Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor

Autor: Claudia Mugnaini, Magdalena Kostrzewa, Marta Casini, Poulami Kumar, Valeria Catallo, Marco Allarà, Laura Guastaferro, Antonella Brizzi, Marco Paolino, Andrea Tafi, Christelos Kapatais, Gianluca Giorgi, Federica Vacondio, Marco Mor, Federico Corelli, Alessia Ligresti

Publikováno v: Molecules, Vol 28, Iss 13, p 4958 (2023)

Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide derivatives were shown to act at the CB2

Externí odkaz: https://doaj.org/article/1a82bb1f8bab4fb8bc8f13d08c4c3492

Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3- b ]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.

Autor: Mugnaini, Claudia¹ (AUTHOR) marta.casini94@gmail.com, Kostrzewa, Magdalena² (AUTHOR) m.kostrzewka@gmail.com, Casini, Marta¹ (AUTHOR) valeriacatallo@gmail.com, Kumar, Poulami² (AUTHOR) p.kumar@icb.cnr.it, Catallo, Valeria¹ (AUTHOR) guastaferro.laura@gmail.com, Allarà, Marco² (AUTHOR) mallara@icb.cnr.it, Guastaferro, Laura¹ (AUTHOR) antonella.brizzi@unisi.it, Brizzi, Antonella¹ (AUTHOR) paolino3@unisi.it, Paolino, Marco¹ (AUTHOR) andrea.tafi@unisi.it, Tafi, Andrea¹ (AUTHOR) kapatais@student.unisi.it, Kapatais, Christelos¹ (AUTHOR) gianluca.giorgi@unisi.it, Giorgi, Gianluca¹ (AUTHOR) federico.corelli@unisi.it, Vacondio, Federica³ (AUTHOR) federica.vacondio@unipr.it, Mor, Marco³ (AUTHOR) marco.mor@unipr.it, Corelli, Federico¹ (AUTHOR), Ligresti, Alessia² (AUTHOR) claudia.mugnaini@unisi.it

Publikováno v: Molecules. Jul2023, Vol. 28 Issue 13, p4958. 29p.