Výsledky vyhledávání - "Laura H. A. Watkins"

Impaired dimensional selection but intact use of reward feedback during visual discrimination learning in Parkinson's disease

Autor: Barbara J. Sahakian, Rachel Swainson, Teena Shetty, B. A. Summers, Laura H. A. Watkins, Trevor W. Robbins, Roger A. Barker, Charles E. Polkey, Devi SenGupta

Publikováno v: Neuropsychologia. 44:1290-1304

It has been suggested that Parkinson's disease (PD) impairs the ability to learn on the basis of reward or reinforcing feedback i.e., by trial-and-error. In many learning tasks, particular 'dimensions' of stimulus information are relevant whilst othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49018333ebe874db7c32087cf583e7f
https://doi.org/10.1016/j.neuropsychologia.2006.01.028

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Visual object and visuospatial cognition in Huntington's disease: implications for information processing in corticostriatal circuits

Autor: John R. Hodges, Barbara J. Sahakian, Laura H. A. Watkins, Trevor W. Robbins, Andrew D. Lawrence

Publikováno v: Brain. 123:1349-1364

The primate visual system contains two major streams of visual information processing. The ventral stream is directed into the inferior temporal cortex and is concerned with visual object cognition, whereas the dorsal stream is directed into the post

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b73dc2a58cf6e1fb4ae51ab8af392b7
https://doi.org/10.1093/brain/123.7.1349

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Huntington's disease progression

Autor: Barbara J. Sahakian, N. Turjanski, Robert A. Weeks, David J. Brooks, Thomasin C. Andrews, Laura H. A. Watkins, Roger N. Gunn, John R. Hodges, Nicholas W. Wood, Anne Elizabeth Rosser

Publikováno v: Brain. 122:2353-2363

Using serial [(11)C]SCH 23390- and [11C]raclopride-PET, we have measured the rate of loss of striatal dopamine D1 and D2 receptor binding over a mean of 40 months in nine asymptomatic adult Huntington's disease mutation carriers, four patients with s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e22073ab1b95dd9fc304fd21b258b95f
https://doi.org/10.1093/brain/122.12.2353

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Executive function in Tourette's syndrome and obsessive-compulsive disorder

Autor: Trevor W. Robbins, Michael R. F. Aitken, Mary M. Robertson, Laura H. A. Watkins, Kathryn M Pickard, Barbara J. Sahakian, Robert D. Rogers, David Veale

Publikováno v: Watkins, L H, Sahakian, B J, Robertson, M M, Veale, D M, Rogers, R D, Pickard, K M, Aitken, M R F & Robbins, T W 2005, ' Executive function in Tourette's syndrome and obsessive-compulsive disorder ', Psychological Medicine, vol. 35, no. 4, pp. 571-582 . https://doi.org/10.1017/S0033291704003691

Background. Cognitive performance was compared in the genetically and neurobiologically related disorders of Tourette's syndrome (TS) and obsessive–compulsive disorder (OCD), in three domains of executive function: planning, decision-making and inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c75ac4d6c1c738d02870ce713d26b1
https://pubmed.ncbi.nlm.nih.gov/15856727

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Impaired planning but intact decision making in early Huntington's disease: implications for specific fronto-striatal pathology

Autor: Barbara J. Sahakian, Anne Elizabeth Rosser, Andrew D. Lawrence, Trevor W. Robbins, Laura H. A. Watkins, Robert D. Rogers

Publikováno v: Neuropsychologia. 38(8)

Previous neuropsychological data have suggested that deficits in early Huntington's disease (HD) include executive impairments, which often are linked with frontal-lobe dysfunction. This study sought to investigate the profile of cognitive deficits u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b297becea47ad39d06ab9f6246562b7b
http://ora.ox.ac.uk/objects/uuid:a439de1a-2d67-49e1-8d07-e4b6897b1b14

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The relationship between striatal dopamine receptor binding and cognitive performance in Huntington's disease

Autor: Barbara J. Sahakian, A. E. Harding, David J. Brooks, Laura H. A. Watkins, Trevor W. Robbins, Andrew D. Lawrence, Thomasin C. Andrews, R. A. Weeks

Publikováno v: Brain : a journal of neurology. 121

Seventeen individuals at risk for Huntington's disease and five symptomatic patients, who had previously undergone [11C]SCH23390 and [11C]raclopride PET to assess in vivo levels of striatal dopamine D1 and D2 receptor binding, had neuropsychological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e5caad57ae43c58f6ba9b6193abafbd
https://pubmed.ncbi.nlm.nih.gov/9679785

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