Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Laura E. McCoubrey"'
Autor:
Farhan Taherali, Nerisha Chouhan, Fanjin Wang, Sebastien Lavielle, Maryana Baran, Laura E. McCoubrey, Abdul W. Basit, Vipul Yadav
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1956 (2023)
Most marketed peptide drugs are administered parenterally due to their inherent gastrointestinal (GI) instability and poor permeability across the GI epithelium. Several molecular design techniques, such as cyclisation and D-amino acid (D-AA) substit
Externí odkaz:
https://doaj.org/article/ba233770da3d491cb250517e1d06cea2
Autor:
Vipul Yadav, Aileen House, Silvia Matiz, Laura E. McCoubrey, Kimberly A. Bettano, Leena Bhave, Meiyao Wang, Peter Fan, Siqun Zhou, Janice D. Woodhouse, Eirini Poimenidou, Liu Dou, Abdul W. Basit, Lily Y. Moy, Robert Saklatvala, Laxminarayan G. Hegde, Hongshi Yu
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2385 (2022)
Janus kinase (JAK) inhibitors, such as tofacitinib (Xeljanz) and filgotinib (Jyseleca), have been approved for treatment of ulcerative colitis with several other JAK inhibitors in late-stage clinical trials for inflammatory bowel disease (IBD). Despi
Externí odkaz:
https://doaj.org/article/f846cb0cf29a4fa0a0c6b7c02c1e2aed
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
The last twenty years of seminal microbiome research has uncovered microbiota’s intrinsic relationship with human health. Studies elucidating the relationship between an unbalanced microbiome and disease are currently published daily. As such, micr
Externí odkaz:
https://doaj.org/article/593971a7956247a08d184a5fe71e8cdd
Autor:
Laura E. McCoubrey, Stavriani Thomaidou, Moe Elbadawi, Simon Gaisford, Mine Orlu, Abdul W. Basit
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2001 (2021)
Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher. Microbial drug depletion is often variable
Externí odkaz:
https://doaj.org/article/b0ee54b8f61c4f899cbb4335b060c7dd
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1026 (2021)
The human gut microbiome, composed of trillions of microorganisms, plays an essential role in human health. Many factors shape gut microbiome composition over the life span, including changes to diet, lifestyle, and medication use. Though not routine
Externí odkaz:
https://doaj.org/article/ebbae4df5a7c474880fcb5b038cac829
Autor:
Vipul Yadav, Yang Mai, Laura E. McCoubrey, Yasufumi Wada, Motoyasu Tomioka, Satofumi Kawata, Shrikant Charde, Abdul W. Basit
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 578 (2021)
5-Aminolevulinic acid (5-ALA) is a naturally occurring nonprotein amino acid licensed as an optical imaging agent for the treatment of gliomas. In recent years, 5-ALA has been shown to possess anti-inflammatory and immunoregulatory properties through
Externí odkaz:
https://doaj.org/article/72469aa73fcc48c1939653ef44a4a3ef
Autor:
Zoe Coombes, Vipul Yadav, Laura E. McCoubrey, Cristina Freire, Abdul W. Basit, R. Steven Conlan, Deyarina Gonzalez
Publikováno v:
Pharmaceutics, Vol 12, Iss 8, p 760 (2020)
Following oral administration, the bioavailability of progestogens is very low and highly variable, in part due to metabolism by cytochrome P450 enzymes found in the mucosa of the small intestine. Conversely, the mucosa in the colon contains much low
Externí odkaz:
https://doaj.org/article/446518e37d4f49ee8f9a7010a763dc99
Publikováno v:
Trends in Pharmacological Sciences. 43:281-292
The microbiome is experiencing increasing scrutiny for its role in disease, and the number of new research reports describing microbiome-disease relationships is growing exponentially. Researchers are increasingly working to translate the emerging fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b4ab0de79b05bb5924768730fbfc0e
https://doi.org/10.1016/j.tips.2022.02.001
https://doi.org/10.1016/j.tips.2022.02.001
Autor:
Yang Mai, Yaqi Ouyang, Yujia Qin, Changchang Jia, Laura E. McCoubrey, Abdul W. Basit, Yichu Nie, Yizhen Jia, Liu Yu, Liu Dou, Wenbin Deng, Yang Deng, Yang Liu
Publikováno v:
Nanoscale. 14:8418-8428
The effective treatment of esophageal disease represents a significant unmet clinical need, as existing treatments often lead to unnecessary systemic drug exposure and suboptimal concentrations at the disease site. Here, surface-modified bioadhesive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf48608aaf936b995d951da1d9b72fc
https://doi.org/10.1039/d2nr01846b
https://doi.org/10.1039/d2nr01846b
Publikováno v:
Biopharmaceutics. :277-295
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7b97983de317549792588af19348ca7
https://doi.org/10.1002/9781119678366.ch17
https://doi.org/10.1002/9781119678366.ch17