Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Laura Hautala"'
Autor:
Tuomas Aleksi Tolvanen, Jette-Britt Naams, Kristiina Wähälä, Mika Erik Anthon Berg, Sanna Lehtonen, Jari Ahonen, Laura Hautala
Publikováno v:
ACS Omega, Vol 5, Iss 3, Pp 1430-1438 (2020)
ACS Omega
ACS Omega
A series of substituted sulfonanilide analogs were prepared and evaluated as novel potent inhibitors of SH2 domaincontaining inositol polyphosphate 5′-phosphatase 2 (SHIP2). SHIP2 has been shown to be a new attractive target for the treatment of in
Autor:
Sonja Lindfors, Mervi Van, Per-Henrik Groop, Jukka Tienari, Tuomas Aleksi Tolvanen, Mika Erik Anthon Berg, Sanna Lehtonen, Vincent Dumont, Tuomas Mirtti, Hong Wang, Surjya Narayan Dash, Harry Nisen, Laura Hautala, Kristiina Wähälä, Jette-Britt Naams, Zydrune Polianskyte-Prause
Publikováno v:
The FASEB Journal
Metformin, the first-line drug to treat type 2 diabetes (T2D), inhibits mitochondrial glycerolphosphate dehydrogenase in the liver to suppress gluconeogenesis. However, the direct target and the underlying mechanisms by which metformin increases gluc
Autor:
Annukka Pasanen, Anne Dell, Cheuk-Lun Lee, Laura Hautala, Aristotelis Antonopoulos, Mikko Loukovaara, Stuart M. Haslam, Poh-Choo Pang, Hannu Koistinen, William S.B. Yeung, Ralf Bützow, Philip C.N. Chiu
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Glycodelin is a major glycoprotein expressed in reproductive tissues, like secretory and decidualized endometrium. It has several reproduction related functions that are dependent on specific glycosylation, but it has also been found to drive differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d5a923d6d3b4264859bbbd3b6c2389
http://hdl.handle.net/10044/1/78020
http://hdl.handle.net/10044/1/78020
Autor:
Ulf-Håkan Stenman, Kati Räsänen, Hannu Koistinen, Elina Lehtinen, Teijo Kuopio, Kristiina Nokelainen, Outi Itkonen, Laura Hautala
Publikováno v:
Molecular Carcinogenesis. 55:2010-2023
Inflammation promotes colorectal cancer (CRC) tumorigenesis, but the underlying molecular mechanisms are still being uncovered. Proinflammatory cytokine interleukin-6 (IL-6) stimulates survival signaling in CRC; inflammatory signals also regulate pro
Publikováno v:
Molecular Endocrinology. 29:1787-1791
Recently, several LH/human chorionic gonadotropin (hCG) receptor-independent activities for hCG have been described, including activation of the TGF-β receptor (TGFβR) by hyperglycosylated hCG and stimulation of trophoblast invasion. Because the hC
Glycodelin is a glycoprotein mainly expressed in well-differentiated epithelial cells in reproductive tissues. In normal secretory endometrium, the expression of glycodelin is abundant and regulated by progesterone. In hormone-related cancers glycode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a89be6891e680d2690824ac962e0594
http://hdl.handle.net/10138/225038
http://hdl.handle.net/10138/225038
Autor:
William S.B. Yeung, Philip C.N. Chiu, Laura Hautala, Tuula Salo, Cheuk-Lun Lee, Ulf-Håkan Stenman, Hannu Koistinen
Publikováno v:
Molecular and Cellular Endocrinology. 375:43-52
Both paracrine and autocrine factors are involved in the regulation of trophoblast invasion. One of these factors is human chorionic gonadotropin (hCG), which stimulates trophoblast invasion. The stimulatory activity has especially been ascribed to a
Autor:
Päivi Heikkilä, Riitta Koistinen, Heli Nevanlinna, Tuomas Heikkinen, Hannu Koistinen, Laura Hautala, Kristiina Aittomäki, Dario Greco, Carl Blomqvist
Publikováno v:
Breast Cancer Research and Treatment. 128:85-95
Glycodelin (encoded by PAEP gene) is a secreted lipocalin protein mainly expressed in reproductive tissues, but also in several tumour types. In the breast, glycodelin is expressed both in normal epithelial and cancerous tissue. To investigate the as
Autor:
Laura Hautala, Markku Seppälä, Wsb Yeung, Philip C.N. Chiu, Riitta Koistinen, Hannu Koistinen
Publikováno v:
European Journal of Endocrinology. 160:121-133
Glycodelin is an endocrine-regulated glycoprotein that has significant effects on immune cells, apoptosis, reproduction, cell adhesion, differentiation and cancer. In reproduction, glycodelin contributes to capacitation and immunoprotection of sperma
Autor:
Pirjo Laakkonen, Riitta Koistinen, Laura Hautala, Hannu Koistinen, Ulf-Håkan Stenman, Markku Seppälä
Publikováno v:
Scandinavian Journal of Clinical and Laboratory Investigation. 69:452-459
Glycodelin is a lipocalin family glycoprotein expressed mainly in reproductive tissues. It is involved in cell recognition, and its relationship with epithelial differentiation is well established. Glycodelin actually appears to drive epithelial diff