Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laura High"'
Autor:
Richard B. Lock, Malcolm A. Smith, Peter J. Houghton, Jean-Pierre Bourquin, Anthony Letai, Warren Kaplan, Catherine Billups, Raushan T. Kurmasheva, Donya Moradi Manesh, Luke Jones, Elise Tonna, Ingrid Boehm, Kathryn Evans, Barbara Szymanska, Mark J. Cowley, Beat Bornhauser, Laura High, Chintanu Sarmah, Viktoras Frismantas, Triona Ni Chonghaile, Hernan Carol, Santi Suryani
Supplementary Figures S6-S9. Correlations between BCL2 family gene expression and in vivo ABT-263 sensitivity in the MLL-ALL xenograft panel; S7. Correlations between BCL2 family gene expression and in vivo ABT-263 sensitivity in the BCP-ALL xenograf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c22210571e10a4ce36db4d779b4d55
https://doi.org/10.1158/1078-0432.22454406
https://doi.org/10.1158/1078-0432.22454406
Autor:
Richard B. Lock, Malcolm A. Smith, Peter J. Houghton, Ursula R. Kees, Raushan T. Kurmasheva, Rosemary Sutton, Michelle Henderson, Rolf Marschalek, Nicola C. Venn, Claus Meyer, Alissa Robbins, Agnes Mendomo, Laura High, Kathryn Evans, Hernan Carol, Jennifer Richmond
Purpose: Although the overall cure rate for pediatric acute lymphoblastic leukemia (ALL) approaches 90%, infants with ALL harboring translocations in the mixed-lineage leukemia (MLL) oncogene (infant MLL-ALL) experience shorter remission duration and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bf87e6335e7a7822cde679b3f889a5
https://doi.org/10.1158/1078-0432.c.6523841.v1
https://doi.org/10.1158/1078-0432.c.6523841.v1
Autor:
Richard B. Lock, Malcolm A. Smith, Peter J. Houghton, Ursula R. Kees, Raushan T. Kurmasheva, Rosemary Sutton, Michelle Henderson, Rolf Marschalek, Nicola C. Venn, Claus Meyer, Alissa Robbins, Agnes Mendomo, Laura High, Kathryn Evans, Hernan Carol, Jennifer Richmond
This file contains Supplementary Methods describing the Pediatric Preclinical Testing Program (PPTP) scoring method. Supplementary Figure S1: Engraftment rates and organ infiltration of MLL-ALL xenografts. Supplementary Figure S2: Comparison of expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e93c2b703ef1ac3f697bc47daba6b25
https://doi.org/10.1158/1078-0432.22458131
https://doi.org/10.1158/1078-0432.22458131
Autor:
Robert Traficante, David M. Ross, Evren Zor, Nicholas Viiala, Devendra K Hiwase, Raj Ramakrishna, Phoebe Joy Ho, Donald K. Bowden, Laura High, Ann Solterbeck, Othon L Gervasio
Publikováno v:
HemaSphere
HemaSphere, Vol 3, Iss 3 (2019)
HemaSphere, Vol 3, Iss 3 (2019)
Supplemental Digital Content is available in the text
The significant morbidity and mortality associated with iron overload can be reduced by effective iron chelation. Magnetic resonance imaging (MRI) provides accurate and reproducible iron load
The significant morbidity and mortality associated with iron overload can be reduced by effective iron chelation. Magnetic resonance imaging (MRI) provides accurate and reproducible iron load
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0319508cbed3317510f137b1e1cc64d6
https://pubmed.ncbi.nlm.nih.gov/31723837
https://pubmed.ncbi.nlm.nih.gov/31723837
Autor:
Rosemary Sutton, Michelle J. Henderson, Hernan Carol, Laura High, Claus Meyer, Nicola C. Venn, Malcolm A. Smith, Alissa Robbins, Ursula R. Kees, Rolf Marschalek, Raushan T. Kurmasheva, Peter J. Houghton, Jennifer Richmond, Kathryn Evans, Agnes M. Mendomo, Richard B. Lock
