Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Laura González-Cofrade"'
Autor:
Laura González-Cofrade, Irene Cuadrado, Ángel Amesty, Ana Estévez-Braun, Beatriz de las Heras, Sonsoles Hortelano
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 825 (2022)
Dehydroisohispanolone (DIH), is a labdane diterpene that has exhibited anti-inflammatory activity via inhibition of NF-κB activation, although its potential effects on inflammasome activation remain unexplored. This study aims to elucidate whether D
Externí odkaz:
https://doaj.org/article/e0ab4264f31146f6a59f17500a580502
Autor:
Pedro Martín-Acosta, Irene Cuadrado, Laura González-Cofrade, Roberto Pestano, Sonsoles Hortelano, Beatriz de las Heras, Ana Estévez-Braun
Publikováno v:
Journal of Natural Products. 86:317-329
A set of new dihydroquinoline embelin derivatives was obtained from the reaction of the natural benzoquinone embelin (1) with anilines and aromatic aldehydes in the presence of AgOTf. The synthesis of these compounds involves the formation of a Knoev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6060745ee1fd46986c63b32f81ecd090
https://doi.org/10.1021/acs.jnatprod.2c00924
https://doi.org/10.1021/acs.jnatprod.2c00924
Autor:
Irene Cuadrado, Sandra Oramas‐Royo, Laura González‐Cofrade, Ángel Amesty, Sonsoles Hortelano, Ana Estévez‐Braun, Beatriz de las Heras
The cardiovascular side effects associated with doxorubicin (DOX), a wide spectrum anticancer drug, have limited its clinical application. Therefore, to explore novel strategies with cardioprotective effects, a series of new labdane conjugates were p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aba7157c2cbfac960f9f520fe8430cf
https://eprints.ucm.es/id/eprint/75726/
https://eprints.ucm.es/id/eprint/75726/
Autor:
Laura González-Cofrade, Jack P. Green, Irene Cuadrado, Ángel Amesty, Sandra Oramas-Royo, null David Brough, Ana Estévez-Braun, Sonsoles Hortelano, Beatriz de las Heras
Publikováno v:
Bioorganic Chemistry. 132:106362
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef85e271683409e9e684daafe762f325
https://doi.org/10.1016/j.bioorg.2023.106362
https://doi.org/10.1016/j.bioorg.2023.106362
Autor:
Sonsoles Hortelano, Laura González-Cofrade, Irene Cuadrado, Ana Estévez-Braun, Ángel Amesty, Beatriz de las Heras, Sandra Oramas-Royo
Publikováno v:
Journal of natural products. 83(7)
The NLRP3 inflammasome plays a critical role in inflammation-mediated human diseases and represents a promising drug target for novel anti-inflammatory therapies. Hispanolone is a labdane diterpenoid isolated from the aerial parts of Ballota species.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7aabce1139e76099889a5973a19c85
https://pubmed.ncbi.nlm.nih.gov/32584575
https://pubmed.ncbi.nlm.nih.gov/32584575
Publikováno v:
Planta medica. 85(17)
Natural products and their derivatives represent the most consistently successful source of drug leads. Terpenoids, a structurally diverse group, are secondary metabolites widely distributed in nature, endowed with a wide range of biological activiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9639b33a56984b495f8a6850fea2477
https://pubmed.ncbi.nlm.nih.gov/31234214
https://pubmed.ncbi.nlm.nih.gov/31234214
Publikováno v:
Dianas. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ca97daef38b495be4df3f0337e2d9f1
https://doi.org/10.37536/dianas.2019.8.1.43
https://doi.org/10.37536/dianas.2019.8.1.43
Publikováno v:
Biochemical Pharmacology. 172:113739
Increasing evidence supports NLRP3 inflammasome as a new target to control inflammation. Dysregulation of NLRP3 inflammasome has been reported to be involved in the pathogenesis of several human inflammatory diseases. However, no NLRP3 inflammasome i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7100cc36f75eee58b134d094ef377f
https://doi.org/10.1016/j.bcp.2019.113739
https://doi.org/10.1016/j.bcp.2019.113739