Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Laura Heiser"'
Autor:
Luke Ternes, Mark Dane, Sean Gross, Marilyne Labrie, Gordon Mills, Joe Gray, Laura Heiser, Young Hwan Chang
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
The Multi-Encoder Variational AutoEncoder (ME-VAE) is a computational model that can control for multiple transformational features in single-cell imaging data, enabling researchers to extract meaningful single-cell information and better separate he
Externí odkaz:
https://doaj.org/article/62591d36456a47f795a757db9843ff3a
Autor:
Joseph P. Garay, Rebecca Smith, Kaylyn Devlin, Daniel P. Hollern, Tiera Liby, Moqing Liu, Shanta Boddapati, Spencer S. Watson, Amanda Esch, Ting Zheng, Wallace Thompson, Darcie Babcock, Sunjong Kwon, Koei Chin, Laura Heiser, Joe W. Gray, James E. Korkola
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-17 (2021)
Abstract Background HER2-amplified breast cancer is a clinically defined subtype of breast cancer for which there are multiple viable targeted therapies. Resistance to these targeted therapies is a common problem, but the mechanisms by which resistan
Externí odkaz:
https://doaj.org/article/8c8e2b0cbc1d479e8a286db82615c089
Autor:
Rebecca Smith, Moqing Liu, Tiera Liby, Nora Bayani, Elmar Bucher, Kami Chiotti, Daniel Derrick, Anne Chauchereau, Laura Heiser, Joshi Alumkal, Heidi Feiler, Peter Carroll, James E. Korkola
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Representative in vitro model systems that accurately model response to therapy and allow the identification of new targets are important for improving our treatment of prostate cancer. Here we describe molecular characterization and drug te
Externí odkaz:
https://doaj.org/article/708df8dc657045d19f9756d95d497a15
Autor:
Lauren Anton, Luz-Jeannette Sierra, Ann DeVine, Guillermo Barila, Laura Heiser, Amy G. Brown, Michal A. Elovitz
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Cervicovaginal (CV) microbiota is associated with vaginal health and disease in non-pregnant women. Recent studies in pregnant women suggest that specific CV microbes are associated with preterm birth (PTB). While the associations between CV microbio
Externí odkaz:
https://doaj.org/article/502c5ee01ed5471695487a203fe00a37
Autor:
James E Korkola, Eric A Collisson, Laura Heiser, Chris Oates, Nora Bayani, Sleiman Itani, Amanda Esch, Wallace Thompson, Obi L Griffith, Nicholas J Wang, Wen-Lin Kuo, Brian Cooper, Jessica Billig, Safiyyah Ziyad, Jenny L Hung, Lakshmi Jakkula, Heidi Feiler, Yiling Lu, Gordon B Mills, Paul T Spellman, Claire Tomlin, Sach Mukherjee, Joe W Gray
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133219 (2015)
We report here on experimental and theoretical efforts to determine how best to combine drugs that inhibit HER2 and AKT in HER2(+) breast cancers. We accomplished this by measuring cellular and molecular responses to lapatinib and the AKT inhibitors
Externí odkaz:
https://doaj.org/article/01e6b6cfbd714bc98c36f3440a8d060c
Publikováno v:
ELECTROPHORESIS. 43:1366-1377
Many biomedical analysis applications require trapping and manipulating single cells and cell clusters within microfluidic devices. Dielectrophoresis (DEP) is a label-free technique that can achieve flexible cell trapping, without physical barriers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07321732380db1ed2ba87bff51dd28d0
https://doi.org/10.1002/elps.202100372
https://doi.org/10.1002/elps.202100372
Time-lapse imaging is a powerful approach to gain insight into the dynamic responses of cells, but the quantitative analysis of morphological changes over time is a challenge. Here, we exploit the concept of "trajectory embedding" to analyze cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::067060fb3280d84c573fcf81fc099c0c
https://doi.org/10.21203/rs.3.rs-2347203/v1
https://doi.org/10.21203/rs.3.rs-2347203/v1
Autor:
Andrew Schultz, Saeed Alahmari, Joeseph Johnson, Thomas Veith, Zaid Siddiqui, Issam El Naqa, Laura Heiser, Noemi Andor
Publikováno v:
2022 IEEE Eighth International Conference on Big Data Computing Service and Applications (BigDataService).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0ad7efd85e03035c101fa50d8fb0317
https://doi.org/10.1109/bigdataservice55688.2022.00026
https://doi.org/10.1109/bigdataservice55688.2022.00026
Publikováno v:
ELECTROPHORESIS. 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9dfe6e022f466770fd0f0239b231e06
https://doi.org/10.1002/elps.202270071
https://doi.org/10.1002/elps.202270071
Autor:
Dylan Blumberg, Sebastian W. Ahn, Gordon B. Mills, Joe W. Gray, Oliver Jonas, Zuzana Tatarova, Pepper Schedin, James E. Korkola, John Muschler, Laura Heiser, Lisa M. Coussens
Systematically identifying synergistic combinations between targeted agents and immunotherapies in cancer based on genomic or other static biomarkers remains elusive. Here we integrate two novel high-content and high-throughput techniques, an implant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::132191dfe6fdf43011bcd1be2a768334
https://doi.org/10.21203/rs.3.rs-1054728/v1
https://doi.org/10.21203/rs.3.rs-1054728/v1