Výsledky vyhledávání - "Laura J, Eccles"

Five-Year Survival Outcomes With Nivolumab Plus Ipilimumab Versus Chemotherapy as First-Line Treatment for Metastatic Non–Small-Cell Lung Cancer in CheckMate 227

Publikováno v: Journal of Clinical Oncology. 41:1200-1212

PURPOSE We present 5-year results from CheckMate 227 Part 1, in which nivolumab plus ipilimumab improved overall survival (OS) versus chemotherapy in patients with metastatic non–small-cell lung cancer, regardless of tumor programmed death ligand 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8b4a140d7d0dc05447ae536d36a8ed
https://doi.org/10.1200/jco.22.01503

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First-Line Nivolumab Plus Ipilimumab With Chemotherapy Versus Chemotherapy Alone for Metastatic NSCLC in CheckMate 9LA: 3-Year Clinical Update and Outcomes in Patients With Brain Metastases or Select Somatic Mutations

Publikováno v: Scientia

Non–small cell lung cancer; Brain metastases; Somatic mutations Càncer de pulmó de cèl·lules no petites; Metàstasis cerebrals; Mutacions somàtiques Cáncer de pulmón de células no pequeñas; Metástasis cerebrales; Mutaciones somáticas Int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1273c44ad3440298c0d6bb6ae78e198
https://doi.org/10.1016/j.jtho.2022.10.014

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Systemic and intracranial outcomes with first-line nivolumab plus ipilimumab in patients with metastatic non–small cell lung cancer and baseline brain metastases from CheckMate 227 Part 1

Publikováno v: Journal of Thoracic Oncology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74bfa2da3b17b9b98ecf986a2fa8bc01
https://doi.org/10.1016/j.jtho.2023.04.021

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Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks

Autor: Simon N. Powell, Andrew C. Bell, Laura J. Eccles

Publikováno v: DNA Repair. 64:1-9

When Fanconi Anemia (FA) proteins were depleted in human U2OS cells with integrated DNA repair reporters, we observed decreases in homologous recombination (HR), decreases in mutagenic non-homologous end joining (m-NHEJ) and increases in canonical NH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3013fc08a3966ac3d26e3eef1172e9
https://doi.org/10.1016/j.dnarep.2018.02.003

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Hierarchy of lesion processing governs the repair, double-strand break formation and mutability of three-lesion clustered DNA damage

Autor: Peter O'Neill, Martine E. Lomax, Laura J. Eccles

Publikováno v: Nucleic Acids Research

Ionising radiation induces clustered DNA damage sites which pose a severe challenge to the cell's repair machinery, particularly base excision repair. To date, most studies have focussed on two-lesion clusters. We have designed synthetic oligonucleot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9dc88e1455ddfea40e8a49c85e5155
https://doi.org/10.1093/nar/gkp1070

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Efficient cleavage of single and clustered AP site lesions within mono-nucleosome templates by CHO-K1 nuclear extract contrasts with retardation of incision by purified APE1

Autor: Laura J, Eccles, Hervé, Menoni, Dimitar, Angelov, Martine E, Lomax, Peter, O'Neill

Publikováno v: DNA Repair

Highlights • Retarded cleavage of abasic site when in nucleosomal DNA by AP endonuclease. • Efficient cleavage of abasic site when in nucleosomal DNA by CHO-K1 nuclear extracts. • Efficient cleavage of bistranded abasic sites in a cluster in nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71172962fcd16965d44005cde98539ab
https://pubmed.ncbi.nlm.nih.gov/26439176

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Abstract A03: The EMSY threonine 207 phospho-site is required for EMSY-driven suppression of DNA damage repair

Autor: Laura J. Eccles, Jill Tseng, Simon N. Powell, Petar Jelinic, Douglas A. Levine, Paulina Cybulska

Publikováno v: Molecular Cancer Research. 15:A03-A03

Introduction: EMSY, a putative DNA damage repair gene, is amplified in over 10% of high-grade serous ovarian carcinoma (HGSOC) cases. EMSY overexpression has been hypothesized to antagonize BRCA2 via direct interaction and compromise the homology-dir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a87219dfc6d9b0d747fbaebbc2bc6be
https://doi.org/10.1158/1557-3125.dnarepair16-a03

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Delayed repair of radiation induced clustered DNA damage: Friend or foe?

Autor: Laura J. Eccles, Martine E. Lomax, Peter O'Neill

Publikováno v: Mutation Research

A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. Clustered damage is made up of double strand bre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48295f71383287afbb813a70cd78b05
http://ora.ox.ac.uk/objects/uuid:63ac44d8-e0d9-4a8c-a5e8-1e6e06d34be8

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Abstract PR01: EMSY impairs DNA damage repair in a phosphorylation-dependent manner

Autor: Petar Jelinic, Simon N. Powell, Douglas A. Levine, Laura J. Eccles

Publikováno v: Clinical Cancer Research. 22:PR01-PR01

Background: EMSY, a putative DNA damage repair gene, is amplified in over 10% of high-grade serous ovarian carcinoma (HGSOC) cases. EMSY was initially identified as a BRCA2-interacting protein. Its overexpression has been hypothesized to antagonize B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da019d86f8644bb7de328acf60f4c70d
https://doi.org/10.1158/1557-3265.ovca15-pr01

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