Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Laura Hertz"'
The Gárdos Channel and Piezo1 Revisited: Comparison between Reticulocytes and Mature Red Blood Cells
Autor:
Polina Petkova-Kirova, Nicoletta Murciano, Giulia Iacono, Julia Jansen, Greta Simionato, Min Qiao, Carmen Van der Zwaan, Maria Giustina Rotordam, Thomas John, Laura Hertz, Arjan J. Hoogendijk, Nadine Becker, Christian Wagner, Marieke Von Lindern, Stephane Egee, Emile Van den Akker, Lars Kaestner
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1416 (2024)
The Gárdos channel (KCNN4) and Piezo1 are the best-known ion channels in the red blood cell (RBC) membrane. Nevertheless, the quantitative electrophysiological behavior of RBCs and its heterogeneity are still not completely understood. Here, we use
Externí odkaz:
https://doaj.org/article/e25eaf0b23bd429f9d46c6d460cc6f55
Autor:
Ching-Sheng Hsu, Wei-Liang Liu, Qisheng Li, Brianna Lowey, Laura Hertz, You-Chen Chao, T. Jake Liang, Ding-Shinn Chen, Jia-Horng Kao
Publikováno v:
Journal of the Formosan Medical Association, Vol 119, Iss 9, Pp 1382-1395 (2020)
Background: Patients with different hepatitis C virus (HCV) genotype infections are associated with varying metabolic disorders. Although alteration of lipid metabolism has been confirmed as a virus-induced metabolic derangement in chronic hepatitis
Externí odkaz:
https://doaj.org/article/7664b93fea174a54ac172da0de9634da
Autor:
Rick Huisjes, Asya Makhro, Esther Llaudet-Planas, Laura Hertz, Polina Petkova-Kirova, Liesbeth P. Verhagen, Silvia Pignatelli, Minke A.E. Rab, Raymond M. Schiffelers, Elena Seiler, Wouter W. van Solinge, Joan-LLuis Vives Corrons, Lars Kaestner, Maria Mañú-Pereira, Anna Bogdanova, Richard van Wijk
Publikováno v:
Haematologica, Vol 105, Iss 2 (2020)
Hereditary spherocytosis (HS) originates from defective anchoring of the cytoskeletal network to the transmembrane protein complexes of the red blood cell (RBC). Red cells in HS are characterized by membrane instability and reduced deformability and
Externí odkaz:
https://doaj.org/article/1c68fad6745d4dcf9f1217dde473aff1
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
Externí odkaz:
https://doaj.org/article/5237a523e7e3448d9073e92ec33686b0
Autor:
Elisa Fermo, Anna Bogdanova, Polina Petkova-Kirova, Anna Zaninoni, Anna Paola Marcello, Asya Makhro, Pascal Hänggi, Laura Hertz, Jens Danielczok, Cristina Vercellati, Nadia Mirra, Alberto Zanella, Agostino Cortelezzi, Wilma Barcellini, Lars Kaestner, Paola Bianchi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The Gardos channel is a Ca2+ sensitive, K+ selective channel present in several tissues including RBCs, where it is involved in cell volume regulation. Recently, mutations at two different aminoacid residues in KCNN4 have been reported in pa
Externí odkaz:
https://doaj.org/article/59b33391f2f1464aa72773d45d39ea5d
Autor:
Jens Danielczok, Laura Hertz, Sandra Ruppenthal, Elisabeth Kaiser, Polina Petkova-Kirova, Anna Bogdanova, Elmar Krause, Peter Lipp, Marc Freichel, Lars Kaestner, Lutz Birnbaumer
Publikováno v:
Cellular Physiology and Biochemistry, Vol 41, Iss 3, Pp 1219-1228 (2017)
Background: Cation channels play an essential role in red blood cells (RBCs) ion homeostasis. One set of ion channels are the transient receptor potential channels of canonical type (TRPC channels). The abundance of these channels in primary erythrob
Externí odkaz:
https://doaj.org/article/a89af9b5715e46de94de0796aaa77dc3
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Hepatitis C virus (HCV) harnesses host dependencies to infect human hepatocytes. We previously identified a pivotal role of IκB kinase α (IKK-α) in regulating cellular lipogenesis and HCV assembly. In this study, we defined and characteri
Externí odkaz:
https://doaj.org/article/e59efabd77914dc6b864d606912cfb20
Autor:
Laura Hertz, Sandra Ruppenthal, Greta Simionato, Stephan Quint, Alexander Kihm, Asena Abay, Polina Petkova-Kirova, Ulrich Boehm, Petra Weissgerber, Christian Wagner, Matthias W. Laschke, Lars Kaestner
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Very young red blood cells, namely reticulocytes, can be quite easily recognized and labeled by cluster of differentiation antibodies (CD71, transferrin receptor) or by staining remnant RNA with thiazol orange. In contrast, age specific erythrocyte l
Externí odkaz:
https://doaj.org/article/aaccfc17d6ed47bd8c5950745801a87b
Autor:
Asena Abay, Greta Simionato, Revaz Chachanidze, Anna Bogdanova, Laura Hertz, Paola Bianchi, Emile van den Akker, Marieke von Lindern, Marc Leonetti, Giampaolo Minetti, Christian Wagner, Lars Kaestner
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Glutaraldehyde is a well-known substance used in biomedical research to fix cells. Since hemolytic anemias are often associated with red blood cell shape changes deviating from the biconcave disk shape, conservation of these shapes for imaging in gen
Externí odkaz:
https://doaj.org/article/2aa2635fd5e14a648381478ca41559be
Autor:
Polina Petkova-Kirova, Laura Hertz, Jens Danielczok, Rick Huisjes, Asya Makhro, Anna Bogdanova, Maria del Mar Mañú-Pereira, Joan-Lluis Vives Corrons, Richard van Wijk, Lars Kaestner
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Congenital haemolytic anaemias are inherited disorders caused by red blood cell membrane and cytoskeletal protein defects, deviant hemoglobin synthesis and metabolic enzyme deficiencies. In many cases, although the causing mutation might be known, th
Externí odkaz:
https://doaj.org/article/cdc57bf2bc5d44bd890bd3e4f2390861