Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Laura Gomba"'
Autor:
Travis K. Warren, Christopher D. Kane, Jay Wells, Kelly S. Stuthman, Sean A. Van Tongeren, Nicole L. Garza, Ginger Donnelly, Jesse Steffens, Laura Gomba, Jessica M. Weidner, Sarah Norris, Xiankun Zeng, Roy Bannister, Tomas Cihlar, Sina Bavari, Danielle P. Porter, Patrick L. Iversen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory l
Externí odkaz:
https://doaj.org/article/8b24a8ac056941f5a1d728fbbaf1db9c
Autor:
Travis Warren, Elizabeth Zumbrun, Jessica M. Weidner, Laura Gomba, Franco Rossi, Roy Bannister, Jacqueline Tarrant, Matthew Reed, Eric Lee, Jo Lynne Raymond, Jay Wells, Joshua Shamblin, Kelly Wetzel, Ginger Donnelly, Sean Van Tongeren, Nicole Lackemeyer, Jesse Steffens, Adrienne Kimmel, Carly Garvey, Holly Bloomfield, Christiana Blair, Bali Singh, Sina Bavari, Tomas Cihlar, Danielle Porter
Publikováno v:
Viruses, Vol 12, Iss 1, p 92 (2020)
Recent Ebola virus (EBOV) outbreaks in West Africa and the Democratic Republic of the Congo have highlighted the urgent need for approval of medical countermeasures for treatment and prevention of EBOV disease (EVD). Until recently, when successes we
Externí odkaz:
https://doaj.org/article/42a5e1bfb28548e7ad26abcaac8bc9f5
Autor:
Alicia M. Moreau, Robert Jordan, Roy Bannister, Christiana Blair, Jesse T. Steffens, Nicole L. Garza, Laura Gomba, Jay Wells, Jessica M. Weidner, Danielle P. Porter, Travis K. Warren, Ginger Donnelly, Tomas Cihlar, Eric Lee, Sean A. Van Tongeren, Jeremy J. Bearss, Kelly S. Wetzel, Sina Bavari
Publikováno v:
The Journal of Infectious Diseases. 222:1894-1901
Marburg virus (MARV) is a filovirus with documented human case-fatality rates of up to 90%. Here, we evaluated the therapeutic efficacy of remdesivir (GS-5734) in nonhuman primates experimentally infected with MARV. Beginning 4 or 5 days post inocula
Autor:
Kelly S. Stuthman, Jessica M. Weidner, Christopher D. Kane, Nicole L. Garza, Jesse T. Steffens, Ginger Donnelly, Danielle P. Porter, Roy Bannister, Xiankun Zeng, Sina Bavari, Jay Wells, Sarah L. Norris, Patrick L. Iversen, Travis K. Warren, Laura Gomba, Sean A. Van Tongeren, Tomas Cihlar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Efficacious therapeutics for Ebola virus disease are in great demand. Ebola virus infections mediated by mucosal exposure, and aerosolization in particular, present a novel challenge due to nontypical massive early infection of respiratory lymphoid t
Autor:
Christiana Blair, Roy Bannister, Sina Bavari, Jacqueline Tarrant, Matthew C. Reed, Ginger Donnelly, Joshua D. Shamblin, Adrienne E. Kimmel, Travis K. Warren, Laura Gomba, Kelly S. Wetzel, Sean A. Van Tongeren, Jesse T. Steffens, Jessica M. Weidner, Tomas Cihlar, Nicole Lackemeyer, Franco Rossi, Jay Wells, Elizabeth E. Zumbrun, Bali Singh, Danielle P. Porter, Holly A. Bloomfield, Eric Lee, Carly Garvey, Jo Lynne Raymond
Publikováno v:
Viruses, Vol 12, Iss 1, p 92 (2020)
Viruses
Volume 12
Issue 1
Viruses
Volume 12
Issue 1
Recent Ebola virus (EBOV) outbreaks in West Africa and the Democratic Republic of the Congo have highlighted the urgent need for approval of medical countermeasures for treatment and prevention of EBOV disease (EVD). Until recently, when successes we
Autor:
