Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Laura E. Mccoy"'
Autor:
Natalie M. Edner, Luke P. Houghton, Elisavet Ntavli, Chloe Rees-Spear, Lina Petersone, Chunjing Wang, Astrid Fabri, Yassin Elfaki, Andrea Rueda Gonzalez, Rachel Brown, Kai Kisand, Pärt Peterson, Laura E. McCoy, Lucy S. K. Walker
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Circulating follicular helper T cells (cTfh) can show phenotypic alterations in disease settings, including in the context of tissue-damaging autoimmune or anti-viral responses. Using severe COVID-19 as a paradigm of immune dysregulation, we have exp
Externí odkaz:
https://doaj.org/article/e691596e5a1945598aa5b7e47fe61d36
Autor:
Peter Thomas, Chloe Rees-Spear, Sarah Griffith, Luke Muir, Emma Touizer, Raiees Andrabi, Richard Priest, Jennifer Percival-Alwyn, Darryl Hayward, Amanda Buxton, William Traylen, Benny Chain, Trevor Wattam, Irene Sanjuan Nandin, Laura E. McCoy
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109495- (2024)
Summary: Antigen-specific antibody infusion is known to enhance or suppress germinal center (GC) responses depending on the affinity of the infusion. We hypothesized that infusing monoclonal antibodies (mAbs) of escalating affinity during an immuniza
Externí odkaz:
https://doaj.org/article/0b1bcca32ac54979a20f34a6710b4940
Autor:
Aljawharah Alrubayyi, Emma Touizer, Dan Hameiri-Bowen, Bethany Charlton, Ester Gea-Mallorquí, Noshin Hussain, Kelly A. S. da Costa, Rosemarie Ford, Chloe Rees-Spear, Thomas A. Fox, Ian Williams, Laura Waters, Tristan J. Barber, Fiona Burns, Sabine Kinloch, Emma Morris, Sarah Rowland-Jones, Laura E. McCoy, Dimitra Peppa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Natural killer (NK) cell subsets with adaptive properties are emerging as regulators of vaccine-induced T and B cell responses and are specialized towards antibody-dependent functions contributing to SARS-CoV-2 control. Although HIV-1 infect
Externí odkaz:
https://doaj.org/article/70138abd614b49439a1b4d0f54bbd764
Autor:
Isabella A.T.M. Ferreira, Colin Y.C. Lee, William S. Foster, Adam Abdullahi, Lisa M. Dratva, Zewen Kelvin Tuong, Benjamin J. Stewart, John R. Ferdinand, Stephane M. Guillaume, Martin O.P. Potts, Marianne Perera, Benjamin A. Krishna, Ana Peñalver, Mia Cabantous, Steven A. Kemp, Lourdes Ceron-Gutierrez, Soraya Ebrahimi, Paul Lyons, Kenneth G.C. Smith, John Bradley, Dami A. Collier, Laura E. McCoy, Agatha van der Klaauw, James E.D. Thaventhiran, I. Sadaf Farooqi, Sarah A. Teichmann, Paul A. MacAry, Rainer Doffinger, Mark R. Wills, Michelle A. Linterman, Menna R. Clatworthy, Ravindra K. Gupta
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112991- (2023)
Summary: Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on responses to booster third doses. Here, we show that individuals 70 years or older (median
Externí odkaz:
https://doaj.org/article/ae089416071a4557966b754f87892413
Autor:
Emma Touizer, Aljawharah Alrubayyi, Rosemarie Ford, Noshin Hussain, Pehuén Pereyra Gerber, Hiu-Long Shum, Chloe Rees-Spear, Luke Muir, Ester Gea-Mallorquí, Jakub Kopycinski, Dylan Jankovic, Anna Jeffery-Smith, Christopher L. Pinder, Thomas A. Fox, Ian Williams, Claire Mullender, Irfaan Maan, Laura Waters, Margaret Johnson, Sara Madge, Michael Youle, Tristan J. Barber, Fiona Burns, Sabine Kinloch, Sarah Rowland-Jones, Richard Gilson, Nicholas J. Matheson, Emma Morris, Dimitra Peppa, Laura E. McCoy
