Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Laura J, Blair"'
Autor:
Rekha S. Patel, Ashley Lui, Charles Hudson, Lauren Moss, Robert P. Sparks, Shannon E. Hill, Yan Shi, Jianfeng Cai, Laura J. Blair, Paula C. Bickford, Niketa A. Patel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Shifts in normal aging set stage for neurodegeneration and dementia affecting 1 in 10 adults. The study demonstrates that lncRNA GAS5 is decreased in aged and Alzheimer’s disease brain. The role and targets of lncRNA GAS5 in the aging brai
Externí odkaz:
https://doaj.org/article/7e1cfc1749fc453bb56dae844a64cc03
Autor:
Ryan Green, Karthick Mayilsamy, Andrew R. McGill, Taylor E. Martinez, Bala Chandran, Laura J. Blair, Paula C. Bickford, Shyam S. Mohapatra, Subhra Mohapatra
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 217-229 (2022)
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000 infections globally thus far. Up to 30% of individuals with mild to severe disease develop long COVID, exhibiting diverse neurologic symptoms including dementias. However, t
Externí odkaz:
https://doaj.org/article/f5788a47b7924c8db7fe23ddaa442896
Autor:
Marangelie Criado-Marrero, Danielle M. Blazier, Lauren A. Gould, Niat T. Gebru, Santiago Rodriguez Ospina, Debra S. Armendariz, April L. Darling, David Beaulieu-Abdelahad, Laura J. Blair
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Tau accumulation and progressive loss of neurons are associated with Alzheimer’s disease (AD). Aggregation of tau has been associated with endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR). While E
Externí odkaz:
https://doaj.org/article/64dff707852e4d75bac6a3dfb818855a
Autor:
Marangelie Criado-Marrero, Niat T. Gebru, Lauren A. Gould, Danielle M. Blazier, Yamile Vidal-Aguiar, Taylor M. Smith, Salma S. Abdelmaboud, Lindsey B. Shelton, Xinming Wang, Jan Dahrendorff, David Beaulieu-Abdelahad, Chad A. Dickey, Laura J. Blair
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract Abnormal accumulation of hyperphosphorylated tau induces pathogenesis in neurodegenerative diseases, like Alzheimer’s disease. Molecular chaperones with peptidyl-prolyl cis/trans isomerase (PPIase) activity are known to regulate these proc
Externí odkaz:
https://doaj.org/article/b06d2c045077424ca482d80168b5726e
Autor:
Marangelie Criado-Marrero, Niat T. Gebru, Danielle M. Blazier, Lauren A. Gould, Jeremy D. Baker, David Beaulieu-Abdelahad, Laura J. Blair
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract The microtubule associated protein tau is an intrinsically disordered phosphoprotein that accumulates under pathological conditions leading to formation of neurofibrillary tangles, a hallmark of Alzheimer’s disease (AD). The mechanisms tha
Externí odkaz:
https://doaj.org/article/96db6774e5134960a85eb9d69ac1073a
Autor:
Filippo Favretto, David Flores, Jeremy D. Baker, Timo Strohäker, Loren B. Andreas, Laura J. Blair, Stefan Becker, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Cyclophilin A (CypA) is a peptidylprolyl isomerase that also has chaperone activity and interacts with the intrinsically disordered protein α-Synuclein (aSyn). Here, the authors combine NMR measurements and biochemical experiments to characterise th
Externí odkaz:
https://doaj.org/article/f754601d5f914b7aaa2c4a5fef0fc9ba
Autor:
Yanan Zhu, Lauren Gandy, Fuming Zhang, Jian Liu, Chunyu Wang, Laura J. Blair, Robert J. Linhardt, Lianchun Wang
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1792 (2022)
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease, and are characterized by intraneuronal tau inclusion in the brain and the patient’s cognitive decline with obscure pathogenesis. Heparan sulfate proteoglycans,
Externí odkaz:
https://doaj.org/article/be7b1290ed8d49f9afda6cce318f64f8
Autor:
Leslie A. Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T. Calahatian, Devon S. Placides, Mallory D. Watler, Jerry B. Hunt, April L. Darling, Jeremy D. Baker, Laura J. Blair, Mackenzie D. Martin, Sarah N. Fontaine, Chad A. Dickey, April L. Lussier, Edwin J. Weeber, Maj-Linda B. Selenica, Kevin R. Nash, Marcia N. Gordon, Dave Morgan, Daniel C. Lee
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-24 (2019)
Abstract Background Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction between polyamine m
Externí odkaz:
https://doaj.org/article/f6fdfce93d6549e184299e4d7d512e9b
Autor:
Shannon E. Hill, David Beaulieu-Abdelahad, Andrea Lemus, Jack M. Webster, Santiago Rodriguez Ospina, April L. Darling, Mackenzie D. Martin, Shreya Patel, Liznair Bridenstine, Ronald Swonger, Steven Paul, Roy Blackburn, Laurent Calcul, Chad A. Dickey, James W. Leahy, Laura J. Blair
Publikováno v:
ACS Chemical Biology. 18:1124-1135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6129a08167a81c8a896513b79849deb0
https://doi.org/10.1021/acschembio.2c00919
https://doi.org/10.1021/acschembio.2c00919
Autor:
Marangelie Criado-Marrero, Taylor M. Smith, Lauren A. Gould, Sojeong Kim, Hannah J. Penny, Zheying Sun, Danielle Gulick, Chad A. Dickey, Laura J. Blair
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 9, Iss , Pp 100143- (2020)
Early life stress (ELS) adversely affects the brain and is commonly associated with the etiology of mental health disorders, like depression. In addition to the mood-related symptoms, patients with depression show dysregulation of the hypothalamic-pi
Externí odkaz:
https://doaj.org/article/1d59be1b34fb45a384cea2bd683efb31