Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Laura Garuti"'
The diaryl urea is an important fragment/pharmacophore in constructing anticancer molecules due to its near-perfect binding with certain acceptors. The urea NH moiety is a favorable hydrogen bond donor, while the urea oxygen atom is regarded as an ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2668ab59839340d41d2b50826110f3b3
https://hdl.handle.net/11576/2688396
https://hdl.handle.net/11576/2688396
Publikováno v:
Current Medicinal Chemistry. 19:3937-3948
Polo-like kinases (PLKs) are a family of serine/threonine kinases that play crucial roles in multiple stages of mitosis. PLK1 is the most studied member of the family. It is overexpressed in a wide spectrum of cancer types and is a promising target i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107e87230f1c12cd917db61529a6ab15
https://doi.org/10.2174/092986712802002455
https://doi.org/10.2174/092986712802002455
Publikováno v:
Current Medicinal Chemistry. 17:2804-2821
Protein kinases represent an attractive target in oncology drug discovery. Most of kinase inhibitors are ATP-competitive and are called type I inhibitors. The ATP-binding pocket is highly conserved among members of the kinase family and it is difficu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be02eb88ae5ad9e981e8d5013906015b
https://doi.org/10.2174/092986710791859333
https://doi.org/10.2174/092986710791859333
Publikováno v:
Current medicinal chemistry. 22(6)
none 3 no The limitations of many mono-kinase inhibitors can be overcome by agents with multi-target action. An important advantage of targeting more than one kinase, is an increase in potency, due to the synergistic effect. Moreover, this approach c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26d0c208695a04914b8e9de2bc3be52f
https://pubmed.ncbi.nlm.nih.gov/25511779
https://pubmed.ncbi.nlm.nih.gov/25511779
Autor:
Laura Garuti, Giorgio Cantelli-Forti, Benedetta Brighenti, Francesca Maffei, Carmela Fimognari, Patrizia Hrelia, Silvia Burnelli
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 397:293-301
A new series of 4-nitro-(imidazoles and pyrazoles) were synthesized as novel antimycotics and tested for their activation to mutagenic forms using Salmonella typhimurium TA98 and TA100, in the presence and in the absence of metabolic activation. TA10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7caa9c7cd53d455c3de0c3e24da7b7
https://doi.org/10.1016/s0027-5107(97)00229-7
https://doi.org/10.1016/s0027-5107(97)00229-7
Publikováno v:
European Journal of Medicinal Chemistry. 33:43-46
Some 3-substituted indole-triazin-4-ones were synthesized. Their antiproliferative activity against chronic myeloid leukaemia and non-Hodgkin lymphoma human cells was compared in vitro with that of daunorubicin. One compound appeared to be very effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2328de20780fd81fc936b6b02841db47
https://doi.org/10.1016/s0223-5234(99)80074-9
https://doi.org/10.1016/s0223-5234(99)80074-9
Publikováno v:
Current medicinal chemistry. 21(20)
Benzimidazole is a common kinase inhibitor scaffold and benzimidazole-based compounds interact with enzymes by multiple binding modes. In some cases, the benzimidazole acts as part of the hinge-binding motif, in others it has a scaffolding role witho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eac0794705d576fb8a1f514b2b65b9d
https://pubmed.ncbi.nlm.nih.gov/24533813
https://pubmed.ncbi.nlm.nih.gov/24533813
Publikováno v:
Synthesis. 1994:1437-1440
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a23917fffee34843e2bdfc3674aef0cb
https://doi.org/10.1055/s-1994-25709
https://doi.org/10.1055/s-1994-25709
Targeting cancer with small molecule irreversible inhibitors of kinases represents an emerging challenge in drug discovery. Irreversible inhibitors bind to kinase active site in a covalent and irreversible form, most frequently by reacting with a nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d67e23b5e5ddec19f0541ac27f65bc
https://hdl.handle.net/11576/2688468
https://hdl.handle.net/11576/2688468
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79c18602388974ab2f323e83b7fdf765
https://doi.org/10.1002/chin.199121118
https://doi.org/10.1002/chin.199121118