Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Laura H. Jacobson"'
Autor:
Sanjida Mir, Ryan J. Keenan, Romke Bron, Cameron J. Nowell, Catriona McLean, Leah C. Beauchamp, Laura J. Vella, Brian Dean, Daniel Hoyer, Laura H. Jacobson
Publikováno v:
Medicine in Drug Discovery, Vol 24, Iss , Pp 100202- (2024)
Hypocretin (Hcrtr, HCRTR) / orexin (OX) receptors modulate a range of neurobiological functions and are drug targets for several disorders. Mapping the distribution of receptors in the brain can inform their function and guide targeting of specific d
Externí odkaz:
https://doaj.org/article/9f4c6bbb7e4a49a9a8786c108d2f560f
Autor:
Daniel Hoyer, Laura H. Jacobson
Publikováno v:
Medicine in Drug Discovery, Vol 22, Iss , Pp 100190- (2024)
Orexin receptor antagonists are on the market or under development for the treatment of insomnia and a number of other neuropsychiatric disorders. Currently, suvorexant, lemborexant and daridorexant, three dual orexin receptor antagonists (DORAs) hav
Externí odkaz:
https://doaj.org/article/7861400ec1b04952ba2470f63c64ed20
Autor:
Natasha C. Dale, Daniel Hoyer, Laura H. Jacobson, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B). For the recepto
Externí odkaz:
https://doaj.org/article/1a03bd424f604276a66a0509a4f1b3c5
Autor:
Haihan Jiao, Laura E. Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J. Keenan, Laura H. Jacobson, Holly R. Chinnery
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alzheimer’s disease (AD). Although AD is accompanied by various ocular changes, the effects of tauopathy on the i
Externí odkaz:
https://doaj.org/article/f8b031e4e4be4a85a5101403a03da0a7
Autor:
Katherine Hopkins, Soumya Mukherjee, Dalia Ponce, Jonathan Mangum, Laura H. Jacobson, Daniel Hoyer
Publikováno v:
Medicine in Drug Discovery, Vol 11, Iss , Pp 100102- (2021)
Sleep-wakefulness is disrupted in most neurological and psychiatric disorders. Although clinical data implicate orexin (hypocretin), a crucial sleep/wake regulatory neuropeptide, in such disorders, limited sample volumes effectively prevent quantific
Externí odkaz:
https://doaj.org/article/56835c3384134d6aba6bebcbb6e72269
Autor:
Jeremy A. Metha, Maddison L. Brian, Sara Oberrauch, Samuel A. Barnes, Travis J. Featherby, Peter Bossaerts, Carsten Murawski, Daniel Hoyer, Laura H. Jacobson
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2020)
The exploration/exploitation tradeoff – pursuing a known reward vs. sampling from lesser known options in the hope of finding a better payoff – is a fundamental aspect of learning and decision making. In humans, this has been studied using multi-
Externí odkaz:
https://doaj.org/article/fd08186da914445282450c444185d68f
Publikováno v:
Neurobiology of Stress, Vol 9, Iss , Pp 176-187 (2018)
Depression is a highly prevalent psychiatric disorder, yet its etiology is not well understood. The validation of animal models is therefore a critical step towards advancing knowledge about the neurobiology of depression. Psychosocial stress has bee
Externí odkaz:
https://doaj.org/article/1ace7641c6c04fc2852ce7c0316f9b91
Autor:
Gabrielle Elizabeth Callander, Morenike eOlorunda, Dominique eMonna, Edi eSchuepbach, Daniel eLangenegger, Claudia eBetschart, Samuel eHintermann, Dirk eBehnke, Simona eCotesta, Markus eFendt, Grit eLaue, Silvio eOfner, Emmanuelle eBriard, Christine E. Gee, Daniel eHoyer, Laura H. Jacobson
Publikováno v:
Frontiers in Neuroscience, Vol 7 (2013)
Orexin receptor antagonists represent attractive targets for the development of drugs for the treatment of insomnia. Both efficacy and safety are crucial in clinical settings and thorough investigations of pharmacokinetics and pharmacodynamics can pr
Externí odkaz:
https://doaj.org/article/22f5a7607e504a74a27938b07945c9b6
Autor:
Ryan J. Keenan, Heather Daykin, Jiahui Chu, Linda Cornthwaite‐Duncan, Giancarlo Allocca, Daniel Hoyer, Laura H. Jacobson
Publikováno v:
British Journal of Pharmacology. 179:3403-3417
Transgenic mouse models of tauopathy display prominent sleep/wake disturbances which manifest primarily as a hyperarousal phenotype during the active phase, suggesting that tau pathology contributes to sleep/wake changes. However, no study has yet in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a34923746f7a44e8523ee7a7c809513
https://doi.org/10.1111/bph.15813
https://doi.org/10.1111/bph.15813
Autor:
Jean-Michel Rondeau, Heinrich Rueeger, Rainer Martin Lueoend, Laura H. Jacobson, Markus Voegtle, Rainer Machauer, Grit Laue, Philipp Holzer, Konstanze Hurth, Siem Jacob Veenstra, Matthias Staufenbiel, Marina Tintelnot-Blomley, Ulf Neumann, Mathias Frederiksen
Publikováno v:
Journal of Medicinal Chemistry. 64:4677-4696
Starting from lead compound 4, the 1,4-oxazine headgroup was optimized to improve potency and brain penetration. Focusing at the 6-position of the 5-amino-1,4-oxazine, the insertion of a Me and a CF3 group delivered an excellent pharmacological profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a0b16d3116f2d6a82dc5a3b35b580c
https://doi.org/10.1021/acs.jmedchem.0c02143
https://doi.org/10.1021/acs.jmedchem.0c02143