Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Laura Hellinen"'
Autor:
Laura Hellinen, Ali Koskela, Elina Vattulainen, Mikko Liukkonen, Christine Wegler, Andrea Treyer, Niklas Handin, Richard Svensson, Timo Myöhänen, Antti Poso, Kai Kaarniranta, Per Artursson, Arto Urtti
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112501- (2022)
Dry age-related macular degeneration (AMD) is a currently untreatable vision threatening disease. Impaired proteasomal clearance and autophagy in the retinal pigment epithelium (RPE) and subsequent photoreceptor damage are connected with dry AMD, but
Externí odkaz:
https://doaj.org/article/ff9ee91632444222beb7327553911625
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 635 (2022)
The published article [...]
Externí odkaz:
https://doaj.org/article/ae023e2ed92f43e2b2ed1d789749a06d
Autor:
Laura Hellinen, Heidi Hongisto, Eva Ramsay, Kai Kaarniranta, Kati-Sisko Vellonen, Heli Skottman, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 595 (2022)
The published article [...]
Externí odkaz:
https://doaj.org/article/fa8a6a9506b34194851652778e0765fe
Autor:
Tommi P. Kilpeläinen, Laura Hellinen, Johannes Vrijdag, Xu Yan, Reinis Svarcbahs, Kati-Sisko Vellonen, Anne-Marie Lambeir, Henri Huttunen, Arto Urtti, Erik A.A Wallen, Timo T. Myöhänen
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 128, Iss , Pp 110253- (2020)
Previous studies have shown that prolyl oligopeptidase (PREP) negatively regulates autophagy and increases the aggregation of alpha-synuclein (αSyn), linking it to the pathophysiology of Parkinson’s disease. Our earlier results have revealed that
Externí odkaz:
https://doaj.org/article/b37f7e68804249f1ba836358a446836a
Autor:
Elisa Toropainen, Sara J. Fraser-Miller, Dunja Novakovic, Eva M. Del Amo, Kati-Sisko Vellonen, Marika Ruponen, Tapani Viitala, Ossi Korhonen, Seppo Auriola, Laura Hellinen, Mika Reinisalo, Unni Tengvall, Stephanie Choi, Mohammad Absar, Clare Strachan, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 13, Iss 4, p 452 (2021)
Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated
Externí odkaz:
https://doaj.org/article/2af1e0b88b534519bb185694d6e37fe4
Autor:
Laura Hellinen, Sina Bahrpeyma, Anna-Kaisa Rimpelä, Marja Hagström, Mika Reinisalo, Arto Urtti
Publikováno v:
Pharmaceutics, Vol 12, Iss 6, p 554 (2020)
Interactions between drugs and melanin pigment may have major impacts on pharmacokinetics. Therefore, melanin binding can modify the efficacy and toxicity of medications in ophthalmic and other disease of pigmented tissues, such as melanoma. As melan
Externí odkaz:
https://doaj.org/article/5aa019cdeee841dabc45578783f50f16
Autor:
Laura Hellinen, Heidi Hongisto, Eva Ramsay, Kai Kaarniranta, Kati-Sisko Vellonen, Heli Skottman, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 176 (2020)
The retinal pigment epithelial (RPE) cell monolayer forms the outer blood−retinal barrier and has a crucial role in ocular pharmacokinetics. Although several RPE cell models are available, there have been no systematic comparisons of their barrier
Externí odkaz:
https://doaj.org/article/8ee02da0d3944372a3092b7c49eff940
Publikováno v:
Pharmaceutics, Vol 11, Iss 8, p 412 (2019)
Retinal pigment epithelium (RPE) acts as an outer blood−retinal barrier that limits the access of circulating xenobiotics to the eye. In addition, the RPE limits posterior elimination of intravitreally injected drugs to circulation. Thus, permeatio
Externí odkaz:
https://doaj.org/article/cd4a1eeeb6884dafa2025a683c22efe2
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 348
Melanin binding of drugs is known to increase drug concentrations and retention in pigmented eye tissues. Even though the correlation between melanin binding in vitro and exposure to pigmented eye in vivo has been shown, there is a discrepancy betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ee1757719fc18fc089dccd0d5c4965
https://pubmed.ncbi.nlm.nih.gov/35738465
https://pubmed.ncbi.nlm.nih.gov/35738465
Autor:
Laura Hellinen, Heidi Hongisto, Eva Ramsay, Kai Kaarniranta, Kati-Sisko Vellonen, Heli Skottman, Marika Ruponen
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0aa633a3e3403104808ce88f634e47
https://doi.org/10.2139/ssrn.4093938
https://doi.org/10.2139/ssrn.4093938