Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Laura E. McVeigh"'
Autor:
Nicola Ingram, Laura E. McVeigh, Radwa H. Abou-Saleh, Damien V. B. Batchelor, Paul M. Loadman, James R. McLaughlan, Alexander F. Markham, Stephen D. Evans, P. Louise Coletta
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 622 (2022)
Advanced drug delivery systems, such as ultrasound-mediated drug delivery, show great promise for increasing the therapeutic index. Improvements in delivery by altering the ultrasound parameters have been studied heavily in vitro but relatively littl
Externí odkaz:
https://doaj.org/article/102e52c5286745469f1868078ad550f9
Autor:
Milene Volpato, Laura E. McVeigh, Paul M. Loadman, Nicola Ingram, Victoria Mico, P. Louise Coletta, Sally A. Peyman, Antonia Charalambous, Gemma Marston, Richard J. Bushby, Alexander F. Markham, Antonia Wierzbicki, James R. McLaughlan, Stephen D. Evans
Publikováno v:
Charalambous, A, Mico, V, McVeigh, L E, Marston, G, Ingram, N, Volpato, M, Peyman, S A, McLaughlan, J R, Wierzbicki, A, Loadman, P, Bushby, R J, Markham, A F, Evans, S D & Coletta, P L 2021, ' Targeted microbubbles carrying lipid-oil-nanodroplets for ultrasound-triggered delivery of the hydrophobic drug, Combretastatin A4 ', Nanomedicine: Nanotechnology, Biology and Medicine . https://doi.org/10.1016/j.nano.2021.102401
The hydrophobicity of a drug can be a major challenge in its development and prevents the clinical translation of highly potent anti-cancer agents. We have used a lipid-based nanoemulsion termed Lipid-Oil-Nanodroplets (LONDs) for the encapsulation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956aa26c1f728025c4e633fec19af743
https://eprints.whiterose.ac.uk/177393/6/1-s2.0-S1549963421000447-main.pdf
https://eprints.whiterose.ac.uk/177393/6/1-s2.0-S1549963421000447-main.pdf
Autor:
R. Prasad, Laura E. McVeigh, Imeshi Wijetunga, Gemma Marston, Nicola Ingram, PL Coletta, Alex F. Markham
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific reports
Scientific Reports
McVeigh, L E, Wijetunga, I, Ingram, N, Marston, G, Prasad, R, Markham, A F & Coletta, P L 2019, ' Development of orthotopic tumour models using ultrasound-guided intrahepatic injection ', Scientific Reports, vol. 9, no. 1, 9904 . https://doi.org/10.1038/s41598-019-46410-6
Scientific reports
Scientific Reports
McVeigh, L E, Wijetunga, I, Ingram, N, Marston, G, Prasad, R, Markham, A F & Coletta, P L 2019, ' Development of orthotopic tumour models using ultrasound-guided intrahepatic injection ', Scientific Reports, vol. 9, no. 1, 9904 . https://doi.org/10.1038/s41598-019-46410-6
Mouse models of human diseases are an essential part of the translational pipeline. Orthotopic tumour mouse models are increasingly being used in cancer research due to their increased clinical relevance over subcutaneous xenograft models, particular
Autor:
Sally A. Peyman, Malcolm Haddrick, William Townley, Michael Fairclough, Elizabeth M. A. Valleley, Nicola Ingram, Antonia Wierzbicki, Richard J. Bushby, Radwa H. Abou-Saleh, Stephen D. Evans, Pamela F. Jones, Gemma Marston, Darren Treanor, Milene Volpato, Antonia Charalambous, Juliana Maynard, Neil H. Thomson, Laura E. McVeigh, J. Anthony Evans, Jorge L Jimenez-Macias, A Wright, P. Louise Coletta, Peter B Simpson, Benjamin R. G. Johnson, Steven Freear, Alexander F. Markham, James R. McLaughlan, Paul M. Loadman
Publikováno v:
Fairclough, M 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumour drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 4 . https://doi.org/10.7150/thno.49670
