Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Laura Espino-Paisán"'
Alterations in the immune system persist after one year of convalescence in severe COVID-19 patients
Autor:
Judith Abarca-Zabalía, Adela González-Jiménez, Myriam Calle-Rubio, Andrea R. López-Pastor, Tomás Fariña, Carlos Ramos-Acosta, Eduardo Anguita, Elena Urcelay, Laura Espino-Paisán
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere COVID-19 originates a myriad of alterations in the immune system during active disease, especially in the T and NK cell compartments, but several studies in the last year have unveiled some alterations that persist in convalescence
Externí odkaz:
https://doaj.org/article/52cb2d371f2b48ec9b96909e7fd1c1b6
Autor:
Pilar López-Cotarelo, Adela González-Jiménez, Teresa Agudo-Jiménez, Judith Abarca-Zabalía, Yolanda Aladro, Belén Pilo, Manuel Comabella, Laura Espino-Paisán, Elena Urcelay
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract One of the 233 polymorphisms associated with multiple sclerosis (MS) susceptibility lies within the NDFIP1 gene, and it was previously identified as eQTL in healthy controls. NDFIP1 shows interesting immune functions and is involved in the d
Externí odkaz:
https://doaj.org/article/3f10b6410d8943f38744881654a3e221
Autor:
Carlos Oribio-Quinto, Barbara Burgos-Blasco, Pilar Pérez-García, Laura Espino-Paisán, Beatriz Sarriá, José Ignacio Fernández-Vigo, Julian García-Feijóo
Publikováno v:
Journal of Clinical Medicine, Vol 12, Iss 9, p 3142 (2023)
Background: Cytokine profile in patients with primary open-angle glaucoma (POAG) differs from that in healthy controls. Due to the different pathophysiological mechanisms involved in the genesis of primary congenital glaucoma (PCG) and POAG, it is po
Externí odkaz:
https://doaj.org/article/6a4d7bed101446d4ba91e1f71eaabc7d
Autor:
Isabel de Rojas, César Martin-Montero, Maria Fedetz, Adela González-Jiménez, Fuencisla Matesanz, Elena Urcelay, Laura Espino-Paisán
Publikováno v:
Biology, Vol 11, Iss 10, p 1417 (2022)
Disrupted circadian cycle has been reported in multiple sclerosis (MS). Previous genome-wide association studies (GWAS) singled out over 230 variants associated with MS. A study performed in a Slavic population identified two new single nucleotide po
Externí odkaz:
https://doaj.org/article/f637c1713ba643fdb33473aaadaf4972
Autor:
Adela González-Jiménez, Pilar López-Cotarelo, Teresa Agudo-Jiménez, Marisa Martínez-Ginés, Jose Manuel García-Domínguez, Elena Urcelay, Laura Espino-Paisán
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7956 (2022)
One of the multiple sclerosis (MS) risk polymorphisms, rs7923837, maps near the HHEX (hematopoietically-expressed homeobox) gene. This variant has also been associated with type 2 diabetes susceptibility and with triglyceride levels, suggesting its m
Externí odkaz:
https://doaj.org/article/1175792f353d41d3ad660cdf32128780
Autor:
Adela González-Jiménez, Pilar López-Cotarelo, Teresa Agudo-Jiménez, Ignacio Casanova, Carlos López de Silanes, Ángeles Martín-Requero, Fuencisla Matesanz, Elena Urcelay, Laura Espino-Paisán
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8116 (2022)
Deficiencies in Mannosidase β (MANBA) are associated with neurological abnormalities and recurrent infections. The single nucleotide polymorphism located in the 3′UTR of MANBA, rs7665090, was found to be associated with multiple sclerosis (MS) sus
Externí odkaz:
https://doaj.org/article/afa46f33edc84a28b972a5797ccb10d9
Autor:
Laura Espino-Paisán, Teresa Agudo-Jiménez, Isabel Rosales-Martínez, Pilar López-Cotarelo, María Ángel García-Martínez, María Inmaculada Domínguez-Mozo, Silvia Pérez-Pérez, Romina Dieli-Crimi, Manuel Comabella, Elena Urcelay, Roberto Álvarez-Lafuente
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Myelin basic protein (MBP) is thought to be one of the key autoantigens in multiple sclerosis (MS) development. A recent study described the association of the single nucleotide polymorphism (SNP) rs12959006, within the MBP gene, with a higher risk o
Externí odkaz:
https://doaj.org/article/17169dd6b60c465c92a03e6df3ba0383
Autor:
Carles Vilariño-Güell, Alexander Zimprich, Filippo Martinelli-Boneschi, Bruno Herculano, Zhe Wang, Fuencisla Matesanz, Elena Urcelay, Koen Vandenbroeck, Laura Leyva, Denis Gris, Charbel Massaad, Jacqueline A Quandt, Anthony L Traboulsee, Mary Encarnacion, Cecily Q Bernales, Jordan Follett, Irene M Yee, Maria G Criscuoli, Angela Deutschländer, Eva M Reinthaler, Tobias Zrzavy, Elisabetta Mascia, Andrea Zauli, Federica Esposito, Antonio Alcina, Guillermo Izquierdo, Laura Espino-Paisán, Jorge Mena, Alfredo Antigüedad, Patricia Urbaneja-Romero, Jesús Ortega-Pinazo, Weihong Song, A Dessa Sadovnick
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008180 (2019)
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system characterized by myelin loss and neuronal dysfunction. Although the majority of patients do not present familial aggregation, Mendelian forms have been described. We per
Externí odkaz:
https://doaj.org/article/3aec66c42d53419dadaeb628391f9fea
Autor:
Paloma Gómez-Fernández, Aitzkoa Lopez de Lapuente Portilla, Ianire Astobiza, Jorge Mena, Andoni Urtasun, Vivian Altmann, Fuencisla Matesanz, David Otaegui, Elena Urcelay, Alfredo Antigüedad, Sunny Malhotra, Xavier Montalban, Tamara Castillo-Triviño, Laura Espino-Paisán, Orhan Aktas, Mathias Buttmann, Andrew Chan, Bertrand Fontaine, Pierre-Antoine Gourraud, Michael Hecker, Sabine Hoffjan, Christian Kubisch, Tania Kümpfel, Felix Luessi, Uwe K. Zettl, Frauke Zipp, Iraide Alloza, Manuel Comabella, Christina M. Lill, Koen Vandenbroeck
Publikováno v:
Cells, Vol 9, Iss 1, p 175 (2020)
The IL22RA2 locus is associated with risk for multiple sclerosis (MS) but causative variants are yet to be determined. In a single nucleotide polymorphism (SNP) screen of this locus in a Basque population, rs28385692, a rare coding variant substituti
Externí odkaz:
https://doaj.org/article/d1ddca86ae88401eaffb82945a610542
Autor:
Marta Fernández-Prieto, María Jesús Fernández-Aceñero, Natalia López-Palacios, Andrés Bodas, Sergio Farrais, David Cuevas, Virginia Pascual, M. Ángeles Cerón-Nieto, Saúl Horta-Herrera, Laura Espino-Paisán, Isabel Salazar, Concepción Núñez
Publikováno v:
Nutrients, Vol 11, Iss 11, p 2551 (2019)
Background: The CX3CL1−CX3CR1 axis has been related to numerous diseases. The aim of our study was to investigate its involvement in coeliac disease (CD) pathogenesis, particularly in the early phase of the disease. Methods: We collected peripheral
Externí odkaz:
https://doaj.org/article/942511664eb2411a9bf251eb8a3b960d