Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Laura G Dubois"'
Autor:
Hector Alex Saka, J Will Thompson, Yi-Shan Chen, Laura G Dubois, Joel T Haas, Arthur Moseley, Raphael H Valdivia
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124630 (2015)
The obligate intracellular bacterium Chlamydia trachomatis is a major human pathogen and a main cause of genital and ocular diseases. During its intracellular cycle, C. trachomatis replicates inside a membrane-bound vacuole termed an "inclusion". Acq
Externí odkaz:
https://doaj.org/article/562ef71b62a34423b299a931d1120780
Autor:
Dianne Little, J Will Thompson, Laura G Dubois, David S Ruch, M Arthur Moseley, Farshid Guilak
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96526 (2014)
The risk of anterior cruciate ligament (ACL) injury and re-injury is greater for women than men. Among other factors, compositional differences may play a role in this differential risk. Patellar tendon (PT) autografts are commonly used during recons
Externí odkaz:
https://doaj.org/article/5ab608277eaa4bcf9e39e05c2b8efc4f
Autor:
Julia R. Palmucci, Blake E. Sells, Charles D. Giamberardino, Dena L. Toffaletti, Baodi Dai, Yohannes G. Asfaw, Laura G. Dubois, Zhong Li, Barbara Theriot, Wiley A. Schell, William Hope, Jennifer L. Tenor, John R. Perfect
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTInvasive fungal infections are a significant public health concern, with mortality rates ranging from 20% to 85% despite current treatments. Therefore, we examined whether a ketogenic diet could serve as a successful treatment intervention in
Externí odkaz:
https://doaj.org/article/1c4d26c9463d44078161728fc5c59925
Autor:
Charles D. Giamberardino, Wiley A. Schell, Jennifer L. Tenor, Dena L. Toffaletti, Julia R. Palmucci, Choiselle Marius, Jane-Valeriane K. Boua, Quinlyn Soltow, Robert Mansbach, M. Arthur Moseley, J. Will Thompson, Laura G. Dubois, William Hope, John R. Perfect, Karen Joy Shaw
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Cryptococcal Meningitis (CM) is uniformly fatal if not treated, and treatment options are limited. We previously reported on the activity of APX2096, the prodrug of the novel Gwt1 inhibitor APX2039, in a mouse model of CM. Here, we investiga
Externí odkaz:
https://doaj.org/article/12c94fc2bb48423287573f9192ce65ce
Autor:
Kevin A. Friede, Margaret M. Infeld, Ru San Tan, Holly J. Knickerbocker, Rachel A. Myers, Laura G. Dubois, J. Will Thompson, Rima Kaddurah‐Daouk, Geoffrey S. Ginsburg, Thomas L. Ortel, Deepak Voora
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 14 (2020)
Background There are sex differences in the efficacy and safety of aspirin for the prevention of myocardial infarction and stroke. Whether this is explained by underlying differences in platelet reactivity and aspirin response remains poorly understo
Externí odkaz:
https://doaj.org/article/dd149699ca50412cae2156f95b0d1986
Autor:
Amy E. Baek, Yen-Rei A. Yu, Sisi He, Suzanne E. Wardell, Ching-Yi Chang, Sanghoon Kwon, Ruchita V. Pillai, Hannah B. McDowell, J. Will Thompson, Laura G. Dubois, Patrick M. Sullivan, Jongsook K. Kemper, Michael D. Gunn, Donald P. McDonnell, Erik R. Nelson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
High cholesterol is a risk factor for breast cancer recurrence. Here the authors show that cholesterol promotes breast cancer metastasis via its metabolite 27-hydroxycholesterol (27HC) that acts on immune myeloid cells residing at the distal metastat
Externí odkaz:
https://doaj.org/article/f990d083ec9e44f8ab4139f27a94e9ba
Autor:
Michael N. Davies, Lilja Kjalarsdottir, J. Will Thompson, Laura G. Dubois, Robert D. Stevens, Olga R. Ilkayeva, M. Julia Brosnan, Timothy P. Rolph, Paul A. Grimsrud, Deborah M. Muoio
Publikováno v:
Cell Reports, Vol 14, Iss 2, Pp 243-254 (2016)
Lysine acetylation (AcK), a posttranslational modification wherein a two-carbon acetyl group binds covalently to a lysine residue, occurs prominently on mitochondrial proteins and has been linked to metabolic dysfunction. An emergent theory suggests
Externí odkaz:
https://doaj.org/article/06329eac6e5c4b7a91f3336d78485c33
Autor:
Stephen J. Freedland, Donald P. McDonnell, Jen-Tsan Chi, Ching-yi Chang, Michael R. Freeman, Laura G. Dubois, J. Will Thompson, Joseph Geradts, Everardo Macias, Jeffery S. Jasper, Rachid Safi, Wen Liu, Erik R. Nelson, Mahmoud A. Alfaqih
Reagents and cell culture conditions. Methods for bioinformatics analysis, CYP27A1 IHC, caspase assays and 27HC measurements.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad84cff098e2692dbc0e40b3061b119b
https://doi.org/10.1158/0008-5472.22416096
https://doi.org/10.1158/0008-5472.22416096
Autor:
Stephen J. Freedland, Donald P. McDonnell, Jen-Tsan Chi, Ching-yi Chang, Michael R. Freeman, Laura G. Dubois, J. Will Thompson, Joseph Geradts, Everardo Macias, Jeffery S. Jasper, Rachid Safi, Wen Liu, Erik R. Nelson, Mahmoud A. Alfaqih
Evaluation of CYP27A1 expression in PC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e1343ce1aed171505c1ec6b3c16c62
https://doi.org/10.1158/0008-5472.22416111.v1
https://doi.org/10.1158/0008-5472.22416111.v1
Autor:
Stephen J. Freedland, Donald P. McDonnell, Jen-Tsan Chi, Ching-yi Chang, Michael R. Freeman, Laura G. Dubois, J. Will Thompson, Joseph Geradts, Everardo Macias, Jeffery S. Jasper, Rachid Safi, Wen Liu, Erik R. Nelson, Mahmoud A. Alfaqih
Table S1. CYP27A1 transcript is down-regulated in primary prostate tumors. Table S2. CYP27A1 transcript is down-regulated in metastatic PC relative to primary tumors. Table S3. CYP27A1 transcript levels in hormone sensitive PC relative to hormone res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8f39fdf0429ad4220227e02ae8a090
https://doi.org/10.1158/0008-5472.22416093
https://doi.org/10.1158/0008-5472.22416093