Ingram, N, McVeigh, L E, Abou-Saleh, R H, Maynard, J, Peyman, S A, McLaughlan, J R, Fairclough, M, Marston, G, Valleley, E M A, Jimenez-Macias, J L, Charalambous, A, Townley, W, Haddrick, M, Wierzbicki, A, Wright, A, Volpato, M, Simpson, P B, Treanor, D E, Thomson, N H, Loadman, P M, Bushby, R J, Johnson, B R G, Jones, P F, Evans, J A, Freear, S, Markham, A F, Evans, S D & Coletta, P L 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 24, pp. 10973-10992 . https://doi.org/10.7150/thno.49670
Theranostics
Ingram, N, McVeigh, L E, Abou-Saleh, R H, Maynard, J, Peyman, S A, McLaughlan, J R, Fairclough, M, Marston, G, Valleley, E M A, Jimenez-Macias, J L, Charalambous, A, Townley, W, Haddrick, M, Wierzbicki, A, Wright, A, Volpato, M, Simpson, P B, Treanor, D E, Thomson, N H, Loadman, P M, Bushby, R J, Johnson, B R G, Jones, P F, Evans, J A, Freear, S, Markham, A F, Evans, S D & Coletta, P L 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 24, pp. 10973-10992 . https://doi.org/10.7150/thno.49670
Theranostics
Most cancer patients receive chemotherapy at some stage of their treatment which makes improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large numbers of potent anti-cancer agents being developed, a major obstacle to cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8743562efc9f20857e1d1305e425ca8f
https://www.research.manchester.ac.uk/portal/en/publications/ultrasoundtriggered-therapeutic-microbubbles-enhance-the-efficacy-of-cytotoxic-drugs-by-increasing-circulation-and-tumour-drug-accumulation-and-limiting-bioavailability-and-toxicity-in-normal-tissues(d99d292e-9ff7-4039-a343-5bfeafca0d06).html
https://www.research.manchester.ac.uk/portal/en/publications/ultrasoundtriggered-therapeutic-microbubbles-enhance-the-efficacy-of-cytotoxic-drugs-by-increasing-circulation-and-tumour-drug-accumulation-and-limiting-bioavailability-and-toxicity-in-normal-tissues(d99d292e-9ff7-4039-a343-5bfeafca0d06).html
Autor:
Antonia Charalambous, K. Raj Prasad, Imeshi Wijetunga, Nicola Ingram, Ian M. Carr, Laura E. McVeigh, Amit Nair, Agne Antanaviciute, P. Louise Coletta
Publikováno v:
Cancers, Vol 12, Iss 2817, p 2817 (2020)
Wijetunga, I, Mcveigh, L E, Charalambous, A, Antanaviciute, A, Carr, I M, Nair, A, Prasad, K R, Ingram, N & Coletta, P L 2020, ' Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review ', Cancers, vol. 12, no. 10, pp. 2817 . https://doi.org/10.3390/cancers12102817
Cancers
Wijetunga, I, Mcveigh, L E, Charalambous, A, Antanaviciute, A, Carr, I M, Nair, A, Prasad, K R, Ingram, N & Coletta, P L 2020, ' Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review ', Cancers, vol. 12, no. 10, pp. 2817 . https://doi.org/10.3390/cancers12102817
Cancers
Simple Summary Bile duct cancers are rare cancers that have poor prospects and limited treatment options. Recently, significant advances have been made in the field of nanomedicine which has allowed new approaches to the diagnosis and treatment (i.e.
Autor:
Anne L. Thomas, Laura E. McVeigh, Karen Brown, Lynne M. Howells, Stewart Sale, Jagdish Mahale, William P. Steward
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 350:483-494
Lung cancer is responsible for over one million deaths worldwide each year. Smoking cessation for lung cancer prevention remains key, but it is increasingly acknowledged that prevention strategies also need to focus on high-risk groups, including ex-
Publikováno v:
Molecular nutritionfood research. 59(3)
cope Hepatocellular carcinoma is one of the most frequently occurring cancers in humans. Recent human and animal studies have provided strong evidence for the effects of dietary deficiency of methyl donors on the development of liver cancer. However,