Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laura E. Bowie"'
Autor:
Claudia L.K. Hung, Laura E Bowie, Carly R. Desmond, Tamara Maiuri, Ray Truant, Jianrun Xia, Susie Son
Publikováno v:
Journal of Biological Chemistry. 294:1915-1923
Huntington's disease (HD) is a neurodegenerative, age-onset disorder caused by a CAG DNA expansion in exon 1 of the HTT gene, resulting in a polyglutamine expansion in the huntingtin protein. Nuclear accumulation of mutant huntingtin is a hallmark of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a7430ce99693c2bfddaa6394203ab6
https://doi.org/10.1074/jbc.ra117.001440
https://doi.org/10.1074/jbc.ra117.001440
Autor:
Virginia B. Mattis, Claudia L.K. Hung, James Victor Giordano, Mina Falcone, Jonathan D. Schertzer, Tammy Gillis, Vanessa C. Wheeler, Ray Truant, Tamara Maiuri, Ryan Gotesman, Laura E Bowie, Karun K. Singh, Vickie Kwan, Susie Son, Trevor C. Lau
Publikováno v:
Molecular Biology of the Cell
The huntingtin protein participates in several cellular processes that are disrupted when the polyglutamine tract is expanded beyond a threshold of 37 CAG DNA repeats in Huntington’s disease (HD). Cellular biology approaches to understand these fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76c12fcccd5c60b1ea835d5ab51fb69
https://doi.org/10.1091/mbc.e18-09-0590
https://doi.org/10.1091/mbc.e18-09-0590
Publikováno v:
DNA and cell biology. 38(1)
A new hypothesis for the mechanism of Huntington's disease (HD) is driven by a small molecule lead that may connect age-associated reactive oxygen stress, oxidative DNA damage, and mitochondrial dysfunction. These pathways have also recently been def
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70952a7ffbac2c685d4877e690e5e14a
https://pubmed.ncbi.nlm.nih.gov/30481056
https://pubmed.ncbi.nlm.nih.gov/30481056
Autor:
Claudia L.K. Hung, Nicolas Arbez, Ray Truant, Jianrun Xia, David W. Litchfield, Nicholas T. Hertz, Shreya Patel, Danny Galleguillos, Christopher A. Ross, Tamara Maiuri, Laura E Bowie, Michelle Gabriel, Melanie Alpaugh, Simonetta Sipione
Publikováno v:
Biochemistry Publications
© 2018 National Academy of Sciences. All Rights Reserved. The huntingtin N17 domain is a modulator of mutant huntingtin toxicity and is hypophosphorylated in Huntington’s disease (HD). We conducted high-content analysis to find compounds that coul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03957d6f9326893cda9bde2a41db8646
https://pubmed.ncbi.nlm.nih.gov/29987005
https://pubmed.ncbi.nlm.nih.gov/29987005
Autor:
Laura E Bowie, Ryan Gotesman, Vanessa C. Wheeler, Claudia L.K. Hung, Ray Truant, Tamara Maiuri, Karun K. Singh, James Victor Giordano, Trevor C. Lau, Virginia B. Mattis, Mina Falcone, Jonathan D. Schertzer, Susie Son, Vickie Kwan
The huntingtin protein participates in several cellular processes that are disrupted when the polyglutamine tract is expanded beyond a threshold of 37 CAG DNA repeats in Huntington’s disease (HD). Cellular biology approaches to understand these fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7b94aa1763d7e8f202d215c64201b0
https://doi.org/10.1101/291575
https://doi.org/10.1101/291575
Publikováno v:
Canadian journal of physiology and pharmacology. 90(7)
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, in which the release of reactive oxygen species by infiltrating immune cells contributes to demyelination. American ginseng ( Panax quinquefolius ) is a natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36c747d8873b4114f744743d090cb7d
https://pubmed.ncbi.nlm.nih.gov/22720838
https://pubmed.ncbi.nlm.nih.gov/22720838