Publikováno v:
Clinical Cancer Research. 21:1395-1405
Purpose: Although the overall cure rate for pediatric acute lymphoblastic leukemia (ALL) approaches 90%, infants with ALL harboring translocations in the mixed-lineage leukemia (MLL) oncogene (infant MLL-ALL) experience shorter remission duration and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edd26207fe22a487dc5c8d5bd5a974d
https://doi.org/10.1158/1078-0432.ccr-14-2300
https://doi.org/10.1158/1078-0432.ccr-14-2300
Autor:
Raushan T. Kurmasheva, Barbara Szymanska, Santi Suryani, Mark J. Cowley, Ingrid Boehm, Triona Ni Chonghaile, Warren Kaplan, Hernan Carol, Donya Moradi Manesh, Laura High, Luke Jones, Peter J. Houghton, Jean-Pierre Bourquin, Elise Tonna, Malcolm A. Smith, Chintanu Sarmah, Viktoras Frismantas, Catherine A. Billups, Richard B. Lock, Kathryn Evans, Beat Bornhauser, Anthony Letai
Purpose: Predictive biomarkers are required to identify patients who may benefit from the use of BH3 mimetics such as ABT-263. This study investigated the efficacy of ABT-263 against a panel of patient-derived pediatric acute lymphoblastic leukemia (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597045feea2bc0969a2fcd09c3651026
https://www.zora.uzh.ch/id/eprint/101257/
https://www.zora.uzh.ch/id/eprint/101257/
Autor:
Rosemary O'Brien, Richard B. Lock, Laura High, Urszula Wilczynska-Kalak, Andrew W. Roberts, Barbara Szymanska, Seong Lin Khaw, Nicole Barber, Ingela B. Vikstrom
Publikováno v:
Molecular pharmacology. 77(3)
Antiapoptotic Bcl-2 proteins are overexpressed in a number of cancers, including leukemias, and are frequently associated with resistance to conventional chemotherapeutic drugs. ABT-737, a Bcl-2 homology domain 3 mimetic (for structure, see Nature 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed94e19737f26b5e66d7eea1678796c
https://pubmed.ncbi.nlm.nih.gov/20038611
https://pubmed.ncbi.nlm.nih.gov/20038611
Autor:
Raushan T. Kurmasheva, Hernan Carol, Laura High, Malcolm A. Smith, Richard B. Lock, Kathryn Evans, Peter J. Houghton, Agnes M. Mendomo, Jennifer Richmond
Publikováno v:
Blood. 122:71-71
Introduction While the overall cure rate for the most common pediatric cancer, acute lymphoblastic leukemia (ALL) now approaches 90%, infants ( Methods In vitro cytotoxicity was assessed by mitochondrial metabolic activity assay (Alamar blue) followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daccfba9a2fb2ae59fc1f57ddd5ea244
https://doi.org/10.1182/blood.v122.21.71.71
https://doi.org/10.1182/blood.v122.21.71.71
Publikováno v:
Cancer Research. 71:LB-23
The development of acquired resistance to chemotherapy in the clinic remains a major obstacle to improve patient outcome and a better understanding of the underlying molecular events is essential to target refractory cancers, including leukemia. Infa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdadcf1d86c0068f492322f25a968366
https://doi.org/10.1158/1538-7445.am2011-lb-23
https://doi.org/10.1158/1538-7445.am2011-lb-23
Autor:
Laura Highcock, Alecia J Carter
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95179 (2014)
Animals do not behave in exactly the same way when repeatedly tested in the same context or situation, even once systematic variation, such as habituation, has been controlled for. This unpredictability is called intraindividual variability (IIV) and
Externí odkaz:
https://doaj.org/article/1b78256a761a4c5fb72631350d4110e8