Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laura E. Wester"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Aging is associated with declining protein homeostasis. Here, using a chemical mutagenesis screen for lifespan extension in C. elegans, the authors report that inhibition of the integrated stress response enhances longevity and protein homeostasis in
Externí odkaz:
https://doaj.org/article/9a0b16e7b2bc4663b337481e2bbfff36
Autor:
Gabriel A Guerrero, Maxime J Derisbourg, Felix AMC Mayr, Laura E Wester, Marco Giorda, J Eike Dinort, Matías D Hartman, Klara Schilling, María José Alonso-De Gennaro, Ryan J Lu, Bérénice A Benayoun, Martin S Denzel
Publikováno v:
eLife, Vol 10 (2021)
Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective Caenorhabditis elegans mutants that are long-lived and stress resistant. We find that mu
Externí odkaz:
https://doaj.org/article/b5da5aa2ccee4aeda56385feab2e8031
Autor:
Laura E. Wester, Anne Lanjuin, Emanuel H.W. Bruckisch, Maria C. Perez-Matos, Peter G. Stine, Caroline Heintz, Martin S. Denzel, William B. Mair
Publikováno v:
Cell Rep Methods
Here, we introduce a single-copy knockin translating ribosome immunoprecipitation (SKI TRIP) toolkit, a collection of Caenorhabditis elegans strains engineered by CRISPR in which tissue-specific expression of FLAG-tagged ribosomal subunit protein RPL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64a426d2278e05a3c826cc19af3f87d
https://europepmc.org/articles/PMC10088236/
https://europepmc.org/articles/PMC10088236/
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nat Commun
Nature Communications
Nat Commun
Protein homeostasis is modulated by stress response pathways and its deficiency is a hallmark of aging. The integrated stress response (ISR) is a conserved stress-signaling pathway that tunes mRNA translation via phosphorylation of the translation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e32dd84b9fa3df896e47dd5bcd22d4
https://doaj.org/article/9a0b16e7b2bc4663b337481e2bbfff36
https://doaj.org/article/9a0b16e7b2bc4663b337481e2bbfff36
Autor:
Laura E. Wester, Anne Lanjuin, Emanuel H. W. Bruckisch, Maria C. Perez Matos, Caroline Heintz, Martin S. Denzel, William B. Mair
Translating Ribosome Affinity Purification (TRAP) methods have emerged as a powerful approach to profile actively translated transcripts in specific cell and tissue types. Epitope tagged ribosomal subunits are expressed in defined cell populations an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c989cbf9c30fae1d5b33e92257d4549
https://doi.org/10.1101/2021.12.22.473890
https://doi.org/10.1101/2021.12.22.473890
Autor:
María José Alonso-De Gennaro, Martin S. Denzel, Laura E Wester, Bérénice A. Benayoun, Ryan J Lu, Marco Giorda, Felix A.M.C. Mayr, Maxime J. Derisbourg, Gabriel A Guerrero, Klara Schilling, Matías D. Hartman, J Eike Dinort
Publikováno v:
eLife, Vol 10 (2021)
Elife
Elife
Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective Caenorhabditis elegans mutants that are long-lived and stress resistant. We find that mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212c5232c28952f7dc5545761466ccba
https://doi.org/10.7554/elife.53174
https://doi.org/10.7554/elife.53174
Autor:
Gabriel A Guerrero, Martin S. Denzel, Felix A.M.C. Mayr, J Eike Dinort, Klara Schilling, Ryan J Lu, Bérénice A. Benayoun, María José Alonso-De Gennaro, Maxime J. Derisbourg, Laura E Wester, Marco Giorda, Matías D. Hartman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::836e12016dd44f5d86c68ca117fd7767
https://doi.org/10.7554/elife.53174.sa2
https://doi.org/10.7554/elife.53174.sa2
Protein homeostasis is modulated by stress response pathways and its deficiency is a hallmark of aging. The integrated stress response (ISR) is a conserved stress-signaling pathway that tunes mRNA translation via phosphorylation of the translation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::722789439bd237ec757127cfa9c912b8
https://doi.org/10.1101/2020.08.13.244970
https://doi.org/10.1101/2020.08.13.244970
Autor:
J Eike Dinort, Gabriel A Guerrero, María J. Alonso, Felix A.M.C. Mayr, Matías D. Hartman, Klara Schilling, Laura E Wester, Martin S. Denzel, Bérénice A. Benayoun, Marco Gordia, Maxime J. Derisbourg, Ryan J Lu
Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory defective Caenorhabditis elegans mutants that are long-lived and stress resistant. We find that mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a912ff6d1531045935c3b32e48148201
Autor:
Gabriel A, Guerrero, Maxime J, Derisbourg, Felix Amc, Mayr, Laura E, Wester, Marco, Giorda, J Eike, Dinort, Matías D, Hartman, Klara, Schilling, María José, Alonso-De Gennaro, Ryan J, Lu, Bérénice A, Benayoun, Martin S, Denzel
Publikováno v:
eLife. 10
Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::197c1559ae7676976943d88d1b67f6da
https://pubmed.ncbi.nlm.nih.gov/34448454
https://pubmed.ncbi.nlm.nih.gov/34448454