Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Laura J, Martins"'
Autor:
Albebson L. Lim, Philip Moos, Christopher D. Pond, Erica C. Larson, Laura J. Martins, Matthew A. Szaniawski, Vicente Planelles, Louis R. Barrows
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 386-413 (2022)
HIV-1 cDNA pre-integration complexes persist for weeks in macrophages and remain transcriptionally active. While previous work has focused on the transcription of HIV-1 genes; our understanding of the cellular milieu that accompanies viral production
Externí odkaz:
https://doaj.org/article/d117a10300674c17bc372d36e1db60f3
Autor:
Yue Zheng, Heidi L. Schubert, Parmit K. Singh, Laura J. Martins, Alan N. Engelman, Iván D’Orso, Christopher P. Hill, Vicente Planelles
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
CPSF6 is a cellular factor that regulates cleavage and polyadenylation of mRNAs and participates in HIV-1 infection by facilitating targeting of preintegration complexes to the chromatin. Our observations reveal a second role of CPSF6 in the HIV-1 li
Externí odkaz:
https://doaj.org/article/d7c36d3d4feb42ee994b4fd477199f64
Autor:
Laura J. Martins, Matthew A. Szaniawski, Elizabeth S. C. P. Williams, Mayte Coiras, Timothy M. Hanley, Vicente Planelles
Publikováno v:
Pathogens, Vol 11, Iss 2, p 163 (2022)
HIV-1 infection of myeloid cells is associated with the induction of an IFN response. How HIV-1 manipulates and subverts the IFN response is of key interest for the design of therapeutics to improve immune function and mitigate immune dysregulation i
Externí odkaz:
https://doaj.org/article/3d842d7222654701b250f160f66930eb
Autor:
Alberto Bosque, Kyle A. Nilson, Amanda B. Macedo, Adam M. Spivak, Nancie M. Archin, Ryan M. Van Wagoner, Laura J. Martins, Camille L. Novis, Matthew A. Szaniawski, Chris M. Ireland, David M. Margolis, David H. Price, Vicente Planelles
Publikováno v:
Cell Reports, Vol 18, Iss 5, Pp 1324-1334 (2017)
The presence of latent HIV-1 in infected individuals represents a major barrier preventing viral eradication. For that reason, reactivation of latent viruses in the presence of antiretroviral regimens has been proposed as a therapeutic strategy to ac
Externí odkaz:
https://doaj.org/article/92f594697d114cf5b8096f3da8d8641c
Publikováno v:
Journal of Leukocyte Biology. 112:1343-1356
Macrophages chronically infected with HIV-1 serve as a reservoir that contributes to HIV-1 persistence during antiretroviral therapy; however, the mechanisms governing the establishment and maintenance of this virus reservoir have not been fully eluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a11080b868626d3e38f1ab464e3bf1f
https://doi.org/10.1002/jlb.4ma0422-616r
https://doi.org/10.1002/jlb.4ma0422-616r
Autor:
Elizabeth S C P, Williams, Matthew A, Szaniawski, Laura J, Martins, Emily A, Innis, José, Alcamí, Timothy M, Hanley, Adam M, Spivak, Mayte, Coiras, Vicente, Planelles
Publikováno v:
Clin Res HIV AIDS
Macrophages are one of the main cellular targets of human immunodeficiency virus type 1 (HIV-1). Macrophage infection by HIV-1 is inefficient due to the presence of the viral restriction factor sterile alpha motif and histidine aspartic acid domain c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66e297d07817a26169fae86db30aa612
https://pubmed.ncbi.nlm.nih.gov/36589263
https://pubmed.ncbi.nlm.nih.gov/36589263
Autor:
Erica C Larson, Camille L Novis, Laura J Martins, Amanda B Macedo, Kadyn E Kimball, Alberto Bosque, Vicente Planelles, Louis R Barrows
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185162 (2017)
Following proviral integration into the host cell genome and establishment of a latent state, the human immunodeficiency virus type 1 (HIV-1) can reenter a productive life cycle in response to various stimuli. HIV-1 reactivation occurs when transcrip
Externí odkaz:
https://doaj.org/article/a2e8dc7a41ce4fd4a5543da80b0e0f14
Autor:
Cory H White, Bastiaan Moesker, Nadejda Beliakova-Bethell, Laura J Martins, Celsa A Spina, David M Margolis, Douglas D Richman, Vicente Planelles, Alberto Bosque, Christopher H Woelk
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1006026 (2016)
The search for an HIV-1 cure has been greatly hindered by the presence of a viral reservoir that persists despite antiretroviral therapy (ART). Studies of HIV-1 latency in vivo are also complicated by the low proportion of latently infected cells in
Externí odkaz:
https://doaj.org/article/97e20c946a3648c19d9550ee725d6bdf
Autor:
Albebson L. Lim, Christopher D. Pond, Laura J. Martins, Planelles, Erica C. Larson, Philip J. Moos, Louis R. Barrows, Matthew A. Szaniawski
HIV-1 cDNA pre-integration complexes have been shown to persist for weeks in macrophages and to be transcriptionally active. Early and late gene transcripts are produced, along with some viral proteins, yet whole virus is not. While previous work has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423e2bbe01f812074460f679a7a06482
https://doi.org/10.1101/2021.04.21.440655
https://doi.org/10.1101/2021.04.21.440655
Expression of HIV-1 accessory proteins Vif and Vpr results in G2/M cell cycle arrest by hijacking the host ubiquitin-proteasome system. Vif directs cell cycle arrest by targeting protein phosphatase 2, regulatory subunit B alpha (PP2AB56) for degrada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a3e3198555e8e5aa99bdb4c4daf079
https://doi.org/10.1101/2021.03.16.435666
https://doi.org/10.1101/2021.03.16.435666