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105862- (2023)
Summary: We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb)
Externí odkaz:
https://doaj.org/article/95e40d2350b047459324835a55cd7d61
Autor:
Aljawharah Alrubayyi, Ester Gea-Mallorquí, Emma Touizer, Dan Hameiri-Bowen, Jakub Kopycinski, Bethany Charlton, Natasha Fisher-Pearson, Luke Muir, Annachiara Rosa, Chloe Roustan, Christopher Earl, Peter Cherepanov, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Tao Dong, Lucy Dorrell, Sarah Rowland-Jones, Laura E. McCoy, Dimitra Peppa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Understanding the pathology and immunological response to SARS CoV2 infection in specific patient groups is essential for informing the scientific and clinical handling of infections within these patient populations. Here the authors characterise the
Externí odkaz:
https://doaj.org/article/de4813a9861e43bab28f9f0beeed1ff5
Autor:
Anna Jeffery-Smith, Alice R. Burton, Sabela Lens, Chloe Rees-Spear, Jessica Davies, Monika Patel, Robin Gopal, Luke Muir, Felicity Aiano, Katie J. Doores, J. Yimmy Chow, Shamez N. Ladhani, Maria Zambon, Laura E. McCoy, Mala K. Maini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Memory B cells (MBCs) can provide a recall response able to supplement waning antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses. We studied a cohort of elderly care home residents and younger staff (median a
Externí odkaz:
https://doaj.org/article/4e603982f9904faf8768698a2faaf045
Autor:
Sarah A. Griffith, Laura E. McCoy
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Since their discovery, antibodies capable of broad neutralisation have been at the forefront of HIV-1 research and are of particular interest due to in vivo passive transfer studies demonstrating their potential to provide protection. Currently an ex
Externí odkaz:
https://doaj.org/article/60c9aaec86d54603a73e859f8d68c3a3
Autor:
Nishkantha Arulkumaran, PhD, Timothy Arthur Chandos Snow, FFICM, Adarsh Kulkarni, MD, David Brealey, PhD, Hannah Rickman, MB BChir, Chloe Rees-Spear, MSc, Moira J. Spyer, PhD, Judith Heaney, PhD, Edmund Garr, PhD, Bryan Williams, PhD, Peter Cherepanov, PhD, George Kassiotis, PhD, Michael Lunn, PhD, Catherine Houlihan, PhD, Laura E. McCoy, PhD, Eleni Nastouli, FRCPath, Mervyn Singer, FRCP
Publikováno v:
Critical Care Explorations, Vol 3, Iss 8, p e0488 (2021)
OBJECTIVES:. Multiple mechanisms have been proposed to explain disease severity in coronavirus disease 2019. Therapeutic approaches need to be underpinned by sound biological rationale. We evaluated whether serum levels of a range of proposed coronav
Externí odkaz:
https://doaj.org/article/46925e63079a4baeb0e11e661970cd1c
Autor:
Chloe Rees-Spear, Luke Muir, Sarah A. Griffith, Judith Heaney, Yoann Aldon, Jonne L. Snitselaar, Peter Thomas, Carl Graham, Jeffrey Seow, Nayung Lee, Annachiara Rosa, Chloe Roustan, Catherine F. Houlihan, Rogier W. Sanders, Ravindra K. Gupta, Peter Cherepanov, Hans J. Stauss, Eleni Nastouli, Katie J. Doores, Marit J. van Gils, Laura E. McCoy
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108890- (2021)
Summary: Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the viral entry protein, spike. Because new SARS-CoV-2 variants are
Externí odkaz:
https://doaj.org/article/78e75387f25c4488ad981560e9ef8e93