Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Laura J, Bailey"'
Autor:
Ann Liza Piberger, Akhil Bowry, Richard D. W. Kelly, Alexandra K. Walker, Daniel González-Acosta, Laura J. Bailey, Aidan J. Doherty, Juan Méndez, Joanna R. Morris, Helen E. Bryant, Eva Petermann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Bulky DNA adducts are important replication-blocking lesions. Here the authors reveal that homologous recombination at bulky adducts in mammalian cells involves post-replicative gap repair in a PrimPol dependent manner.
Externí odkaz:
https://doaj.org/article/0f6811ec82d941be9a6362cf200f312d
Autor:
Mahmoud B. Maina, Laura J. Bailey, Sherin Wagih, Luca Biasetti, Saskia J. Pollack, James P. Quinn, Julian R. Thorpe, Aidan J. Doherty, Louise C. Serpell
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-13 (2018)
Abstract Tau is known for its pathological role in neurodegenerative diseases, including Alzheimer’s disease (AD) and other tauopathies. Tau is found in many subcellular compartments such as the cytosol and the nucleus. Although its normal role in
Externí odkaz:
https://doaj.org/article/a34deb81486543e3bd80a46007061673
Autor:
Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger, Benjamin A. Keen, Peter Kolesar, Elaine M. Taylor, Laura J. Bailey, Howard D. Lindsay, Walter J. Chazin, Aidan J. Doherty
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stim
Externí odkaz:
https://doaj.org/article/6c3b35c0421a4ab2b8722df6acbdcac6
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Alzheimer’s disease (AD) is the most common form of dementia and is distinguished from other dementias by observation of extracellular Amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles, comprised of fibrils of Aβ and tau protein,
Externí odkaz:
https://doaj.org/article/900f80d41ee14dfd87e27493d2b44a8a
Autor:
Laura J. Bailey, Rebecca Teague, Aidan J. Doherty, Howard D. Lindsay, Lewis J Bainbridge, Peter Kolesar
Publikováno v:
Science Advances
Description
PrimPol is regulated by PLK1 phosphorylation to restrict repriming and prevent genomic instability.
Replication stress and DNA damage stall replication forks and impede genome synthesis. During S phase, damage tolerance pathways
PrimPol is regulated by PLK1 phosphorylation to restrict repriming and prevent genomic instability.
Replication stress and DNA damage stall replication forks and impede genome synthesis. During S phase, damage tolerance pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b966009d07a42362160b90f9e6d66ce
http://sro.sussex.ac.uk/id/eprint/103390/3/sciadv.abh1004.pdf
http://sro.sussex.ac.uk/id/eprint/103390/3/sciadv.abh1004.pdf
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2277
In light of accumulating evidence suggestive of cell type-specific vulnerabilities as a result of normal aging processes that adversely affect the brain, as well as age-related neurodegenerative disorders such as Parkinson's disease (PD), the current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::169a9d5fb80438a038a36b1be2185f00
https://pubmed.ncbi.nlm.nih.gov/34080159
https://pubmed.ncbi.nlm.nih.gov/34080159
Publikováno v:
Methods in Molecular Biology ISBN: 9781071612699
In light of accumulating evidence suggestive of cell type-specific vulnerabilities as a result of normal aging processes that adversely affect the brain, as well as age-related neurodegenerative disorders such as Parkinson's disease (PD), the current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c552e19d07eecb71b72b8eedab3760f9
https://doi.org/10.1007/978-1-0716-1270-5_19
https://doi.org/10.1007/978-1-0716-1270-5_19
Publikováno v:
Nucleic Acids Research
Eukaryotic Primase-Polymerase (PrimPol) is an enzyme that maintains efficient DNA duplication by repriming replication restart downstream of replicase stalling lesions and structures. To elucidate the cellular requirements for PrimPol in human cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0156e0bc65ebe217a40ed4b139ca5b1f
http://sro.sussex.ac.uk/id/eprint/81543/8/gkz056.pdf
http://sro.sussex.ac.uk/id/eprint/81543/8/gkz056.pdf
Autor:
Davide, Schiavone, Stanislaw K, Jozwiakowski, Marina, Romanello, Guillaume, Guilbaud, Thomas A, Guilliam, Laura J, Bailey, Julian E, Sale, Aidan J, Doherty
Publikováno v:
Molecular Cell
Summary G quadruplexes (G4s) can present potent blocks to DNA replication. Accurate and timely replication of G4s in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epigenetic instability. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1a6deb57f0a2924d7b563e4b20f5e51e
http://europepmc.org/articles/PMC4712188
http://europepmc.org/articles/PMC4712188
Autor:
Laura J. Bailey, Maria Vinaixa, Andreu Casali, Pablo Pérez-Ferreros, Joana Silva, Lluís Ribas de Pouplana, Isabel Garcia-Cao, Travis H. Stracker, Alexis A. Jourdain, Acaimo González-Reyes, Etienne Coyaud, Philip A. Knobel, Oscar Yanes, Aidan J. Doherty, Ana M. Rojas, Suvi Aivio, Sara Samino-Gené, Albert Antolin-Fontes, Brian Raught
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Recercat. Dipósit de la Recerca de Catalunya
Universidad de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC
instname
Recercat. Dipósit de la Recerca de Catalunya
Mitochondria are subcellular organelles that are critical for meeting the bioenergetic and biosynthetic needs of the cell. Mitochondrial function relies on genes and RNA species encoded both in the nucleus and mitochondria, and on their coordinated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab44f9cd002f97e590210270d54d10fe
http://hdl.handle.net/2445/119822
http://hdl.handle.net/2445/119822