Stuart T. Nichol, Brett P. Eaton, Nate Larson, Ginger Donnelly, Mike Flint, Robert Jordan, Douglas L. Mayers, Michel Perron, Yeojin Park, Dustin Siegel, Lydia Wolfe, Veronica Soloveva, Edward Doerffler, William A. Lee, Donald K. Nichols, Dima N. Gharaibeh, Elizabeth C. Grimes, Laura Gomba, Darius Babusis, Travis K. Warren, Kwon Soo Chun, Tomas Cihlar, Queenie Wang, Adrian S. Ray, Kirsten M. Stray, Bruce Ross, Elyse R. Nagle, Kelly S. Stuthman, Lisa S. Welch, Rachel Fearns, Jonathan E. Nuss, Willard Lew, Jeffrey R. Kugelman, Molly R. Braun, Roy Bannister, Richard L. Mackman, Pamela Wong, Christina F. Spiropoulou, Joy Y. Feng, Hui Hon Chung, Ona Barauskas, Sean Neville, Jay Wells, Robert G. Strickley, Catherine L. Wilhelmsen, S. Swaminathan, Iva Trancheva, Nicole L. Garza, Cary Retterer, Michael K. Lo, Sean A. Van Tongeren, Gustavo Palacios, Laura K. McMullan, Amy C. Shurtleff, Lijun Zhang, Michael O. Clarke, Yili Xu, Sina Bavari, Tara Kenny, Ernest Carra, Rouzbeh Zamani, Shan Shan Chen
Publikováno v:
Nature
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agen
Autor:
Richard J. Sciotti, Milica Videnović, Dejan Opsenica, Mario Zlatović, Maja Krstic, Jonathan E. Nuss, Sandra Šegan, Sina Bavari, Života Selaković, Bogdan A. Šolaja, Jelena Konstantinović, Laura Gomba, James C. Burnett
Publikováno v:
Journal of Medicinal Chemistry
Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain were synthesized. Introducing an amino group at the C(3) position of the cholate component ma
Autor:
Milena Mitrić, Mikloš Tot, James C. Burnett, Dejan Opsenica, Bogdan A. Šolaja, Sina Bavari, Laura Gomba
Publikováno v:
Journal of the Serbian Chemical Society, Vol 78, Iss 12, Pp 1847-1864 (2013)
Steroidal and adamantane aminoacridine derivatives were prepared and tested as both botulinum neurotoxin (BoNT) inhibitors and antimalarials. Steroid-bound acridines provided good potency against both the BoNT/A and BoNT/B light chains (LCs). The obs
Autor:
Veronica Soloveva, Adrian S. Ray, Stuart T. Nichol, Robert Jordan, Joy Y. Feng, Iva Trantcheva, Jessica M. Weidner, Richard L. Mackman, Amy C. Sims, Alison Hogg, Travis K. Warren, Ralph S. Baric, H. Feldmann, Christina F. Spiropoulou, Laura Gomba, Emmie de Wit, Roy Bannister, Dustin Siegel, Tomas Cihlar, Darius Babusis, Michael K. Lo, Sina Bavari, Friederike Feldmann, Danielle Porter-Poulin, Mark R. Denison, Adam S. Cockrell, Timothy P. Sheahan, Jacqueline Cronin
Publikováno v:
Open Forum Infectious Diseases
Background Recent viral outbreaks with significant mortality such as Ebola virus (EBOV), SARS-coronavirus (CoV), and MERS-CoV reinforced the need for effective antiviral therapeutics to control future epidemics. GS-5734 is a novel nucleotide analog p
Autor:
Mikloš Tot, James C. Burnett, Richard J. Sciotti, Bogdan A. Šolaja, Sina Bavari, Igor Opsenica, Jonathan E. Nuss, Laura Gomba
Publikováno v:
Journal of Medicinal Chemistry
Structurally simplified analogues of dual antimalarial and botulinum neurotoxin serotype A light chain (BoNT/A LC) inhibitor bis-aminoquinoline (1) were prepared. New compounds were designed to improve ligand efficiency while maintaining or exceeding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0e00d2fc37038aaf71093e3b4249bb
https://cherry.chem.bg.ac.rs/handle/123456789/1381
https://cherry.chem.bg.ac.rs/handle/123456789/1381