Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Laura F Dagley"'
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271025 (2022)
For bottom-up proteomic analysis, the goal of analytical pipelines that process the raw output of mass spectrometers is to detect, characterise, identify, and quantify peptides. The initial steps of detecting and characterising features in raw data m
Externí odkaz:
https://doaj.org/article/63d9ee5d4b6a44eeb133fffb910e03d0
Autor:
Jorge Luis Galeano Niño, Sophie V Pageon, Szun S Tay, Feyza Colakoglu, Daryan Kempe, Jack Hywood, Jessica K Mazalo, James Cremasco, Matt A Govendir, Laura F Dagley, Kenneth Hsu, Simone Rizzetto, Jerzy Zieba, Gregory Rice, Victoria Prior, Geraldine M O'Neill, Richard J Williams, David R Nisbet, Belinda Kramer, Andrew I Webb, Fabio Luciani, Mark N Read, Maté Biro
Publikováno v:
eLife, Vol 9 (2020)
Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coo
Externí odkaz:
https://doaj.org/article/d671480f3ae34c5f99f6cf4e7a7c2792
Autor:
Alessandro D Uboldi, Mary-Louise Wilde, Emi A McRae, Rebecca J Stewart, Laura F Dagley, Luning Yang, Nicholas J Katris, Sanduni V Hapuarachchi, Michael J Coffey, Adele M Lehane, Cyrille Y Botte, Ross F Waller, Andrew I Webb, Malcolm J McConville, Christopher J Tonkin
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2005642 (2018)
The phylum Apicomplexa comprises a group of obligate intracellular parasites that alternate between intracellular replicating stages and actively motile extracellular forms that move through tissue. Parasite cytosolic Ca2+ signalling activates motili
Externí odkaz:
https://doaj.org/article/b74ca0993f11485cab44baf31f1908a9
Autor:
Azadeh Seidi, Linden S Muellner-Wong, Esther Rajendran, Edwin T Tjhin, Laura F Dagley, Vincent YT Aw, Pierre Faou, Andrew I Webb, Christopher J Tonkin, Giel G van Dooren
Publikováno v:
eLife, Vol 7 (2018)
The mitochondrion of apicomplexan parasites is critical for parasite survival, although the full complement of proteins that localize to this organelle has not been defined. Here we undertake two independent approaches to elucidate the mitochondrial
Externí odkaz:
https://doaj.org/article/3594533da5ab4d4a81fd7f949f455500
Autor:
Swati Dawar, Mariana C. Benitez, Yoon Lim, Toby A. Dite, Jumana M. Yousef, Niko Thio, Sylvain Garciaz, Thomas D. Jackson, Julia V. Milne, Laura F. Dagley, Wayne A. Phillips, Sharad Kumar, Nicholas J. Clemons
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-12 (2024)
Abstract Caspase-2, one of the most evolutionarily conserved members of the caspase family, is an important regulator of the cellular response to oxidative stress. Given that ferroptosis is suppressed by antioxidant defense pathways, such as that inv
Externí odkaz:
https://doaj.org/article/c7b62275bdf5491087ff5cffc8820630
Autor:
Daniela Fietz, Raouda Sgaier, Liza O’Donnell, Peter G. Stanton, Laura F. Dagley, Andrew I. Webb, Hans-Christian Schuppe, Thorsten Diemer, Adrian Pilatz
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionAzoospermia, characterized by an absence of sperm in the ejaculate, represents the most severe form of male infertility. While surgical sperm retrieval in obstructive azoospermia (OA) is successful in the majority of cases, patients with
Externí odkaz:
https://doaj.org/article/05dd56e6fba143f3ae70adeae3afa88a
Autor:
Yanxiang Meng, Sarah E. Garnish, Katherine A. Davies, Katrina A. Black, Andrew P. Leis, Christopher R. Horne, Joanne M. Hildebrand, Hanadi Hoblos, Cheree Fitzgibbon, Samuel N. Young, Toby Dite, Laura F. Dagley, Aarya Venkat, Natarajan Kannan, Akiko Koide, Shohei Koide, Alisa Glukhova, Peter E. Czabotar, James M. Murphy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely implicated in human disease, including renal, pulmonary, gut and skin inflammatory pathologies. The precise mechanism of the terminal steps in the pathway
Externí odkaz:
https://doaj.org/article/3125421e28064554a4a1522779b6993c
Autor:
Tony Triglia, Stephen W. Scally, Benjamin A. Seager, Michał Pasternak, Laura F. Dagley, Alan F. Cowman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain more than 16 merozoites, which egress and invade fresh erythrocytes. The aspartic p
Externí odkaz:
https://doaj.org/article/26c55b01bd7d4a168188f7b3c4ab9d70
Autor:
Liza O’Donnell, Laura F. Dagley, Michael Curley, Annalucia Darbey, Peter J. O’Shaughnessy, Thorsten Diemer, Adrian Pilatz, Daniela Fietz, Peter G. Stanton, Lee B. Smith, Diane Rebourcet
Publikováno v:
PLoS ONE, Vol 18, Iss 9 (2023)
Sertoli cells support the development of sperm and the function of various somatic cells in the interstitium between the tubules. Sertoli cells regulate the function of the testicular vasculature and the development and function of the Leydig cells t
Externí odkaz:
https://doaj.org/article/b12856a5a9754a999cd00b7cc1ae9dd5
Autor:
Ronnie Ren Jie Low, Ka Yee Fung, Hugh Gao, Adele Preaudet, Laura F. Dagley, Jumana Yousef, Belinda Lee, Samantha J. Emery-Corbin, Paul M. Nguyen, Rune H. Larsen, Nadia J. Kershaw, Antony W. Burgess, Peter Gibbs, Frédéric Hollande, Michael D. W. Griffin, Sean M. Grimmond, Tracy L. Putoczki
Publikováno v:
Cell Death & Differentiation. 30:1155-1165
Epithelial-mesenchymal transition (EMT) is a continuum that includes epithelial, partial EMT, and mesenchymal states, each of which is associated with cancer progression, invasive capabilities, and ultimately, metastasis. We used a lineage-traced spo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35c55a081d437052aa971c8a49307aab
https://doi.org/10.1038/s41418-023-01126-z
https://doi.org/10.1038/s41418-023-01126-z