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Publikováno v:
BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Background Alpha1-antitrypsin (AAT) is a serine protease inhibitor that serves as a counterbalance to the activity of elastases, e.g., neutrophil elastase in lung tissue. AAT deficiency (AATD) is a rare disorder usually arising from mutation
Externí odkaz:
https://doaj.org/article/184eac18ce0a4231a243c969e954a6f8
Autor:
Begoña, Fernández-Pastor, Jorge E, Ortega, Laura, Grandoso, Elena, Castro, Luisa, Ugedo, Ángel, Pazos, J Javier, Meana
Publikováno v:
Neuropharmacology. 114
Selective serotonin reuptake inhibitors (SSRIs) regulate brain noradrenergic neurotransmission both at somatodendritic and nerve terminal areas. Previous studies have demonstrated that noradrenaline (NA) reuptake inhibitors are able to desensitize α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6833baeb724ba96009db3dc436117877
https://pubmed.ncbi.nlm.nih.gov/27908769
https://pubmed.ncbi.nlm.nih.gov/27908769
Autor:
Diego Tejedor, Estibaliz Olano-Martin, Lourdes Palacios, Antonio Martínez, Laura Grandoso, Nerea Cuevas, Marianne Stef
Publikováno v:
Atherosclerosis. 221:137-142
Familial hypercholesterolemia (FH), characterized by isolated elevation of plasmatic low-density lipoprotein (LDL) cholesterol and premature coronary heart disease (CHD), is associated with mutations in three major genes: LDL receptor ( LDLR) , apoli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10716f3eee7c14b84b6e1dc568f45915
https://doi.org/10.1016/j.atherosclerosis.2011.12.021
https://doi.org/10.1016/j.atherosclerosis.2011.12.021
Autor:
Luisa Ugedo, Laura Grandoso, Gorka Orive, Alicia Rodríguez, Iván Manuel, Mercedes Zumárraga, Isabel Ulibarri, José Ángel Ruiz-Ortega, Gurutz Linazasoro, Aurora Arrúe, Rafael Rodríguez-Puertas, José Luis Pedraz, Rosa Maria Hernandez, Sara Ponce
Publikováno v:
International Journal of Pharmaceutics. 343:69-78
Several findings suggest that glial cell line-derived neurotrophic factor (GDNF) may be a useful tool to treat parkinsonism by acting as a neuroprotective and neurotrophic factor for dopaminergic neurotransmission systems. In the present study, we im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8e52cc12d580befb825230dd92e3c8
https://doi.org/10.1016/j.ijpharm.2007.05.027
https://doi.org/10.1016/j.ijpharm.2007.05.027
Publikováno v:
Journal of Pharmacy and Pharmacology. 58:367-373
The aim of this study was to investigate the effect of citalopram, a selective serotonin reuptake inhibitor, on the sensitivity of rat vas deferens α2-adrenoceptors and to compare it with the effects of serotonin and the dual noradrenaline-serotonin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49100d8ce0f87ed453c337cd1eff2b98
https://doi.org/10.1211/jpp.58.3.0011
https://doi.org/10.1211/jpp.58.3.0011
Publikováno v:
European Journal of Pharmacology. 517:51-58
The aim of the present study was to investigate the modulation of locus coeruleus neurons by the selective serotonin (5-HT) reuptake inhibitor citalopram using single-unit extracellular recordings in rat brain slices. Citalopram inhibited the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347f4b2e5ce6c2c99c1265f1bde21c60
https://doi.org/10.1016/j.ejphar.2005.05.033
https://doi.org/10.1016/j.ejphar.2005.05.033
Publikováno v:
The international journal of neuropsychopharmacology. 14(2)
In addition to noradrenergic and serotonergic systems, dopaminergic neurotransmission seems to play an important role in the aetiopathogenesis of, and recovery from, depression. Moreover, the incidence of depression is higher in patients affected by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09f317d0f84ce7ebde86445518f2bae
https://pubmed.ncbi.nlm.nih.gov/20426885
https://pubmed.ncbi.nlm.nih.gov/20426885
Autor:
Magí Farré, Estibaliz Olano-Martin, Elisabet Cuyàs, Lorena Hernández, Laia Jofre-Monseny, Diego Tejedor, Laura Grandoso, Rafael de la Torre, Olha Khymenets, Antonio Martínez
Publikováno v:
Pharmacogenomics. 11(2)
Aims: Differences in adverse drug reactions can be explained by genetic variations, especially if they determine the expression of certain protein effectors and/or drug-metabolizing enzymes. Over the last decade, several tests screening for the most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2accb3f1f304a1bb108a057f7600fa79
https://pubmed.ncbi.nlm.nih.gov/20136364
https://pubmed.ncbi.nlm.nih.gov/20136364
Publikováno v:
Neuropharmacology. 46(6)
Several studies have suggested that the locus coeruleus may play an important role in the pathophysiology of depression. The aim of this study was to characterize, using single-unit extracellular recordings, the in vitro effects of the noradrenaline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62c93fd7ea4c4b7ae890a780a86c635
https://pubmed.ncbi.nlm.nih.gov/15033341
https://pubmed.ncbi.nlm.nih.gov/15033341