Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laura Furstenthal"'
Publikováno v:
Nature Reviews Drug Discovery. 7:563-567
Specialty pharmaceuticals have become increasingly important in the global pharmaceutical landscape. Numerous large pharmaceutical companies are moving towards developing therapies for specialty markets, which are attractive owing to factors includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48465e22798dbeb6b0c7e9fbc2d76a52
https://doi.org/10.1038/nrd2594
https://doi.org/10.1038/nrd2594
Publikováno v:
Nature Cell Biology. 3:715-722
To ensure proper timing of the G1-S transition in the cell cycle, the cyclin E-Cdk2 complex, which is responsible for the initiation of DNA replication, is restrained by the p21(Cip1)/p27(Kip1)/p57(Kip2) family of CDK (cyclin-dependent kinase) inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e849502eec39c5d2f7080a3c24c3c3
https://doi.org/10.1038/35087026
https://doi.org/10.1038/35087026
Publikováno v:
The Journal of Cell Biology
Using an in vitro chromatin assembly assay in Xenopus egg extract, we show that cyclin E binds specifically and saturably to chromatin in three phases. In the first phase, the origin recognition complex and Cdc6 prereplication proteins, but not the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc8eb49e9b4f0054b7ac56a9425142d
https://doi.org/10.1083/jcb.152.6.1267
https://doi.org/10.1083/jcb.152.6.1267
Autor:
Peter K. Jackson, Adam G. Eldridge, Brett K. Kaiser, Julie D.R. Reimann, Jerry Y. Hsu, Laura Furstenthal, Ellen Freed
Publikováno v:
Trends in Cell Biology. 10:429-439
Recently, many new examples of E3 ubiquitin ligases or E3 enzymes have been found to regulate a host of cellular processes. These E3 enzymes direct the formation of multiubiquitin chains on specific protein substrates, and - typically - the subsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e60d4c410a6ac26c7cd1bd28ad08cb
https://doi.org/10.1016/s0962-8924(00)01834-1
https://doi.org/10.1016/s0962-8924(00)01834-1
Autor:
Jerel C, Davis, Laura, Furstenthal, Amar A, Desai, Troy, Norris, Saumya, Sutaria, Edd, Fleming, Philip, Ma
Publikováno v:
Nature reviews. Drug discovery. 8(4)
'Personalized medicine' promises to increase the quality of clinical care and, in some cases, decrease health-care costs. Despite this, only a handful of diagnostic tests have made it to market, with mixed success. Historically, the challenges in thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::963f8c2bac5785f572df6ce10f36332d
https://pubmed.ncbi.nlm.nih.gov/19300459
https://pubmed.ncbi.nlm.nih.gov/19300459
Publikováno v:
Nature reviews. Drug discovery. 7(7)
Specialty pharmaceuticals have become increasingly important in the global pharmaceutical landscape. Numerous large pharmaceutical companies are moving towards developing therapies for specialty markets, which are attractive owing to factors includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd3eafcaae989f3e97458bf780c33305
https://pubmed.ncbi.nlm.nih.gov/18535582
https://pubmed.ncbi.nlm.nih.gov/18535582