Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Laura E. Welsh"'
Macrophage Migration Inhibitory Factor Governs Endothelial Cell Sensitivity to LPS-Induced Apoptosis
Autor:
David B. Pearse, Alan Chesley, Bedri Karakas, Julie Nijmeh, Rachel L. Damico, Laura E. Welsh, Joe G.N. Garcia, Eric Amaro, Eric P. Bind, Michael T. Crow, Laura Johnston
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 39:77-85
Human endothelial cells (EC) are typically resistant to the apoptotic effects of stimuli associated with lung disease. The determinants of this resistance remain incompletely understood. Macrophage migration inhibitory factor (MIF) is a proinflammato
Autor:
Laura E. Welsh-Servinsky, Jeffrey M. Dodd-o, Maria L. Hristopoulos, David B. Pearse, Clarke G. Tankersley
Publikováno v:
Journal of Applied Physiology. 100:1590-1595
Ischemia-reperfusion (I/R) lung injury is characterized by increased pulmonary endothelial permeability and edema, but the genetic basis for this injury is unknown. We utilized an in vivo mouse preparation of unilateral lung I/R to evaluate the genet
Autor:
David B. Pearse, Alexander D. Verin, Larissa A. Shimoda, R. Scott Stephens, Laura E. Welsh-Servinsky, Aigul Moldobaeva, Rubin M. Tuder
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L919-L930
Increases in endothelial cGMP prevent oxidant-mediated endothelial barrier dysfunction, but the downstream mechanisms remain unclear. To determine the role of cGMP-dependent protein kinase (PKG)I, human pulmonary artery endothelial cells (HPAEC) lack
Autor:
David B. Pearse, Jay G. Shake, David J. Caparrelli, Peter L. Walinsky, Jay L. Zweier, Eric A. Peck, Laura E. Welsh, William A. Baumgartner, Jorge D. Salazar, Jeffrey M. Dodd-o, Roy C. Ziegelstein
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H927-H936
Cardiopulmonary bypass (CPB) causes acute lung injury. Reactive oxygen species (ROS) from NADPH oxidase may contribute to this injury. To determine the role of NADPH oxidase, we pretreated pigs with structurally dissimilar NADPH oxidase inhibitors. L
Publikováno v:
Journal of Clinical Microbiology. 35:3078-3081
The cellular quality of the endocervical swab specimen used for the detection of Chlamydia trachomatis may dramatically impact the sensitivity of the diagnostic assay used. An evaluation of the adequacy of 319 endocervical swab specimens from women a
Autor:
Laura E. Welsh, Edward W. Hook, Raphael P. Viscidi, Thomas C. Quinn, Charlotte A. Gaydos, Linda Bobo
Publikováno v:
Sexually Transmitted Diseases. 19:303-308
A portion of the major outer membrane protein (MOMP) gene from 15 Chlamydia trachomatis serovars was amplified by polymerase chain reaction (PCR) and the product was analyzed by restriction fragment length polymorphism (RFLP). A set of primers was us
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:291-294
The in vitro activities of azithromycin (CP-62,993; Pfizer), erythromycin, and tetracycline were evaluated by inhibiting Chlamydia trachomatis and Chlamydia pneumoniae, formerly TWAR, propagation in vitro in McCoy cells, HeLa cells, and HL cells. Ele
Autor:
Alfredo Gonzalez, David B. Pearse, Kathleen K. Kibler, Maria L. Hristopoulos, Jolanta Gutkowska, Jeffrey M. Dodd-o, Suhayla Mukaddam-Daher, Laura E. Welsh-Servinsky
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 294(4)
Ischemia-reperfusion (IR) causes human lung injury in association with the release of atrial and brain natriuretic peptides (ANP and BNP), but the role of ANP/BNP in IR lung injury is unknown. ANP and BNP bind to natriuretic peptide receptor-A (NPR-A
Autor:
Gabriele V. Ronnett, Larissa A. Shimoda, Laura E. Welsh, David B. Pearse, Cheil Moon, Patrice M. Becker, Alexander D. Verin, Natalia V. Bogatcheva
Publikováno v:
Endothelium : journal of endothelial cell research. 10(6)
The authors determined the effect of cyclic guanosine 3',5'-monophosphate (cGMP) on hydrogen peroxide (H(2)O(2))-induced barrier dysfunction in bovine lung microvascular endothelial cell (BLMVEC) monolayers and compared the results to bovine pulmonar
Autor:
Stephen M. Cattaneo, Brian T. Bethea, William A. Baumgartner, Laura E. Welsh, Eric A. Peck, Jorge D. Salazar, David B. Pearse, Jay G. Shake, Jeffrey M. Dodd-o, David J. Caparrelli, Peter L. Walinsky
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 286(2)
Cardiovascular surgery requiring cardiopulmonary bypass (CPB) is frequently complicated by postoperative lung injury. Bronchial artery (BA) blood flow has been hypothesized to attenuate this injury. The purpose of the present study was to determine t