Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Laura J Blair"'
Autor:
Jeremy D Baker, Lindsey B Shelton, Dali Zheng, Filippo Favretto, Bryce A Nordhues, April Darling, Leia E Sullivan, Zheying Sun, Parth K Solanki, Mackenzie D Martin, Amirthaa Suntharalingam, Jonathan J Sabbagh, Stefan Becker, Eckhard Mandelkow, Vladimir N Uversky, Markus Zweckstetter, Chad A Dickey, John Koren, Laura J Blair
Publikováno v:
PLoS Biology, Vol 15, Iss 6, p e2001336 (2017)
The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is a primary pathology in
Externí odkaz:
https://doaj.org/article/b8e1004e37a14f80868d70e4b48f50e7
Autor:
Jonathan J Sabbagh, John C O'Leary, Laura J Blair, Torsten Klengel, Bryce A Nordhues, Sarah N Fontaine, Elisabeth B Binder, Chad A Dickey
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107241 (2014)
Single nucleotide polymorphisms (SNPs) in the FK506 binding protein 5 (FKBP5) gene combine with traumatic events to increase risk for post-traumatic stress and major depressive disorders (PTSD and MDD). These SNPs increase FKBP51 protein expression t
Externí odkaz:
https://doaj.org/article/8527db9aea6c4a06909d79dfa8141422
Autor:
John Koren, Yoshinari Miyata, Janine Kiray, John C O'Leary, Lana Nguyen, Jianping Guo, Laura J Blair, Xiaokai Li, Umesh K Jinwal, Jin Q Cheng, Jason E Gestwicki, Chad A Dickey
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35566 (2012)
MKT-077, a rhodacyanine dye, was shown to produce cancer specific cell death. However, complications prevented the use of this compound beyond clinical trials. Here we describe YM-1, a derivative of MKT-077. We found that YM-1 was more cytotoxic and
Externí odkaz:
https://doaj.org/article/5a1f2f7e12414802a13741110362ebfe
Autor:
John C O'Leary, Sheetal Dharia, Laura J Blair, Sarah Brady, Amelia G Johnson, Melinda Peters, Joyce Cheung-Flynn, Marc B Cox, Gabriel de Erausquin, Edwin J Weeber, Umesh K Jinwal, Chad A Dickey
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24840 (2011)
The gene FKBP5 codes for FKBP51, a co-chaperone protein of the Hsp90 complex that increases with age. Through its association with Hsp90, FKBP51 regulates the glucocorticoid receptor (GR). Single nucleotide polymorphisms (SNPs) in the FKBP5 gene asso
Externí odkaz:
https://doaj.org/article/c5523d7959a047feb75cf7ab762184ef
Autor:
Rekha S. Patel, Ashley Lui, Charles Hudson, Lauren Moss, Robert P. Sparks, Shannon E. Hill, Yan Shi, Jianfeng Cai, Laura J. Blair, Paula C. Bickford, Niketa A. Patel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Shifts in normal aging set stage for neurodegeneration and dementia affecting 1 in 10 adults. The study demonstrates that lncRNA GAS5 is decreased in aged and Alzheimer’s disease brain. The role and targets of lncRNA GAS5 in the aging brai
Externí odkaz:
https://doaj.org/article/7e1cfc1749fc453bb56dae844a64cc03
Autor:
Ryan Green, Karthick Mayilsamy, Andrew R. McGill, Taylor E. Martinez, Bala Chandran, Laura J. Blair, Paula C. Bickford, Shyam S. Mohapatra, Subhra Mohapatra
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 217-229 (2022)
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000 infections globally thus far. Up to 30% of individuals with mild to severe disease develop long COVID, exhibiting diverse neurologic symptoms including dementias. However, t
Externí odkaz:
https://doaj.org/article/f5788a47b7924c8db7fe23ddaa442896
Autor:
Yanan Zhu, Lauren Gandy, Fuming Zhang, Jian Liu, Chunyu Wang, Laura J. Blair, Robert J. Linhardt, Lianchun Wang
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1792 (2022)
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis. Heparan sulfate proteoglycans,
Externí odkaz:
https://doaj.org/article/be7b1290ed8d49f9afda6cce318f64f8
Autor:
Shannon E. Hill, David Beaulieu-Abdelahad, Andrea Lemus, Jack M. Webster, Santiago Rodriguez Ospina, April L. Darling, Mackenzie D. Martin, Shreya Patel, Liznair Bridenstine, Ronald Swonger, Steven Paul, Roy Blackburn, Laurent Calcul, Chad A. Dickey, James W. Leahy, Laura J. Blair
Publikováno v:
ACS Chemical Biology. 18:1124-1135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6129a08167a81c8a896513b79849deb0
https://doi.org/10.1021/acschembio.2c00919
https://doi.org/10.1021/acschembio.2c00919
Publikováno v:
Journal of Cellular Biochemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aed834ab5e4e99fdf8fb7b0ea606ea30
https://doi.org/10.1002/jcb.30374
https://doi.org/10.1002/jcb.30374
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
The ATP-dependent 90 kDa heat shock protein, Hsp90, is a major regulator of protein triage, from assisting in nascent protein folding to refolding or degrading aberrant proteins. Tau, a microtubule associated protein, aberrantly accumulates in Alzhei
Externí odkaz:
https://doaj.org/article/8d0491ee745647938580bddead27f441