Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Laura Hertel"'
Publikováno v:
Viruses, Vol 15, Iss 4, p 1023 (2023)
Human cytomegalovirus (CMV) has evolved to replicate while causing minimal damage, maintain life-long latency, reactivate sub-clinically, and, in spite of robust host immunity, produce and shed infectious virus in order to transmit to new hosts. The
Externí odkaz:
https://doaj.org/article/fcadb31ef201455b8a3e97014cd61b60
Autor:
Ahmed Al Qaffas, Salvatore Camiolo, Mai Vo, Alexis Aguiar, Amine Ourahmane, Myrna Sorono, Andrew J. Davison, Michael A. McVoy, Laura Hertel
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-5 (2021)
Abstract The advent of whole genome sequencing has revealed that common laboratory strains of human cytomegalovirus (HCMV) have major genetic deficiencies resulting from serial passage in fibroblasts. In particular, tropism for epithelial and endothe
Externí odkaz:
https://doaj.org/article/0d3893ac1de14cec90e1fa6f65918b77
Autor:
Ying Qi, Li He, Xiaohong Cui, Laura Hertel, Daniel C. Freed, Tong-Ming Fu, Lawrence M. Kauvar, Michael A. McVoy, Qiang Ruan
Publikováno v:
Virology Journal, Vol 17, Iss 1, Pp 1-7 (2020)
Abstract Antibody neutralization of cytomegalovirus (CMV) entry into diverse cell types is a key consideration for development of vaccines and immunotherapeutics. CMV entry into fibroblasts differs significantly from entry into epithelial or endothel
Externí odkaz:
https://doaj.org/article/8f1024c2a3ed43b395ff4e6e9054c92e
Autor:
Li He, Scott Taylor, Catherine Costa, Irene Görzer, Julia Kalser, Tong-Ming Fu, Daniel Freed, Dai Wang, Xiaohong Cui, Laura Hertel, Michael A. McVoy
Publikováno v:
Viruses, Vol 14, Iss 7, p 1508 (2022)
Human cytomegalovirus (CMV) utilizes different glycoproteins to enter into fibroblast and epithelial cells. A trimer of glycoproteins H, L, and O (gH/gL/gO) is required for entry into all cells, whereas a pentamer of gH/gL/UL128/UL130/UL131A is selec
Externí odkaz:
https://doaj.org/article/f53ac58d9321492f85e4499f1e9696d5
Autor:
Alexis Aguiar, Melissa Galinato, Maite’ Bradley Silva, Bryant Toth, Michael A. McVoy, Laura Hertel
Publikováno v:
Viruses, Vol 13, Iss 12, p 2355 (2021)
Only a handful of cell types, including fibroblasts, epithelial, and endothelial cells, can support human cytomegalovirus (CMV) replication in vitro, in striking contrast to the situation in vivo. While the susceptibility of epithelial and endothelia
Externí odkaz:
https://doaj.org/article/7bbed46d1b8644bd800e917b2aff278c
Autor:
Melissa Galinato, Kristen Shimoda, Alexis Aguiar, Fiona Hennig, Dario Boffelli, Michael A. McVoy, Laura Hertel
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Myeloid cells are important sites of lytic and latent infection by human cytomegalovirus (CMV). We previously showed that only a small subset of myeloid cells differentiated from CD34+ hematopoietic stem cells is permissive to CMV replication, unders
Externí odkaz:
https://doaj.org/article/bc5153a894ae4ca19e0fc84b21e08644
Publikováno v:
Microorganisms, Vol 8, Iss 4, p 615 (2020)
Despite displaying broad tropism in vivo, human cytomegalovirus (CMV) contained in bodily fluids replicates inefficiently in most cultured cell types except fibroblasts. As propagation in fibroblasts leads to the accumulation of genomic changes, a nu
Externí odkaz:
https://doaj.org/article/7e7ed02c45434c2cb0301864f6756aba
Autor:
Amine Ourahmane, Xiaohong Cui, Li He, Meaghan Catron, Dirk P. Dittmer, Ahmed Al Qaffasaa, Mark R. Schleiss, Laura Hertel, Michael A. McVoy
Publikováno v:
Viruses, Vol 11, Iss 3, p 221 (2019)
Propagation of human cytomegalovirus (CMV) in cultured cells results in genetic adaptations that confer improved growth in vitro and significant attenuation in vivo. Mutations in RL13 arise quickly, while mutations in the UL128-131A locus emerge late
Externí odkaz:
https://doaj.org/article/367d344ca2924b69829d92b63a7925af
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Oral mucosal Langerhans cells (LC) are likely to play important roles in host defense against infection by human cytomegalovirus (CMV). We previously showed that in vitro-differentiated immature LC (iLC) populations contain smaller amounts of infecte
Externí odkaz:
https://doaj.org/article/d6666a72532c4e7aa05598410bda6a41
Autor:
Laura Hertel
Publikováno v:
Viruses, Vol 3, Iss 7, Pp 1015-1040 (2011)
Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to s
Externí odkaz:
https://doaj.org/article/132d1348d40944e8affc5cc864318264