Výsledky vyhledávání - "Laura E. Wise"

Discriminative stimulus properties of 1.25 mg/kg clozapine in rats: Mediation by serotonin 5-HT 2 and dopamine D 4 receptors

Autor: Joseph H. Porter, Laura E. Wise, Benny Bang-Andersen, Adam J. Prus, Alan L. Pehrson, Scott D. Philibin, Jørn Arnt

Publikováno v: Brain Research. 1648:298-305

The atypical antipsychotic drug clozapine remains one of most effective treatments for schizophrenia, given a lack of extrapyramidal side effects, improvements in negative symptoms, cognitive impairment, and in symptoms in treatment-resistant schizop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d1cbc19706c393884785bd987d0139c
https://doi.org/10.1016/j.brainres.2016.08.004

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Early adolescent nicotine exposure affects later-life cocaine reward in mice

Autor: F. Ivy Carroll, Laura E. Wise, Mai Alajaji, Dana E. Selley, M. Imad Damaj, Matthew F. Lazenka, Rabha M. Younis, Amir Levine, Dena Kota, Laura J. Sim-Selley

Publikováno v: Neuropharmacology. 105:308-317

Adolescence represents a unique developmental period associated with increased risk-taking behavior and experimentation with drugs of abuse, in particular nicotine. We hypothesized that exposure to nicotine during early adolescence might increase the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5e89270a94e6869f5df63f4f97939d
https://doi.org/10.1016/j.neuropharm.2016.01.032

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Pharmacological characterization of repeated administration of the first generation abused synthetic cannabinoid CP47,497

Autor: Travis W. Grim, Kimberly L. Samano, Laura E. Wise, Dana E. Selley, Aron H. Lichtman, Laura J. Sim-Selly, Qing Tao, Alphonse Poklis, Bogna M. Ignatowska-Jankowska

Publikováno v: Journal of Basic and Clinical Physiology and Pharmacology. 27:217-228

A series of in vivo and in vitro assays were conducted to characterize the pharmacological effects of the first generation abused synthetic cannabinoid CP47,497, a racemic bicyclic cannabinoid that is similar in structure to the potent, high-efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0205d7bc4b18ebcd7ba2c00ae8ba0421
https://doi.org/10.1515/jbcpp-2015-0118

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Diacylglycerol lipase β inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain

Autor: Jenny L. Wilkerson, Sudeshna Ghosh, Benjamin F. Cravatt, Steven G. Kinsey, Deniz Bagdas, Molly S. Crowe, Aron H. Lichtman, B L Mason, Ku-Lung Hsu, Laura E. Wise, M. I. Damaj

Publikováno v: British Journal of Pharmacology. 173:1678-1692

Background and Purpose Inhibition of diacylglycerol lipase (DGL)β prevents LPS-induced pro-inflammatory responses in mouse peritoneal macrophages. Thus, the present study tested whether DGLβ inhibition reverses allodynic responses of mice in the LP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc68b4ce17a6e9fff7761a6f2695667c
https://doi.org/10.1111/bph.13469

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The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model

Autor: Benjamin F. Cravatt, Justin L. Poklis, William L Dewey, Travis W. Grim, Laura E. Wise, Aron H. Lichtman, Mohammed A. Mustafa, Micah J. Niphakis, Rehab A. Abdullah, Matthew L. Banks, Hamid I. Akbarali, Jenny L. Wilkerson

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 357:145-156

Serious clinical liabilities associated with the prescription of opiates for pain control include constipation, respiratory depression, pruritus, tolerance, abuse, and addiction. A recognized strategy to circumvent these side effects is to combine op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e09c629d832353200399ba14b1c813f
https://doi.org/10.1124/jpet.115.229971

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Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice

Autor: Qing-song Liu, Laura E. Wise, Lenka Hruba, Travis W. Grim, Christina R. Merritt, Aron H. Lichtman, Dana E. Selley, Laura J. Sim-Selley, Steven G. Kinsey, Rehab A. Abdullah, Lance R. McMahon, Sudeshna Ghosh, Benjamin F. Cravatt

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 354:111-120

Inhibition of fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL), the primary hydrolytic enzymes for the respective endocannabinoids N-arachidonoylethanolamine (AEA) and 2-arachidonylglycerol (2-AG), produces antinociception but with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fcb91ddef576a24afce2a41ea92d4b4
https://doi.org/10.1124/jpet.115.222851

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Synaptic Dysfunction in the Hippocampus Accompanies Learning and Memory Deficits in Human Immunodeficiency Virus Type-1 Tat Transgenic Mice

Autor: Laura E. Wise, Kurt F. Hauser, Bogna M. Ignatowska-Jankowska, Alexandre E. Medina, Michael A. Fox, Aron H. Lichtman, Thomas E. Krahe, Cecilia Bull, Jianmin Su, Pamela E. Knapp, William Guido, Sylvia Fitting, Robert P. Skoff

Publikováno v: Biological Psychiatry. 73:443-453

Background Human immunodeficiency virus (HIV) associated neurocognitive disorders (HAND), including memory dysfunction, continue to be a major clinical manifestation of HIV type-1 infection. Viral proteins released by infected glia are thought to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb9a2cd331d44eb82933d1ddd0d5bfee
https://doi.org/10.1016/j.biopsych.2012.09.026

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Repeated Low-Dose Administration of the Monoacylglycerol Lipase Inhibitor JZL184 Retains Cannabinoid Receptor Type 1–Mediated Antinociceptive and Gastroprotective Effects

Autor: Rehab A. Abdullah, Benjamin F. Cravatt, Steven G. Kinsey, Laura E. Wise, Dana E. Selley, Divya Ramesh, Aron H. Lichtman

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 345:492-501

The monoacylglycerol lipase (MAGL) inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) produces antinociceptive and anti-inflammatory effects. However, repeated administration of high-dose JZL184 (40

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad0f3fa2d43942fed8883ae0d97e782
https://doi.org/10.1124/jpet.112.201426

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Inhalation exposure to smoke from synthetic 'marijuana' produces potent cannabimimetic effects in mice

Autor: Jason M. Wiebelhaus, Aron H. Lichtman, Laura E. Wise, Robert E. Vann, Alphonse Poklis, Justin L. Poklis

Publikováno v: Drug and Alcohol Dependence. 126:316-323

Background Use of synthetic “marijuana” has increased in recent years, produced adverse effects and prompted the temporary DEA ban of five specific cannabinoid analogs, including JWH-018. The objectives of the current study include determining th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d1f584eab5c5f03a169c5980b5d653
https://doi.org/10.1016/j.drugalcdep.2012.05.034

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Detection and disposition of JWH-018 and JWH-073 in mice after exposure to 'Magic Gold' smoke

Autor: Jason M. Wiebelhaus, Alphonse Poklis, Laura E. Wise, Dorra Amira, Brenda J. Haggerty, Justin L. Poklis

Publikováno v: Forensic Science International. 220:91-96

The disposition in mice of the cannabimimetics JWH-018 and JWH-073 in blood and brain following inhalation of the smoke from the herbal incense product (HIP) “Magic Gold” containing 3.6% JWH-018, 5.7% JWH-073 and less than 0.1% JWH-398 (w/w) is p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa79b49d5ed48e40f8160359325b191a
https://doi.org/10.1016/j.forsciint.2012.02.003

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