Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Laura F. Corns"'
Autor:
Laura F. Corns, Stuart L. Johnson, Terri Roberts, Kishani M. Ranatunga, Aenea Hendry, Federico Ceriani, Saaid Safieddine, Karen P. Steel, Andy Forge, Christine Petit, David N. Furness, Corné J. Kros, Walter Marcotti
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Mechanoelectrical transducer (MET) channels on the tips of inner hair cells are essential for transducing auditory sensory information. Here, the authors show that disrupting MET channel function also prevents the preservation of normal inner hair ce
Externí odkaz:
https://doaj.org/article/ecfdf3bfbfef42019680748d1efaa1ea
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
The ability of cochlear hair cells to convert sound into receptor potentials relies on the mechanoelectrical transducer (MET) channels present in their stereociliary bundles. There is strong evidence implying that transmembrane channel-like protein (
Externí odkaz:
https://doaj.org/article/bb4207df85eb4920991cb25b32850069
Autor:
Lukas Rüttiger, Stuart L. Johnson, Adam J Carlton, Kevin P. Legan, Jing-Yi Jeng, Philine Marchetta, Guy P. Richardson, Richard J. Goodyear, Laura F. Corns, Csaba Harasztosi, Walter Marcotti
Publikováno v:
The Journal of Physiology. 599:2015-2036
Key points The aim was to determine whether detachment of the tectorial membrane (TM) from the organ of Corti in Tecta/Tectb-/- mice affects the biophysical properties of cochlear outer hair cells (OHCs). Tecta/Tectb-/- mice have highly elevated hear
Autor:
Jing-Yi, Jeng, Csaba, Harasztosi, Adam J, Carlton, Laura F, Corns, Philine, Marchetta, Stuart L, Johnson, Richard J, Goodyear, Kevin P, Legan, Lukas, Rüttiger, Guy P, Richardson, Walter, Marcotti
Publikováno v:
J Physiol
The tectorial membrane (TM) is an acellular structure of the cochlea that is attached to the stereociliary bundles of the outer hair cells (OHCs), electro-motile cells that amplify motion of the cochlear partition and sharpen its frequency selectivit
Autor:
Walter Marcotti, Sarah L Boddy, Marcelo N. Rivolta, Laura F. Corns, Ricardo Romero-Guevara, Ae-Ri Ji, Christian Unger
Publikováno v:
Stem Cells International
Stem Cells International, Vol 2020 (2020)
Stem Cells International, Vol 2020 (2020)
Damage to the sensory hair cells and the spiral ganglion neurons of the cochlea leads to deafness. Induced pluripotent stem cells (iPSCs) are a promising tool to regenerate the cells in the inner ear that have been affected by pathology or have been
Autor:
Aziz El-Amraoui, Stuart L. Johnson, Christine Petit, Michelle Simon, Prashanthini Jeyarajan, Lauren Chessum, Michael R. Bowl, Sherylanne Newton, Andrea Lelli, Helena Rr Wells, Frances M K Williams, Andrew Parker, Joanne Dorning, Didier Dulon, Susan Morse, Suhasini R. Gopal, Steve D.M. Brown, Sedigheh Delmaghani, Philomena Mburu, Christopher T. Esapa, Ronna Hertzano, Sara Wells, Debbie Williams, Carlos A. Aguilar, Kumar N. Alagramam, Pranav Patni, Thibault Peineau, Walter Marcotti, Laura F. Corns, Sally J. Dawson, Gemma F. Codner, Lucy A Dunbar
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, Vol 11, Iss 9, Pp n/a-n/a (2019)
EMBO Molecular Medicine, Wiley Open Access, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, Vol 11, Iss 9, Pp n/a-n/a (2019)
International audience; Hearing relies on mechanically gated ion channels present in the actin-rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and maintenance of the soun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaae1d8c8cc8054398a9affa8ff41c6
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261798/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261798/document
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
The ability of cochlear hair cells to convert sound into receptor potentials relies on the mechanoelectrical transducer (MET) channels present in their stereociliary bundles. There is strong evidence implying that transmembrane channel-like protein (
Autor:
Laura F, Corns, Walter, Marcotti
Publikováno v:
Physiological Reports
The mechanoelectrical transducer (MET) channels located at the stereocilia tip of cochlear hair cells are crucial to convert the mechanical energy of sound into receptor potentials, but the identity of its pore‐forming subunits remains uncertain. P
Autor:
Walter, Marcotti, Laura F, Corns, Richard J, Goodyear, Agnieszka K, Rzadzinska, Karen B, Avraham, Karen P, Steel, Guy P, Richardson, Corné J, Kros
Publikováno v:
The Journal of Physiology
Key points The transduction of sound into electrical signals occurs at the hair bundles atop sensory hair cells in the cochlea, by means of mechanosensitive ion channels, the mechano‐electrical transducer (MET) channels.The MET currents decline dur
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(2)
The transduction of sound into electrical signals depends on mechanically sensitive ion channels in the stereociliary bundle. The molecular composition of this mechanoelectrical transducer (MET) channel is not yet known. Transmembrane channel-like pr