Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Laura J, Sharpe"'
Autor:
Lydia Qian, Nicola A. Scott, Isabelle M. Capell-Hattam, Eliza A. Draper, Nicole M. Fenton, Winnie Luu, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 5, Pp 100362- (2023)
Cholesterol biosynthesis is a highly regulated pathway, with over 20 enzymes controlled at the transcriptional and posttranslational levels. While some enzymes remain stable, increased sterol levels can trigger degradation of several synthesis enzyme
Externí odkaz:
https://doaj.org/article/c248162951394c64a07c42242ea8d86c
Autor:
Isabelle M. Capell-Hattam, Nicole M. Fenton, Hudson W. Coates, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 12, Pp 100295- (2022)
The enzymatic pathway of cholesterol biosynthesis has been well characterized. However, there remain several potential interacting proteins that may play ancillary roles in the regulation of cholesterol production. Here, we identified ERG28 (chromoso
Externí odkaz:
https://doaj.org/article/ed19bf38775a4237b40c5078c46e0707
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 4, Pp 888-897 (2015)
Cholesterol is essential to human health, and its levels are tightly regulated by a balance of synthesis, uptake, and efflux. Cholesterol synthesis requires the actions of more than twenty enzymes to reach the final product, through two alternate pat
Externí odkaz:
https://doaj.org/article/0edb925724c042fb831c75c0dae361c4
Autor:
Winnie Luu, Eser J. Zerenturk, Ika Kristiana, Martin P. Bucknall, Laura J. Sharpe, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 3, Pp 410-420 (2014)
The role of signaling in regulating cholesterol homeostasis is gradually becoming more widely recognized. Here, we explored how kinases and phosphorylation sites regulate the activity of the enzyme involved in the final step of cholesterol synthesis,
Externí odkaz:
https://doaj.org/article/0bc11d238d6a4d2ead8669b0473e7254
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1868:159266
Glucose metabolism and cholesterol synthesis are often regarded in isolation. Increasing evidence not only links these pathways but also suggests glucose catabolism regulates cholesterol synthesis. Uptake of glucose increases cholesterol production.
Autor:
Isabelle M. Capell-Hattam, Anika V. Prabhu, Andrew J. Brown, Lydia Qian, Gene Hart-Smith, Laura J. Sharpe
Publikováno v:
J Biol Chem
Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well-understood. However, of the ∼20 enzymes in cholesterol biosynthesis, post-tra
Autor:
Samuel J. Gullo, Nicola A. Scott, Winnie Luu, Andrew J. Brown, Isabelle M. Capell-Hattam, Laura J. Sharpe
Publikováno v:
Biochemical Journal
Cholesterol synthesis is a tightly controlled pathway, with over 20 enzymes involved. Each of these enzymes can be distinctly regulated, helping to fine-tune the production of cholesterol and its functional intermediates. Several enzymes are degraded
Autor:
Khosrow Adeli, Valentin Blanchard, Michael B. Boffa, Mikhail Bogdanov, Laura M. Bond, Andrew J. Brown, Hudson W. Coates, Paul A. Dawson, Fang Ding, William Dowhan, Guangwei Du, Sarah Farr, Eric A. Fisher, Gordon A. Francis, Anthony H. Futerman, Jessica M. Gullett, Joachim Herz, Victoria Higgins, Murray W. Huff, Elina Ikonen, Marlys L. Koschinsky, Kristina Kuhbandner, Richard Lehner, Sarah A. Lewis, Gary F. Lewis, Jun Liu, Zhaojin Liu, Andrea F. Lopez-Clavijo, Roger S. McLeod, Makoto Miyazaki, James M. Ntambi, Vesa M. Olkkonen, Lucas M. O'Neill, Theresa Pohlkamp, Ariel D. Quiroga, Katey J. Rayner, Marilyn D. Resh, Neale D. Ridgway, Charles O. Rock, Katherine M. Schmid, Laura J. Sharpe, Bebiana C. Sousa, Jennifer Taher, Jennifer K. Truong, Michael J.O. Wakelam, Changting Xiao, Hongyuan Yang, Dakai Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6f68922a76c48b2c267825a3a988e00
https://doi.org/10.1016/b978-0-12-824048-9.01002-6
https://doi.org/10.1016/b978-0-12-824048-9.01002-6
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1868:159237
Autor:
Ingrid C. Gelissen, Laura J. Sharpe, Cecilia Sandoval, Geetha Rao, Maaike Kockx, Leonard Kritharides, Wendy Jessup, Andrew J. Brown
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 10, Pp 2133-2140 (2012)
ABCG1 is an ABC half-transporter that exports cholesterol from cells to HDL. This study set out to investigate differences in posttranslational processing of two human ABCG1 protein isoforms, termed ABCG1(+12) and ABCG1(− 12), that differ by the pr
Externí odkaz:
https://doaj.org/article/c990d1183fe34e0abe873d41cfb2cd10