Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Laura I. Cosen-Binker"'
Publikováno v:
Canadian Journal of Gastroenterology, Vol 21, Iss 1, Pp 19-24 (2007)
In acute pancreatitis, initiating cellular events causing acinar cell injury includes co-localization of zymogens with lysosomal hydrolases, leading to premature enzyme activation and pathological exocytosis of zymogens into the interstitial space. T
Externí odkaz:
https://doaj.org/article/9d8014bb4f204ae7b58841b155a76527
Autor:
Mark S. Cattral, Li Xie, Erin Winter, Laura I. Cosen-Binker, Tao Liang, Subhankar Dolai, Herbert Y. Gaisano, Ya Chi Huang, Peter Thorn, Negar Karimian, Abrahim I. Orabi
Publikováno v:
Journal of Biological Chemistry. 292:5957-5969
A genuine understanding of human exocrine pancreas biology and pathobiology has been hampered by a lack of suitable preparations and reliance on rodent models employing dispersed acini preparations. We have developed an organotypic slice preparation
Autor:
Herbert Y. Gaisano, Daniel Richards, Brenda Oliver, Marcelo G. Binker, Laura I. Cosen-Binker, Makena J. Binker-Cosen
Publikováno v:
Biochemical and Biophysical Research Communications. 484:152-158
Pancreatic cancer (PC) is an aggressive malady with proclivity for early metastasis. Overexpression of toll-like receptor 4 (TLR4) in pancreatic ductal adenocarcinoma, the most common type of pancreatic malignancy, correlates to tumor size, lymph nod
Autor:
Herbert Y. Gaisano, Andres A. Binker-Cosen, Marcelo G. Binker, Rodica H. de Cosen, Laura I. Cosen-Binker
Publikováno v:
Biochemical and Biophysical Research Communications. 405:140-145
Human pancreatic cancer invasion and metastasis have been found to correlate with increased levels of active matrix metalloproteinase 2 (MMP-2). The multifunctional cytokine transforming growth factor beta 1 (TGF-β1) has been shown to increase both
Autor:
Rodica H. de Cosen, Herbert Y. Gaisano, Andres A. Binker-Cosen, Daniel Richards, Marcelo G. Binker, Laura I. Cosen-Binker
Publikováno v:
Biochemical and Biophysical Research Communications. 393:371-376
Pancreatic cancer is an aggressive malignancy with proclivity to early metastasis. High expression and activation of the collagenase matrix metalloproteinase-2 (MMP-2) have been found in human pancreatic cancer tissues, being these increased levels o
Publikováno v:
Experimental Physiology. 93:1091-1103
Pancreatitis is a disease with high morbidity and mortality. In vitro experiments on pancreatic acini showed that supramaximal but not submaximal cholecystokinin (CCK) stimulation induces effects in the acinar cell that can be correlated with acinar
Autor:
Aurelia Lugea, Herbert Y. Gaisano, Laura I. Cosen Binker, Patrick P.L. Lam, Stephen J. Pandol
Publikováno v:
Traffic. 8:605-617
The molecular mechanism of clinical alcohol-induced pancreatitis remains vague. We had reported that experimental high-dose cholecystokinin (CCK)-induced pancreatitis is in part because of excessive aberrant basolateral exocytosis. High-dose CCK caus
Autor:
Daniel Richards, Marcelo G. Binker, Makena J. Binker-Cosen, Laura I. Cosen-Binker, Andres A. Binker-Cosen, Steven D. Freedman
Publikováno v:
Biochemical and biophysical research communications. 463(4)
Chronic obstructive pulmonary disease (COPD) is an inflammatory process characterized by airway mucus hypersecretion. Lipopolysaccharides (LPS) are known to stimulate the production of mucin 5AC (MUC5AC) via epidermal growth factor receptor (EGFR) in
Publikováno v:
Biochemical and biophysical research communications. 463(3)
Pancreatitis has been suspected for a long time to have an autodigestive genesis. The main events occurring in the pancreatic acinar cell that initiate acute pancreatitis include inhibition of zymogen secretion and intracellular activation of proteas
Autor:
Laura I. Cosen-Binker, Andras Kapus
Publikováno v:
Physiology. 21:352-361
Cortactin, an actin filament-binding protein and target of multiple kinases, has emerged as a central element connecting signaling pathways with cytoskeleton restructuring. It is involved in a perplexingly diverse array of cellular processes, includi