Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Laura H Jacobson"'
Autor:
Ulf Neumann, Mike Ufer, Laura H Jacobson, Marie‐Laure Rouzade‐Dominguez, Gunilla Huledal, Carine Kolly, Rainer M Lüönd, Rainer Machauer, Siem J Veenstra, Konstanze Hurth, Heinrich Rueeger, Marina Tintelnot‐Blomley, Matthias Staufenbiel, Derya R Shimshek, Ludovic Perrot, Wilfried Frieauff, Valerie Dubost, Hilmar Schiller, Barbara Vogg, Karen Beltz, Alexandre Avrameas, Sandrine Kretz, Nicole Pezous, Jean‐Michel Rondeau, Nicolau Beckmann, Andreas Hartmann, Stefan Vormfelde, Olivier J David, Bruno Galli, Rita Ramos, Ana Graf, Cristina Lopez Lopez
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-18 (2018)
Abstract The beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE‐1) initiates the generation of amyloid‐β (Aβ), and the amyloid cascade leading to amyloid plaque deposition, neurodegeneration, and dementia in Alzheimer's disease (AD
Externí odkaz:
https://doaj.org/article/48fbf5e81f1a4f18ae40665093c63175
Autor:
Sanjida Mir, Ryan J. Keenan, Romke Bron, Cameron J. Nowell, Catriona McLean, Leah C. Beauchamp, Laura J. Vella, Brian Dean, Daniel Hoyer, Laura H. Jacobson
Publikováno v:
Medicine in Drug Discovery, Vol 24, Iss , Pp 100202- (2024)
Hypocretin (Hcrtr, HCRTR) / orexin (OX) receptors modulate a range of neurobiological functions and are drug targets for several disorders. Mapping the distribution of receptors in the brain can inform their function and guide targeting of specific d
Externí odkaz:
https://doaj.org/article/9f4c6bbb7e4a49a9a8786c108d2f560f
Autor:
Daniel eHoyer, Thomas eDürst, Markus eFendt, Laura H Jacobson, Claudia eBetschart, Samuel eHintermann, Dirk eBehnke, Simona eCotesta, Grit eLaue, Silvio eOfner, Eric eLegangneux, Christine E Gee
Publikováno v:
Frontiers in Neuroscience, Vol 7 (2013)
Dual orexin receptor (OXR) antagonists (DORAs) such as almorexant, SB-649868, suvorexant (MK-4305) and filorexant (MK-6096), have shown promise for the treatment of insomnias and sleep disorders. Whether antagonism of both OX1R and OX2R is necessary
Externí odkaz:
https://doaj.org/article/83dd9405703d4245af02f4011cce40ee
Autor:
Daniel Hoyer, Laura H. Jacobson
Publikováno v:
Medicine in Drug Discovery, Vol 22, Iss , Pp 100190- (2024)
Orexin receptor antagonists are on the market or under development for the treatment of insomnia and a number of other neuropsychiatric disorders. Currently, suvorexant, lemborexant and daridorexant, three dual orexin receptor antagonists (DORAs) hav
Externí odkaz:
https://doaj.org/article/7861400ec1b04952ba2470f63c64ed20
Autor:
Niklas Mattsson, Lawrence Rajendran, Henrik Zetterberg, Mikael Gustavsson, Ulf Andreasson, Maria Olsson, Gunnar Brinkmalm, Johan Lundkvist, Laura H Jacobson, Ludovic Perrot, Ulf Neumann, Herman Borghys, Marc Mercken, Deborah Dhuyvetter, Fredrik Jeppsson, Kaj Blennow, Erik Portelius
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31084 (2012)
BACE1 is a key enzyme for amyloid-β (Aβ) production, and an attractive therapeutic target in Alzheimer's disease (AD). Here we report that BACE1 inhibitors have distinct effects on neuronal Aβ metabolism, inducing a unique pattern of secreted Aβ
Externí odkaz:
https://doaj.org/article/820b53e8ca3c4c7fb2421581da40bd31
Autor:
Natasha C. Dale, Daniel Hoyer, Laura H. Jacobson, Kevin D. G. Pfleger, Elizabeth K. M. Johnstone
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The orexin system comprises two G protein-coupled receptors, OX1 and OX2 receptors (OX1R and OX2R, respectively), along with two endogenous agonists cleaved from a common precursor (prepro-orexin), orexin-A (OX-A) and orexin-B (OX-B). For the recepto
Externí odkaz:
https://doaj.org/article/1a03bd424f604276a66a0509a4f1b3c5
Autor:
Ryan J. Keenan, Heather Daykin, Jiahui Chu, Linda Cornthwaite‐Duncan, Giancarlo Allocca, Daniel Hoyer, Laura H. Jacobson
Publikováno v:
British Journal of Pharmacology. 179:3403-3417
Transgenic mouse models of tauopathy display prominent sleep/wake disturbances which manifest primarily as a hyperarousal phenotype during the active phase, suggesting that tau pathology contributes to sleep/wake changes. However, no study has yet in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a34923746f7a44e8523ee7a7c809513
https://doi.org/10.1111/bph.15813
https://doi.org/10.1111/bph.15813
Autor:
Jean-Michel Rondeau, Heinrich Rueeger, Rainer Martin Lueoend, Laura H. Jacobson, Markus Voegtle, Rainer Machauer, Grit Laue, Philipp Holzer, Konstanze Hurth, Siem Jacob Veenstra, Matthias Staufenbiel, Marina Tintelnot-Blomley, Ulf Neumann, Mathias Frederiksen
Publikováno v:
Journal of Medicinal Chemistry. 64:4677-4696
Starting from lead compound 4, the 1,4-oxazine headgroup was optimized to improve potency and brain penetration. Focusing at the 6-position of the 5-amino-1,4-oxazine, the insertion of a Me and a CF3 group delivered an excellent pharmacological profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a0b16d3116f2d6a82dc5a3b35b580c
https://doi.org/10.1021/acs.jmedchem.0c02143
https://doi.org/10.1021/acs.jmedchem.0c02143
Autor:
Romke Bron, Daniel Hoyer, Ryan J. Keenan, Cameron J Nowell, Leesa M. Challis, Laura H. Jacobson, Sara Oberrauch
Publikováno v:
Journal of Alzheimer's Disease. 79:693-708
Background: Sleep/wake disturbances (e.g., insomnia and sleep fragmentation) are common in neurodegenerative disorders, especially Alzheimer’s disease (AD) and frontotemporal dementia (FTD). These symptoms are somewhat reminiscent of narcolepsy wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a213ddff5314c7e8db45905e9d29fc80
https://doi.org/10.3233/jad-201177
https://doi.org/10.3233/jad-201177
Autor:
James J Gattuso, Daniel Perkins, Simon Ruffell, Andrew J Lawrence, Daniel Hoyer, Laura H Jacobson, Christopher Timmermann, David Castle, Susan L Rossell, Luke A Downey, Broc A Pagni, Nicole L Galvão-Coelho, David Nutt, Jerome Sarris
Publikováno v:
The international journal of neuropsychopharmacology.
Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well as profound psychological and mystical experiences. A grouping of interconnected brain regions characterized by increased temporal coherence at rest have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76bbeab496cb8d3101cd4b6bb580229
https://pubmed.ncbi.nlm.nih.gov/36272145
https://pubmed.ncbi.nlm.nih.gov/36272145