Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Laura Iavarone"'
Autor:
Tae Eun Yang, Francesca Del Bene, Silvia Maria Lavezzi, Laura Iavarone, Jianping Zhang, Joseph Kim, Breanne Gjurich, Catherine Kessler
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 10, Pp 1722-1733 (2024)
Abstract The purpose of the analysis was to evaluate if 10 mg naloxone, administered intramuscularly, could reverse or prevent opioid‐induced respiratory depression (OIRD), including OIRD associated with the administration of lethal doses of high
Externí odkaz:
https://doaj.org/article/6ec5dd1f556e43ccbdc4e82c89924c8a
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 8, Pp 1029-1044 (2022)
Abstract Pharmacokinetic/pharmacodynamic (PK/PD) indices making use of area under the curve, maximum concentration, and the duration that in vivo drug concentration is maintained above a critical level are commonly applied to clinical dose prediction
Externí odkaz:
https://doaj.org/article/0fc13f2498c840dcbd96f6a923a4f6c4
Autor:
Susanne Becker, Laura Iavarone, Matthias Grossmann, Jan H. Boergermann, Niels-Peter Becker, Ingolf Schimke, Angela Sinn, Peter Göttel, Anne-Sophie Hönicke, Sabine Bartel, Annekathrin Haberland, Katrin Wenzel, Gerd Wallukat, Kiley Prilliman, Sarah Schulze-Rothe, Hanna Davideit, Johannes Müller, Georg Golor
Publikováno v:
Clinical Drug Investigation
Background and Objective BC 007 is a substance with a novel and innovative mode of action for the first-time causal treatment of chronic heart failure, associated with the occurrence of autoantibodies against the β1-adrenoceptor, and other diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6533eb8c8c4e38c443ebc8778c68acad
https://doi.org/10.1007/s40261-020-00903-9
https://doi.org/10.1007/s40261-020-00903-9
Autor:
Hannah J. Pearce, Ian Gurrell, Neil J. Flanagan, Alex Phipps, Hannah M. Jones, Jill Segelbacher, Bill Speed, Daniela Fraier, Tanya Hay, Rob Webster, Paweł Dżygiel, Richard P. Butt, Laura Iavarone, Kevin Beaumont, Jacquelynn Luckwell
Publikováno v:
Clinical Pharmacokinetics. 55:875-887
The emergence of genetic data linking Nav1.7 sodium channel over- and under- expression to human pain signalling has led to an interest in the treatment of chronic pain through inhibition of Nav1.7 channels. We describe the pharmacokinetic (PK) resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b055914554d3aec84230cf21de972e53
https://doi.org/10.1007/s40262-015-0365-0
https://doi.org/10.1007/s40262-015-0365-0
Autor:
Laura Iavarone, Raulin Surujbally, Simon Kirby, Zahid Ali, Richard P. Butt, Aoibhinn McDonnell, Susie Collins
Publikováno v:
Pain. 159(8)
The effect of PF-05089771, a selective, peripherally restricted Nav1.7 sodium channel blocker on pain due to diabetic peripheral neuropathy was investigated in a randomised, placebo and active-controlled parallel group clinical trial (NCT02215252). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c0f1b5b78b7ee0f98fa19fe7928b72
https://pubmed.ncbi.nlm.nih.gov/29578944
https://pubmed.ncbi.nlm.nih.gov/29578944
Autor:
Paul Shotbolt, Laura Iavarone, Eugenii A. Rabiner, Marta Neve, Marcella Petrone, Marc Laruelle, Cristian Salinas, Jasper van der Aart, Roberto Gomeni, Mark Slifstein, Robert A. Comley, Carmine Marzano, Idriss Bennacef, Frank A Gray, Roger N. Gunn
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 346:311-317
The selection of a therapeutically meaningful dose of a novel pharmaceutical is a crucial step in drug development. Positron emission tomography (PET) allows the in vivo estimation of the relationship between the plasma concentration of a drug and it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971fee16f3b217813cdb710b99a45977
https://doi.org/10.1124/jpet.112.202895
https://doi.org/10.1124/jpet.112.202895
Autor:
Keith T. Muir, Claire F. Brittain, Giulia Ghibellini, Norman Levy, Joohyun Park, Laura Iavarone, Anne C. Andorn
Publikováno v:
The Journal of Clinical Pharmacology. 49:489-495
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159397fdd24398f447f52362ca34fb5e
https://doi.org/10.1177/0091270008330981
https://doi.org/10.1177/0091270008330981
Publikováno v:
British Journal of Clinical Pharmacology. 54:407-414
Aims To investigate whether saliva is a useful alternative to plasma for routine monitoring of nicotine and evaluate the predictive performances of saliva and plasma concentration on craving estimated by a Tiffany Questionnaire on Smoking Urge-Brief
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1d12df7081a3d1a1c88a10748435dd3
https://doi.org/10.1046/j.0306-5251.2002.01650.x
https://doi.org/10.1046/j.0306-5251.2002.01650.x
Autor:
Jasper van der Aart, Christer Halldin, Robert A. Comley, Balázs Gulyás, Martine Garnier, Eugenii A. Rabiner, Laura Iavarone
Publikováno v:
Neuropharmacology. 92
5-hydroxytryptamine 1 (5-HT 1 ) receptor blockade in combination with serotonin reuptake inhibition may provide a more rapid elevation of synaptic 5-HT compared to serotonin reuptake alone, by blocking the inhibitory effect of 5-HT 1 receptor activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b5aba6268bcc4c546cc01cc1d4d0a7
https://pubmed.ncbi.nlm.nih.gov/25476970
https://pubmed.ncbi.nlm.nih.gov/25476970
Publikováno v:
British Journal of Clinical Pharmacology. 51:147-152
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33a16bb62c9d61efb8b3db61f897d425
https://doi.org/10.1111/j.1365-2125.2001.bjcp119.x
https://doi.org/10.1111/j.1365-2125.2001.bjcp119.x