Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Laura E. Klein"'
Autor:
Garry A. Williams, Luis Cardoso, Oran D. Kennedy, Laura E. Klein, Martin L. Adamo, Zhenwei Gong, Ronald W. Matheny, Hui Sun, Mitchell B. Schaffler, Radhika Muzumdar, Shoshana Yakar, Gene B. Hubbard, Yuji Ikeno, Yingjie Wu, Roger P. Farrar
Publikováno v:
Aging Cell
In lower or simple species, such as worms and flies, disruption of the insulin-like growth factor (IGF)-1 and the insulin signaling pathways has been shown to increase lifespan. In rodents, however, growth hormone (GH) regulates IGF-1 levels in serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9386eb40ed33003811ccdd3fac08f9
http://europepmc.org/articles/PMC4326899
http://europepmc.org/articles/PMC4326899
Autor:
Susheel Gundewar, John W. Calvert, Saurabh Jha, Madhav Lavu, Sang Yong Ji, Yoni Weinberg, Anjana Nemkal, David J. Lefer, Derek M. Huffman, Benjamin L. Predmore, Radhika Muzumdar, Lingguang Cui, Laura E. Klein, Gil Atzmon
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 30:1940-1948
Objective— Humanin (HN), an endogenous antiapoptotic peptide, has previously been shown to protect against Alzheimer’s disease and a variety of cellular insults. We evaluated the effects of a potent analog of HN (HNG) in an in vivo murine model o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0e5b571ef0a27ed858b80e8dac30da
https://doi.org/10.1161/atvbaha.110.205997
https://doi.org/10.1161/atvbaha.110.205997
Publikováno v:
Cell Cycle. 4:501-507
Discodermolide is a microtubule stabilizing agent that suppresses dynamic instability and blocks cells in mitosis. Selection of A549 nonsmall cell lung carcinoma cells with increasing concentrations of discodermolide yielded a clone that proliferated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d367d3a3aee8a2b3336210343dd62570
https://doi.org/10.4161/cc.4.3.1550
https://doi.org/10.4161/cc.4.3.1550
Autor:
Laura E. Klein, Zhenwei Gong, Kai Su, Claire C. Bastie, Derek M. Huffman, Nir Barzilai, Norman Fleischer, Radhika Muzumdar, Lingguang Cui, Anjana Nemkal, Manju Surana, Regina Kuliawat, Marianna Nicoletta-Gentile
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(12)
Humanin (HN) is a 24-aa polypeptide that offers protection from Alzheimer's disease and myocardial infarction, increases insulin sensitivity, improves survival of β cells, and delays onset of diabetes. Here we examined the acute effects of HN on ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3d0954a9c3f9d7f4477302419e659b
https://pubmed.ncbi.nlm.nih.gov/23995290
https://pubmed.ncbi.nlm.nih.gov/23995290
A potent analog (HNG) of the endogenous peptide humanin protects against myocardial ischemia–reperfusion (MI–R) injury in vivo, decreasing infarct size and improving cardiac function. Since oxidative stress contributes to the damage from MI–R w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112a3300a9f46efb44797e106760db25
https://europepmc.org/articles/PMC3853355/
https://europepmc.org/articles/PMC3853355/
Publikováno v:
Journal of Molecular and Cellular Cardiology. 28:33-42
It is established that thyroxine-induced ventricular hypertrophy is associated with downregulation of collagen type I gene expression and increased collagen turnover in the ventricular tissue. The present study was undertaken to test the hypothesis t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b737ade7d911a935052ea09e70fb7f
https://doi.org/10.1006/jmcc.1996.0004
https://doi.org/10.1006/jmcc.1996.0004
Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents
Autor:
Laura E. Klein, Susan Band Horwitz
Publikováno v:
Cancer Drug Discovery and Development ISBN: 9781588295279
The antitumor drug Taxol is recognized for its efficacy in the treatment of cancer and has become the prototype for a class of drugs known as the microtubule-stabilizing agents (MSAs). Despite years of investigation, a clear and detailed mechanism by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b625d8d1c8e11020f94acf59177e4601
https://doi.org/10.1007/978-1-59745-221-2_23
https://doi.org/10.1007/978-1-59745-221-2_23
Publikováno v:
Journal of molecular and cellular cardiology. 30(11)
Thyroid hormone-induced ventricular hypertrophy is characterized by the absence of fibrosis. Previously, we demonstrated that thyroid hormone inhibits collagen type I gene expression in the myocardium and in cardiac fibroblasts. We also demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e527ebf197b4dd739b10e34cb32d5f73
https://pubmed.ncbi.nlm.nih.gov/9925384
https://pubmed.ncbi.nlm.nih.gov/9925384
Publikováno v:
Brain research. Molecular brain research. 21(3-4)
We have analyzed the expression pattern of Na,K-ATPase alpha and beta subunit isoforms within the rodent and primate central nervous system. Membrane fractions prepared from rat cerebral cortical type-1 astrocytes and rat cerebellar granule and hippo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0c62e370a68ef59c765a02c1d02efc
https://pubmed.ncbi.nlm.nih.gov/8170354
https://pubmed.ncbi.nlm.nih.gov/8170354
Publikováno v:
Cell Biology International Reports. 12:1027-1036
The effect of triiodothyronine (T3) on the resting membrane potential was measured in primary cultured rat submandibular gland cells. The resting membrane potential was 29.5 +/- 0.71 mV. The hormone T3, at concentrations of 10(-9) M or greater, hyper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4c83b43d0b9cf395d85468c845f05d
https://doi.org/10.1016/0309-1651(88)90027-6
https://doi.org/10.1016/0309-1651(88)90027-6