Wan, Bo Liu, Justin I. Montgomery, Anokha S. Ratnayake, Mark Edward Flanagan, Shi Chen, Laura J. Byrnes, Andre Shavnya, Tim F. Ryder
Publikováno v:
Bioorganicmedicinal chemistry. 41
The ability to predict chemical structure from DNA sequence has to date been a necessary cornerstone of DNA-encoded library technology. DNA-encoded libraries (DELs) are typically screened by immobilized affinity selection and enriched library members
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb276460d12574fb80ff34a159c182eb
https://pubmed.ncbi.nlm.nih.gov/34000509
https://pubmed.ncbi.nlm.nih.gov/34000509
Autor:
Amy Brault, Leslie Anthony Dakin, Fabien Vincent, Reto Horst, James F. Smith, John I. Trujillo, Darren Dumlao, Laura J. Byrnes, Daniel C. Schmitt, Suman Shanker, Justin Hall, Ann Aulabaugh, Jimson Wong, Matt Griffor, Hong Wang, Erik C. Ralph
Publikováno v:
Protein Science. 26:2367-2380
Cyclic GMP-AMP synthase (cGAS) is activated by ds-DNA binding to produce the secondary messenger 2ʹ,3ʹ-cGAMP. cGAS is an important control point in the innate immune response; dysregulation of the cGAS pathway is linked to autoimmune diseases while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e36cd1b5d0dd1efa348020467a71b031
https://doi.org/10.1002/pro.3304
https://doi.org/10.1002/pro.3304
Autor:
Suman Shanker, Ann Aulabaugh, Kelong Wang, Julie D. Forman-Kay, P. Andrew Chong, Justin Hall, Ivan Viktorovich Efremov, Laura J. Byrnes, Hong Wang
Publikováno v:
Protein Science. 25:360-373
The most common mutation in cystic fibrosis (CF) patients is deletion of F508 (ΔF508) in the first nucleotide binding domain (NBD1) of the CF transmembrane conductance regulator (CFTR). ΔF508 causes a decrease in the trafficking of CFTR to the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709be8f9a4b25b001a4ef7ed86c744f0
https://doi.org/10.1002/pro.2821
https://doi.org/10.1002/pro.2821
Publikováno v:
The Journal of biological chemistry. 293(2)
The dynamin-related GTPase atlastin (ATL) catalyzes membrane fusion of the endoplasmic reticulum and thus establishes a network of branched membrane tubules. When ATL function is compromised, the morphology of the endoplasmic reticulum deteriorates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6b2b5a298c1f958f802b4a7961ebd0
https://pubmed.ncbi.nlm.nih.gov/29180453
https://pubmed.ncbi.nlm.nih.gov/29180453
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Cystic Fibrosis (CF) is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Mutations associated with CF cause loss-of-function in CFTR leading to salt imbalance in epithelial tissues. Kalydeco (also called VX-770 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c7ecd8e77278399a8ef819fa6c5dde
https://pubmed.ncbi.nlm.nih.gov/29549268
https://pubmed.ncbi.nlm.nih.gov/29549268